Frequency of Lymphomatous Infiltration of Hodgkin’s & Non-Hodgkin’s Lymphoma in Bone Marrow by Bone Marrow Aspiration, Trephine Biopsy and Clot Section

Abstract

Background: Lymphomas are malignant neoplasm of lymphoid cells, classified broadly in Hodgkin's and Non Hodgkin's lymphoma and have variable tendency to metastasize to blood and bone marrow depending on their types. Methods: We performed bone marrow aspiration and biopsy on known patients of lymphoma diagnosed on Lymph node cytology or biopsy in the Department of Pathology King Georges Medical University along with general blood work up to know the incidence of various lymphomatous infiltrations and also to compare different procedure for their effectiveness. Patients already on treatment, relapsed cases of lymphoma and patients below 10 yrs of age group were excluded from the study. After taking proper history and consent, general examination and bone marrow procedure was done and clot section was also made. Results: We found that males were more commonly involved than females in both the type of lymphomas with majority of cases in both lymphoma group showed bimodal age distribution that is below 30 yrs and after 40 yrs. Most common type to infiltrate bone marrow was lymphoblastic lymphoma (75%) followed by large cell types and small cell types with equal frequencies of (66.7%). Bone marrow aspiration, clot section and biopsy did not show any statistical significant differences in the efficacy. Conclusion: lymphoma frequently metastasizes in the bone marrow and its frequency depends on the type of lymphoma.