Frequency of Human Papilloma Virus (HPV) subtypes 31,33,35,39 and 45 among Yemeni women with cervical cancer

Ahmed, Hussain Gadelkarim; Bensumaidea, Saleh Hussein; Ashankyty, Ibraheem

doi:10.1186/s13027-015-0026-9

Cited by 34 publications

(35 citation statements)

References 19 publications

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“…Cervical cancer is the most common cancer among women in 45 different countries; these include countries in sub-Saharan Africa, Asia, including India, and certain Central and South American countries ( 3 ). A variety of factors contribute to cervical cancer occurrence and development; for example, the high-risk human papilloma virus ( 4 , 5 ). Cervical cancer susceptibility is also increased by host genetic factors ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein in cervical cancer and correlation with squamous cell carcinoma antigen

et al. 2017

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Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein (DC-SIGNR) is a type II transmembrane protein that has been reported to bind to various pathogens and participate in immunoregulation and tumorigenesis. However, further research is required to investigate whether the level of DC-SIGNR and cervical cancer are associated. The present study aimed to explore the clinical diagnostic significance of DC-SIGNR in cervical cancer. Immunohistochemical staining of DC-SIGNR was performed in samples from 25 patients with early stage cervical cancer, 14 patients with cervical intraepithelial neoplasia (CIN) and cervical polyp samples from 15 individuals. DC-SIGNR expression in cervical cancer tissue was significantly higher compared with that in CIN and cervical polyp tissue (P=0.0184 and P=0.0236, respectively). However, there was no significant difference in DC-SIGNR expression between CIN and cervical polyp tissue (P=0.8103). Additionally, the serum DC-SIGNR levels in 84 cervical cancer patients and 69 healthy female individuals were measured using an ELISA. Serum (s)DC-SIGNR levels were significantly higher in cervical cancer patients compared with healthy female individuals (P<0.0001). A sDC-SIGNR level of 93.7 ng/ml was revealed by receiver operating characteristic curve analysis to predict the presence of cervical cancer with 69.57% sensitivity and 66.67% specificity (area under the curve, 0.6989; P<0.0001). Levels of sDC-SIGNR in cervical cancer patients were also correlated with serum levels of squamous cell carcinoma antigen (r=0.2583; P=0.0348). The results of the present study demonstrate that DC-SIGNR is overexpressed in cervical cancer tissue, and suggest that DC-SIGNR could serve as a biomarker for the early diagnosis of cervical cancer. Nevertheless, further studies are required to demonstrate what role DC-SIGNR serves in cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Overexpression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein in cervical cancer and correlation with squamous cell carcinoma antigen

et al. 2017

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“…The recently FDA approved 9-valent vaccine provides immunity to HPV31, 33, 45, 52, and 58 in addition to 6, 11, 16, and 18; this does not cover HPV39, or HPV35 which are highrisk types, but these types are thought to rarely lead to cervical cancer [11]. Of note, there has been some important evidence that indicates HPV39 may be associated with anal cancers [12] as well as cervical cancers in certain ethnic groups [13,14]. This was one of the most common types of HPV found in our diverse study population, and anal cancers are increasing in prevalence.…”

Section: Discussionmentioning

confidence: 99%

Concurrent Infections With Human Papillomavirus and Cervical Intraepithelial Lesions: What Is the Relationship?

Seo¹,

Rawlinson²,

Messersmith³

et al. 2017

J Clin Gynecol Obstet

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Background: Human papillomavirus (HPV) infection is necessary for cervical dysplasia and cervical cancer to develop, but infection with HPV is not predictive of which women will develop cervical squamous intraepithelial lesions (SILs) or cancer. This study examines the relationship between the number of concurrent HPV infections and risk of SIL as well as the variations in HPV types in a diverse population.

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“…La e6 se une a la ubiquitina celular, unión que resulta en la ubiquitinización de p53 con la subsecuente degradación proteolítica [4,[7][8][9]. Se conocen al menos 200 subtipos de vph, y se dividen en virus de bajo y alto riesgo, tal como se muestra en la tabla 1 [10][11][12].…”

Section: Introductionunclassified

Virus del papiloma humano, sus implicaciones en cavidad bucal; una revisión de la literatura

et al. 2018

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Introducción: el dar a conocer las principales características clínicas de la afectación de algunos virus del papiloma humano en cavidad bucal, permite al profesional de la salud identificar factores de riesgo y las principales lesiones asociadas con el mismo, con el fin de brindar atención oportuna, evitando de esta manera el pasar por alto este tipo de lesiones.Características: el virus del papiloma humano (VPH) pertenece a la familia de los Papillomaviridae que mide entre 50-55 nm de diámetro, son virus pequeños de ADN no envueltos, epiteliotrópicos cuyo genoma está formado por cadenas dobles de cADN, este virus se puede llegar a encontrar de forma latente en el organismo durante años sin evidenciar cambios histológicos o clínicos, o bien puede formar papilomas benignos o verrugas cuyas lesiones consisten en tejido hiperplásico con engrosamiento de la capa espinosa del epitelio y un aumento de la proliferación capilar.Resultados: al tratarse de un virus exclusivamente epiteliotrópico la vía de entrada ocurre a través de micro-rupturas del epitelio que expone a las células de la superficie basal al virus, lo cual explica la alta frecuencia con la que se presenta en las poblaciones.Conclusiones: el odontólogo de práctica general debe conocer las generalidades de los virus VPH, de tal manera que cuando identifiquen alguna lesión relacionada con algunos de los subtipos, pueda orientar al paciente y ofrecer un tratamiento acertado cuando así se requiera

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Frequency of Human Papilloma Virus (HPV) subtypes 31,33,35,39 and 45 among Yemeni women with cervical cancer

Cited by 34 publications

References 19 publications

Overexpression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein in cervical cancer and correlation with squamous cell carcinoma antigen

Overexpression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein in cervical cancer and correlation with squamous cell carcinoma antigen

Concurrent Infections With Human Papillomavirus and Cervical Intraepithelial Lesions: What Is the Relationship?

Virus del papiloma humano, sus implicaciones en cavidad bucal; una revisión de la literatura

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