Frequency of “incidental” serous tubal intraepithelial carcinoma (STIC) in women without a history of or genetic risk factor for high-grade serous carcinoma: A six-year study

Meserve, Emily E.K.; Mirković, Jelena; Conner, James; Yang, Eric J.; Muto, Michael G.; Horowitz, Neil S.; Strickland, Kyle C.; Howitt, Brooke E.; Crum, Christopher P.

doi:10.1016/j.ygyno.2017.04.015

Cited by 38 publications

(23 citation statements)

References 25 publications

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“…4b). Our finding supports the unconfirmed hypothesis that secretory epithelial cells of the distal fallopian tube represent the COO of high-grade serous Ovary-AdenoCA [25][26][27] and not the epithelium of the ovaries 28 . In contrast to previous work in this area, our approach can associate high-grade serous Ovary-AdenoCA with the epithelium of the fallopian tube without specifying pre-invasive lesions.…”

Section: Fallopian Tube Best Matches High-grade Serous Ovarian Cancersupporting

confidence: 87%

Tumor mutational landscape is a record of the pre-malignant state

Kübler

Haradhvala

et al. 2019

Preprint

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Chromatin structure has a major influence on the cell-specific density of somatic mutations along the cancer genome. Here, we present a pan-cancer study in which we searched for the putative cancer cell-of-origin of 2,550 whole genomes, representing 32 cancer types by matching their mutational landscape to the regional patterns of chromatin modifications ascertained in 104 normal tissue types. We found that, in almost all cancer types, the cell-of-origin can be predicted solely from their DNA sequences. Our analysis validated the hypothesis that high-grade serous ovarian cancer originates in the fallopian tube and identified distinct origins of breast cancer subtypes. We also demonstrated that the technique is equally capable of identifying the cell-of-origin for a series of 2,044 metastatic samples from 22 of the tumor types available as primaries. Moreover, cancer drivers, whether inherited or acquired, reside in active chromatin regions in the respective cell-of-origin. Taken together, our findings highlight that many somatic mutations accumulate while the chromatin structure of the cell-of-origin is maintained and that this historical record, captured in the DNA, can be used to identify the often elusive cancer cell-of-origin.

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Section: Fallopian Tube Best Matches High-grade Serous Ovarian Cancersupporting

confidence: 87%

Tumor mutational landscape is a record of the pre-malignant state

Kübler

Haradhvala

et al. 2019

Preprint

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“…Three serous tubal intraepithelial cancers were found, 2 in BRCA-negative patients. This rate is higher than rates previously published for the general population [11]. Among the uterine specimens, 1 endometrial adenocarcinoma and 1 multifocal endometrial intraepithelial neoplasia were noted.…”

Section: Discussioncontrasting

confidence: 60%

Surgical Findings and Outcomes in Premenopausal Breast Cancer Patients Undergoing Oophorectomy: A Multicenter Review From the Society of Gynecologic Surgeons Fellows Pelvic Research Network

Harvey

Abramson

Alvarez

et al. 2018

Journal of Minimally Invasive Gynecology

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Since publication of the Suppression of Ovarian Function Trial data, bilateral oophorectomy has been recommended for some women with premenopausal breast cancer to facilitate breast cancer treatment with aromatase inhibitors. These women may be at elevated risk for occult abdominal pathology compared with the general population. Gynecologic surgeons often perform castration oophorectomy in patients with breast cancer as an increasing number of oncologists are using aromatase inhibitors to treat premenopausal breast cancer. Our data suggest that other abdominal/pelvic cancers, precancerous conditions, and previously unrecognized metastatic disease are not uncommon findings in this patient population. Gynecologists serving this patient population may consider a careful abdominal survey, pelvic washings, endometrial sampling, and serial sectioning of fallopian tube specimens for a thorough evaluation.

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“…In contrast, STIC may be a putative precursor of HGSC [27]. STIC was observed only in 0.1-0.8% of low-risk women, such as women without a history of or known risk factors (BRCA mutation) for HGSC [28,29]. Another study reported that the incidence of STIC in women without BRCA mutation was much higher, 3%; in that study 8% of women with BRCA mutation had a STIC [30].…”

Section: High-grade Serous Carcinogenesismentioning

confidence: 81%

Screening and Prevention for High-Grade Serous Carcinoma of the Ovary Based on Carcinogenesis—Fallopian Tube- and Ovarian-Derived Tumors and Incessant Retrograde Bleeding

Otsuka

Matsuura

2020

Diagnostics

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High-grade serous carcinoma (HGSC) is the most common and lethal subtype of ovarian carcinoma. Many HGSCs are now believed to originate in the fallopian tube epithelium; ovarian surface epithelium is another possible origin. Thus, current screening methods, i.e., ultrasonography and serum CA-125 measurements, have a limitation in their early detection. Recently, circulating biomarkers, such as tumor DNA, autoantibody, and microRNA, have been investigated to detect HGSCs. As cancer cells in the fallopian tube flow into the endometrial cavity, the detection of exfoliated cells, tumor DNA, and proteome from samples obtained from the endometrial cavity or the cervix may be useful. The risk of ovarian serous carcinoma is affected by the use of oral contraceptive and menopausal hormone therapy (MHT). MHT regimens causing endometrial bleeding increase serous carcinoma risk, hence, incessant retrograde bleeding from the endometrial cavity into the Douglas pouch appears to play an important role in high-grade serous carcinogenesis. In this review, we provide an overview of current and novel screening methods and prevention approaches for ovarian and fallopian tube HGSC.

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Frequency of “incidental” serous tubal intraepithelial carcinoma (STIC) in women without a history of or genetic risk factor for high-grade serous carcinoma: A six-year study

Cited by 38 publications

References 25 publications

Tumor mutational landscape is a record of the pre-malignant state

Tumor mutational landscape is a record of the pre-malignant state

Surgical Findings and Outcomes in Premenopausal Breast Cancer Patients Undergoing Oophorectomy: A Multicenter Review From the Society of Gynecologic Surgeons Fellows Pelvic Research Network

Screening and Prevention for High-Grade Serous Carcinoma of the Ovary Based on Carcinogenesis—Fallopian Tube- and Ovarian-Derived Tumors and Incessant Retrograde Bleeding

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