Frequency of iron deficiency anemia in type 2 diabetes - Insights from tertiary diabetes care centres across India

Pradeepa, Rajendra; Shreya, Lal; Anjana, Ranjit Mohan; Jebarani, Saravanan; Raj, Nithyanantham Kamal; Madhan, Srinivasan Kumar; Jayaganesh, Parthasarathy; Swami, Onkar C; Mohan, Viswanathan

doi:10.1016/j.dsx.2022.102632

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…In the univariable and multivariable MR study, we systematically assessed the iron de ciency anemia with type 2 diabetes, ulcerative colitis and Crohn's disease risk. Consistent with previous research results 5,[9][10][11]28 , our ndings demonstrated a signi cant positive association between IDA and an increased risk of both T2DM and CD. Furthermore, our multivariable MR analysis substantiated a direct causal relationship between T2DM and IDA, while accounting for the confounding effects of other related diseases.…”

Section: Discussionsupporting

confidence: 92%

“…IDA poses a signi cant burden among patients hospitalized for Crohn's disease, as shown by a large cohort study conducted in the United States 5 ; another observational study focusing on patients with in ammatory bowel disease (IBD) revealed that approximately one-fth of the cohort experienced anemia primarily due to ID 6 ; recent guidelines from the European Crohn's Disease and Colitis Organization underline the importance of regular screening and prompt treatment for IDA in individuals with IBD 7 ; a recent study reported varying prevalence rates of ID in hospitalized IBD patients, ranging from 13-90%, with an average of 23% 8 . In the context of type 2 diabetes mellitus (T2DM), a retrospective study involving 1,137 patients found that 39.3% had ID, with ID being most prevalent (61.7%) among those with a duration of diabetes less than 5 years 9 ; another study demonstrated an association between IDA and elevated glycosylated hemoglobin concentrations, which signi cantly declined following iron treatment 10 .…”

Section: Introductionmentioning

confidence: 99%

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Causal association between type 2 diabetes mellitus, inflammatory bowel disease and iron deficiency anemia: A multivariable Mendelian randomization Study

Yang,

Gao,

Wang

et al. 2024

Preprint

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Purpose To investigate the casual role of type 2 diabetes mellitus(T2DM) and inflammatory bowel disease (IBD) in iron deficiency anemia (IDA). Methods Univariable and multivariable Mendelian randomization (MR) analyses were conducted to evaluate the associations of T2DM, ulcerative colitis (UC) and Crohn's disease (CD) with risks for IDA. Results CD and T2DM were found to be associated with IDA in all three diseases. The ORs were 1.035(95% CI 1.006–1.064; p = 0.049) for CD and 1.086(95% CI 1.004–1.168; p = 0.022) for T2DM, respectively. Furthermore, when assessing CD and T2DM simultaneously using multivariable MR, both were found to be associated with an increased risk of IDA (OR 1.039, 95% CI 1.001–1.069, p = 0.012; OR 1.100, 95% CI 1.034–1.166, p = 0.005). But considering the effects of UC and CD in multivariable MR, only T2DM was causally associated with IDA (OR 1.104, 95% CI 1.037–1.171, p = 0.004). Conclusion Associations were found in the incidence of IDA and an increased risk of T2DM and CD, highlighting the importance of IDA prevention in patients with T2DM and CD.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Causal association between type 2 diabetes mellitus, inflammatory bowel disease and iron deficiency anemia: A multivariable Mendelian randomization Study

Yang,

Gao,

Wang

et al. 2024

Preprint

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“…There is a need of identifying and monitoring of iron status and anemia in patients with T2DM. 21 Recently published systematic review and meta-analysis showed that anemia is a moderate to severe public health problem among adult populations living with diabetes, with the prevalence of 22% in Ethiopia, 35% in Africa, and 45% in South Asia. 20,22,23 Despite a growing body of research on these problems, there is a lack of synthesized evidence on the burden of anemia among people with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Global Prevalence of Anemia Among Type 2 Diabetic Adult Patients: A Systematic Review and Meta-Analysis

