Frequency of micronucleated exfoliated cells in oral lichen planus

Buajeeb, Waranun; Kraivaphan, Petcharat; Amornchat, Cholticha; Triratana, Terdphong

doi:10.1016/j.mrgentox.2006.10.010

Cited by 29 publications

(16 citation statements)

References 28 publications

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“…This study was undertaken on 21 patients with OLP (diagnosed according to the revised, modified World Health Organization 1979 diagnostic criteria). Their mean age was 54.7 ± 9.2 years and each had clinical severity score of 2 or below (34). A total of 20 healthy subjects free of oral mucosal disease and matched to the periodontal status of the case series were recruited as controls (mean age: 33.7 ± 6.9 years).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus

Ergün

Trosala

Warnakulasuriya

et al. 2010

Journal of Oral Pathology &Amp; Medicine

102

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Section: Methodsmentioning

confidence: 99%

Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus

Ergün

Trosala

Warnakulasuriya

et al. 2010

Journal of Oral Pathology &Amp; Medicine

102

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“…The findings of Sivasankari et al (2008) were similar to that in our study where MN% was highest in SMF patients followed by leukoplakia and lichen planus, whereas in a study done by Dindgire et al (2012) MN% was found to be highest in OSMF patients followed by lichen planus and leukoplakia cases. [18,19] The levels of mean MN in PMDs such as leukoplakia, OSMF, and lichen planus compared to that of controls show a statistically significant difference in various studiesdone by Grover et al, Koneru [8,9,[20][21][22] According to Samanta and Dey (2010), the various possible explanations for MN formation in these lesions include chromosomal aberrations, chromosome loss/breakage, mitotic apparatus dysfunctions, aneuploidy, and genetic instability. [4] Variations in MN counts in different studies can be attributed to ingredients in the quid, the number of quids per day and the different lifestyles and food habits of people as these studies were conducted in different populations.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Micronucleus Frequencies in Exfoliated Buccal Cells of Potentially Malignant Disorder Subjects Using Feulgen Stain

2019

IJDA

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Introduction:Oral squamous cell carcinoma generally arises from oral potentially malignant disorders (OPMDs) through a complex process of genetic alterations such as chromosomal alterations, epigenetic alterations, and/or DNA changes. If these lesions are detected in early stages, i.e., during stage of PMDs through specific and sensitive tests, it can markedly improve the survival rates of patients. Micronucleus (MN) is one such suitable and reliable test to detect genotoxic effects of various carcinogens. Aims: The aim of the present study was to evaluate and compare the levels of micronuclei in OPMDs as well as to correlate micronuclei frequency in different grades of dysplasia. Materials and Methods: The study cases were divided into two groups, Group I consisting of thirty healthy controls and Group II of thirty histopathologically proven cases of OPMDs. The exfoliated cells were collected from buccal mucosa/lesional area of both study groups and were stained with Feulgen stain and evaluated under microscope for MN. Statistical analysis was done using ANOVA test and correlation was calculated using Pearson's correlation using SPSS 18.0 software. Results: According to the present study, MN and MN percentage (MN%) increased from normal to potentially malignant disorder cases with statistically significant difference. A highly positive correlation (0.946) between grades of dysplasia and MN formation was obtained. Conclusion: The present study concludes that the occurrence of MN and MN% increases from controls to potentially malignant disorder cases. Among PMDs, the occurrence of MN and MN% was highest in patients of oral submucous fibrosis followed by leukoplakia and lichen planus patients. And finally, with increase in grades of dysplasia, in PMD subjects, the formation of MN increases.

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“…Earlier studies have demonstrated genotoxic damage in OLP patients, and the MN frequency in OLP lesions is greater than that in healthy controls (Buajeeb et al, 2007;Saran et al, 2008). In OLP, cytogenetic damage is not only present in exfoliated oral mucosal cells, but is also found in circulating lymphocytes of patients with OLP (Desai et al, 1996).…”

Section: Introductionmentioning

confidence: 88%

Evaluation of micronuclear frequencies in both circulating lymphocytes and buccal epithelial cells of patients with oral lichen planus and oral lichenoid contact reactions

et al. 2013

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Micronuclei scores do not distinguish OLP from OLCR when using buccal smears. OLP and OLCR both demonstrated significantly higher MN frequencies in buccal cells, compared with healthy controls. MN assessment in both buccal epithelial cells and circulating lymphocytes may serve as a potential biomarker tool for evaluating any cancer risk in OLP and OLCR. [Correction added on 30 May 2014, after first online publication: the first and second sentences in the conclusions have been slightly changed.].

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Frequency of micronucleated exfoliated cells in oral lichen planus

Cited by 29 publications

References 28 publications

Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus

Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus

Evaluation of Micronucleus Frequencies in Exfoliated Buccal Cells of Potentially Malignant Disorder Subjects Using Feulgen Stain

Evaluation of micronuclear frequencies in both circulating lymphocytes and buccal epithelial cells of patients with oral lichen planus and oral lichenoid contact reactions

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