Frequency of infections caused by ESBL-producing bacteria in pediatric ward – single center five-year observation

Abstract

Introduction Infections caused by Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs) are a serious therapeutic and clinical problem. An increasing role of ESBL(+) pathogens is observed in both community- and hospital-acquired infections. The aim of the study was to assess the incidence and the risk factors for ESBL(+) bacteria infection in a pediatric ward during a 5-year period. Material and methods The medical documentation data of patients hospitalized in the Department of Pediatrics, Pediatric Nephrology and Allergology between 2011 and 2015 were subjected to a retrospective analysis. Cases of ESBL(+) bacterial infections were analyzed in detail. Results 0.57% (46) of all the hospitalizations (8015) during the 5-year observation period in our department were caused by ESBL (+) pathogens. It constituted 8.5% of all positive microbiological cultures obtained. The analysis revealed an increasing trend in the number of ESBL (+) infections throughout the observed period. 43.5% of patients were only asymptomatic carriers. In 71.7% urinary tract structural and functional abnormalities were present. 76.1% of patients had been hospitalized previously and 60.9% had undergone urinary tract invasive procedures. Conclusions The results confirm the rising trend of ESBL (+) infections during the observed period. ESBL (+) bacteria were isolated primarily in previously hospitalized children with particular reference to urinary tract invasive procedures during hospitalizations. Moreover, the study showed that patients with urogenital disorders and non-urinary chronic diseases are more susceptible to these priority pathogen infections.

Evaluation of Bacterial Infections in Bahraini Pediatric Patients From A Tertiary Care Hospital – A Prospective Study

“…Urine and throat cultures were maximum in number, indicating the presence of opportunistic organisms. However, there are numerous studies that show the intake of different cultures depending on the symptoms of bacterial infection which can lead to ignorance of other underlying infections/causes of diseases 21,[27][28][29]. Gram-positive isolates were highly susceptible to amoxicillin and trimethoprim/sulfamethoxazole, whereas Gram-negative isolates were more susceptive to gentamicin and ciprofloxacin, which is unique in this study.…”

“…The present research showed a high prevalence of ESBL, Campylobacter sp., MRSA under the age group of 0-4 years in both genders. In a five-year study, children of mean age 5.35 years reported how ESBL was the most common bacteria causing UTI, hospitalization, bacterial resistance 21. Similarly,Rezai et al(2015) illustrated that 30.5% of isolated E. coli was ESBL-producing strain 22.…”

Genomic signatures in pediatric advanced stage Burkitt lymphoma/leukemia in a Chinese population detected by next generation sequencing

“…sBL/BAL is highly aggressive but curable subtype of lymphoma. With combination treatment of chemotherapy and rituximab, the survival rate of sBL/BAL has improved steadily although severe infection, included enterobacteriaceae producing extended-spectrum-lactamases, were common [23], but additional research into its pathogenetic mechanisms is necessary. The molecular hallmark of sBL/BAL is MYC translocation, but additional chromosomal abnormalities and gene mutations also occur and play roles in the progression of the disease.…”

Influence of childhood overweight and obesity on foot and lower limb pain in a population of primary school children

“…Further studies of issues related to childhood obesity and foot pain, based on a longitudinal and analytical design, are necessary. In addition, health-related quality of life or even in another chronic diseases as the case of arthritis rheumatoid, risk of fall or infection can be affected by obesity in the general population or children [32][33][34].…”