Frequency of Homocysteinemia in Young Ischemic Stroke Patients and Its Relationship with the Early Outcome of a Stroke

Abstract

ObjectiveTo find out the frequency of hyperhomocysteinemia in young ischaemic stroke patients and its relationship with early morbidity and mortality.MethodsThis prospective study was conducted on young ischemic stroke patients in Pakistan Atomic Energy Commission General Hospital, Islamabad. Ischaemic stroke patients of age < 45 years were selected from both the outpatient and inpatient departments. A fasting venous blood sample was sent for analysis. Data was collected through a structured proforma and were analyzed using SPSS 24.0 (IBM Corp, Armonk, NY, US). The outcome was measured at discharge using the modified Rankin scale.ResultsThe mean age of the 71 patients in the study was 35.8 years. Overall, 36 (50.7%) cases had hyper-homocysteinemia. The frequency was significantly higher in males and in the age group 36-45 years (63.4%). Levels of homocysteine did not significantly affect the outcome at discharge.ConclusionHyperhomocysteinaemia, a modifiable risk factor for ischaemic stroke, was seen in about half of young stroke patients. The levels of homocysteine did not correlate with early stroke outcome.

Serum Metabolomic Patterns in Young Patients with Ischemic Stroke

“…The present study showed that serum metabolomic patterns were signi cantly different between young patients with ischemic stroke Amino acids are an important group of metabolites that participate in multiple physiological and pathophysiological processes. Consistent with previous studies in older people, the present study showed that young patients with ischemic stroke had signi cantly increased L-methionine, homocysteine, uric acid, and glutamine levels [14][15][16][17]. As is known, both hyperhomocysteinemia and hyperuricemia are independent risk factors for stroke [14][15].…”

“…Consistent with previous studies in older people, the present study showed that young patients with ischemic stroke had signi cantly increased L-methionine, homocysteine, uric acid, and glutamine levels [14][15][16][17]. As is known, both hyperhomocysteinemia and hyperuricemia are independent risk factors for stroke [14][15]. As an essential amino acid, methionine comes from dietary intake.…”

The Role of Potential Oxidative Biomarkers in the Prognosis of Acute Ischemic Stroke and the Exploration of Antioxidants as Possible Preventive and Treatment Options

“…In comparison to the first quarter, there was a gradual quartile rise in the relative stroke risk in the second, third, and fourth quarters of the total homocysteine distribution (odds ratios 1–3, 1–9, 28; trend p = 0–0.05) [ 90 ]. Consistent with prior research in older people, Niazi et al [ 91 ] showed that 50.7% of young ischemic stroke patients exhibited a moderate to high frequency of homocysteine. They also found that homocysteine levels were notably higher in men (mainly in the 36–45 age group) than in women [ 91 ].…”

The Connotation of Variances in the Risk Predictors, Medications, Homocysteine, and Homocysteine Pathway Gene Polymorphisms with CVA/Stroke

“…Homocysteine, a novel risk factor is strongly associated with CAD and stroke, with elevated levels of stroke associated with stroke risk in young. 35 Hyperhomocysteinemia was associated with stroke in current study as well ( p = 0.008) with significant difference when controls were compared with TIA, or with CVA cases. The odds of stroke were highly significant in hypertensive patients, following regression analysis.…”