Spasticity may result from either diffuse or localized pathology of the cerebral cortex, brain stem, or spinal cord. Possible causes of such injuries include traumatic brain injury, stroke, multiple sclerosis, spinal cord trauma, or disease and anoxic insults. The neurologic localization of the lesion causing spasticity may result in different clinical manifestations. Thus, it is important to consider whether the spasticity results from cerebral pathology, whether it is diffuse or localized, or whether it is a result of spinal cord injury. Diffuse cerebral injury or diseases would include anoxia, toxic, or metabolic encephalopathy, where as localized cerebral injury would include tumor, abscess, cyst, arteriovenous malformations, hemorrhage, or trauma.