Arkew,

Asmerom,

Gemechu

et al. 2023

DMSO

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Background: Anemia is a common and often overlooked hematological change observed in patients with diabetes mellitus. However, there is no global survey or health registry that estimates the pooled prevalence of anemia in patients with type 2 diabetes. Therefore, this study aimed to determine the global pooled prevalence of anemia among adult patients with type 2 diabetes. Methods: This study was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The study protocol was registered on PROSPERO with the reference number (CRD42022327135), and the link provided (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022327135) display the published methodology. Previously published articles were searched in PubMed/Medline, Cochrane Library, WHO Global Index Medicus, African Journals Online, ScienceDirect, Google Scholar, and Google from October 26 to November 09, 2022. The quality of the included studies was assessed using the Joanna Briggs Institute Critical Appraisal tool. Random-effects model was used to estimate the pooled prevalence of anemia. The degree of heterogeneity among the included studies was assessed using I 2 statistics. Publication bias was detected using funnel plot symmetry analysis supplemented by Egger's and Begg's tests. Results: Twenty-four studies with a total number of 19,118 participants were included in this systematic review and meta-analysis. The overall pooled prevalence of anemia among type 2 diabetic adult patients was 27.0% (95% CI: 24.0, 31.0, I 2 = 96.45%; P< 0.001). Geographical and time-based subgroup analysis showed that higher prevalence of anemia was observed in Africa region 28.0% (95% CI: 17.0, 39.0) and from 2015 to 2022, 28.0% (95% CI: 24.0, 33.0), respectively. Conclusion: Anemia is a moderate public health problem among adult patients with type 2 diabetes. Nearly one in four patients with type 2 diabetes develops anemia. Therefore, considering the negative impact of anemia, it is important to include anemia screening in the routine assessment of diabetes-related complications.

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“…[25] The difference in amplitude of the absorption coefficient is due to the decreased concentrations of heme in glycated hemoglobin. [14] Anemia or iron deficiency is commonly observed in diabetes patients [26,27] and a positive correlation has been observed with heme loss and HbA1c level. As observed from the UV-vis spectra of in-vivo Hb and GHb, Fe always lies in its Fe(III) state [28] .…”

Section: Resultsmentioning

confidence: 99%

A Mutagen Acts as a Potent Reducing Agent of Glycated Hemoglobin: a Combined Ultrafast Electron Transfer and Computational Studies

Roy,

Pan,

Ghosh

et al. 2024

ChemBioChem

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Glycated hemoglobin (GHb) found in mammals undergoes irreversible damage when exposed to external redox agents, which is much more vulnerable than its normal counterpart hemoglobin (Hb). Besides the oxygen regulation throughout the body, Hb plays a vital role in balancing immunological health and the redox cycle. Photoinduced ultra‐fast electron transfer phenomena actively participate in regulation of various kind of homeostasis involved in such biomacromolecules. In the present study we have shown that a well‐known mutagen Ethidium Bromide (EtBr) reduces GHb in femtosecond time scale (efficiently) upon photoexcitation after efficient recognition in the biomolecule. We have performed similar experiment by colocalizing EtBr and Iron (Fe(III)) on the micellar surface as Hb mimic in order to study the excited state EtBr dynamics to rationalize the time scale obtained from EtBr in GHb and Hb. While other experimental techniques including Dynamic Light Scattering (DLS), Zeta potential, absorbance and emission spectroscopy have been employed for the confirmation of structural perturbation of GHb compared to Hb, a detailed computational studies involving molecular docking and density functional theory (DFT) have been employed for the explanation of the experimental observations.

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Frequency of iron deficiency anemia in type 2 diabetes - Insights from tertiary diabetes care centres across India

Cited by 9 publications

References 22 publications

Causal association between type 2 diabetes mellitus, inflammatory bowel disease and iron deficiency anemia: A multivariable Mendelian randomization Study

Causal association between type 2 diabetes mellitus, inflammatory bowel disease and iron deficiency anemia: A multivariable Mendelian randomization Study

Global Prevalence of Anemia Among Type 2 Diabetic Adult Patients: A Systematic Review and Meta-Analysis

A Mutagen Acts as a Potent Reducing Agent of Glycated Hemoglobin: a Combined Ultrafast Electron Transfer and Computational Studies

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