Frequency of Hepatopulmonary Syndrome (HPS) Among Patients With Liver Cirrhosis: A Letter to Editor

Mokhtarifar, Ali; Azimi, Hamidreza; Esmaeelzadeh, Abbas; Ebrahimi, Mehdi; Eghbali, Seyed Ahmad

doi:10.5812/hepatmon.35990

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…The most frequent liver pathology that leads to HPS is liver cirrhosis; nevertheless, the course and manifestation of the syndrome does not depend on the root cause of the liver damage. The development of HPS has been described in the course of the Budd-Chiari syndrome, in portal hypertension without any chronic liver disease, as well as in liver diseases without concomitant cirrhosis and portal hypertension [5,6]. The syndrome is defined as the concurrence of a triad of symptom: liver damage which may be concomitant with portal hypertension, hypoxemia resulting from the disorders in the ventilation to perfusion ratio, and thickening of the intrapulmonary www.journals.viamedica.pl vascular bed [2,7].…”

Section: Discussionmentioning

confidence: 99%

Dyspnoea, Cyanosis and Digital Clubbing in a 28-Year-Old Patient as a Result of Hepatopulmonary Syndrome

Zieliński

Hartleb

Sitek³

2017

Advances in Respiratory Medicine

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This paper presents a case of a young patient with cyanosis and digital clubbing, until then an active, sporty person. He sought medical assistance due to the growing dyspnoea and the drop of effort tolerance. Initially the diagnostic process focused on the confirmation of the suspicion of pulmonary fibrosis or another interstitial lung disease as causes of the respiratory failure. Due to the atypical presentation of the symptoms, reaching the final diagnosis of digestive system disease with lung involvement required a more thorough multifaceted diagnostics of a number of systems and organs.

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Section: Discussionmentioning

confidence: 99%

Dyspnoea, Cyanosis and Digital Clubbing in a 28-Year-Old Patient as a Result of Hepatopulmonary Syndrome

Zieliński

Hartleb

Sitek³

2017

Advances in Respiratory Medicine

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Impact of Bacterial Translocation on Hepatopulmonary Syndrome: A Prospective Observational Study

et al. 2017

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Hepatopulmonary syndrome is related to the development of acute-on-chronic liver failure and poor prognosis in cirrhotic patients

et al. 2021

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Background & Aims:Long-term prospective data on hepatopulmonary syndrome (HPS) from a large number of patients, especially in Asian patients, are lacking. We evaluated the long-term prognosis of HPS and the development of acute-on-chronic liver failure (ACLF), and related factors. Methods:A total of 142 patients with cirrhosis who underwent saline-agitated contrast echocardiography for the diagnosis of HPS were enrolled and observed prospectively from 2014 to 2019. Results:A total of 59 patients (41%) were diagnosed with HPS (24 grade 1, 23 grade 2, 12 grade 3). Thirty-eight and 37 patients died in the HPS and non-HPS groups, respectively (p < 0.01). The 5-year survival rate was 47% in the HPS group and 62% in the non-HPS group. In the Cox proportional hazards model, HPS and Model for End-stage Liver Disease (MELD) score≥18, and Child-Turcotte-Pugh (CTP) class B/C were signi cant risk factors for mortality after adjusting for other risk factors (HPS hazard ratio [HR] = 1.9, p = 0.01; MELD score≥18 HR = 2.3, p < 0.01; CTP class B/C HR = 2.9, p < 0.01). Compared to that in non-HPS group, the HPS group had a signi cantly higher incidence of ACLF during follow-up (p < 0.01) and more frequently presented with lung involvement of ACLF (p = 0.03). Conclusions:In the long-term follow-up cohort, patients with HPS showed poorer prognosis than that of patients without HPS. HPS was a risk factor for ACLF development independent of hepatic dysfunction, and lung involvement was signi cantly common than without patients Lay SummaryIn this study, patients with cirrhosis diagnosed with hepatopulmonary syndrome had a poor prognosis and higher probability of Acute-on-Chronic failure than those who did not.

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Frequency of Hepatopulmonary Syndrome (HPS) Among Patients With Liver Cirrhosis: A Letter to Editor

Cited by 3 publications

References 11 publications

Dyspnoea, Cyanosis and Digital Clubbing in a 28-Year-Old Patient as a Result of Hepatopulmonary Syndrome

Dyspnoea, Cyanosis and Digital Clubbing in a 28-Year-Old Patient as a Result of Hepatopulmonary Syndrome

Impact of Bacterial Translocation on Hepatopulmonary Syndrome: A Prospective Observational Study

Hepatopulmonary syndrome is related to the development of acute-on-chronic liver failure and poor prognosis in cirrhotic patients

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