Frequency of Multidrug-Resistant, Extensively Drug-Resistant, and Pandrug-Resistant Phenotypes among Clinical Isolates of Staphylococcus aureus

Sadat, Shahrbanoo Sadat; Azari, Ania Ahani

doi:10.29252/iem.6.4.269

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…In the present study, more than half of S. aureus isolates from impetigo, and 40.8% of those from all skin infections were MRSA. These findings are in line with the findings of a previous study in Iran (13). Similarly, two other studies in Iran reported that more than half of all isolates from skin infections were MRSA (14,15).…”

Section: Discussionsupporting

confidence: 92%

The Glycopeptide-Susceptibility of Multidrug-Resistant/Extensively Drug-Resistant Staphylococcus aureus in Skin Infections

Hosseini,

Fozouni

2023

Middle East J Rehabil Health Stud

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Background: The prevalence of drug-resistant Staphylococcus aureus is increasing alarmingly, limiting treatment options. Objectives: This study was conducted to investigate the minimum inhibitory concentration (MIC) of glycopeptides against multidrug-resistant (MDR) and extensively drug-resistant (XDR) S. aureus isolates from patients with skin infections. Methods: In this study, S. aureus isolates were collected from outpatients with skin infections (n = 250) during 2019 - 2022. The isolates were identified using routine microbiological and biochemical tests. Susceptibility to ten categories of antibacterial agents was assessed using the Kirby-Bauer method according to the Clinical and Laboratory Standards Institute M100 guidelines (2021). The MIC of glycopeptides was determined using the broth microdilution test. Results: Among methicillin-resistant S. aureus isolates (40.8%), the majority were from patients with impetigo (53.92%). The highest resistance rate was observed against penicillin (79.41%) and doxycycline (73.52%). Linezolid showed significant inhibitory properties against XDR (91%) and MDR (97%) S. aureus isolates (P = 0.01). The MIC of oritavancin that inhibited the growth of 90% of the MDR isolates (MIC90) was 2 µg/mL, which was eight times less than that of vancomycin (MIC90 = 16 µg/mL) and 16 times lower than that of teicoplanin (MIC90 = 32 µg/mL) in a manner that 91% of MDR isolates from impetigo were eliminated at concentrations 2 µg/mL. Oritavancin inhibited the growth of 54.5% of XDR isolates at MIC concentrations of ≥8 µg/mL. Conclusions: Considering the strong antibacterial activity of linezolid against MDR S. aureus isolates, this antibiotic can effectively treat skin infections caused by S. aureus and prevent the development of resistance to other antibiotics. In addition, considering the great inhibitory properties of oritavancin against MDR S. aureus strains, the efficacy of this agent for treating skin infections, particularly impetigo, should be investigated.

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Section: Discussionsupporting

confidence: 92%

The Glycopeptide-Susceptibility of Multidrug-Resistant/Extensively Drug-Resistant Staphylococcus aureus in Skin Infections

Hosseini,

Fozouni

2023

Middle East J Rehabil Health Stud

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“…Different concentrations of the extract (25, 12.5, 6.25, 3.12 mg/mL) were prepared by serial dilution method [10] . Microorganisms: The antibacterial effect of each extract at different concentrations was assessed against MRSA (n=24) and MDR P. aeruginosa (n=16) isolates from our previous study [11][12] . In previous study, methicillin resistance was evaluated using 30 μg cefoxitin disk (≤21 mm indicated MRSA) and 1 μg oxacillin disk (≤10 mm indicated MRSA) [13] .…”

Section: Plant Materials and Preparation Of Extractsmentioning

confidence: 99%

“…A review of the bioactivity and potential ... [9] Izadi Z, Modarres Sanavi SAM, Sorooshzadeh A, Esna-Ashari M, Davoodi P. Antimicrobial activity of chamomile (Matricaria chamomilla L.) and feverfew (Tanacetum parthenium L.). Armaghane-Danesh J Yasuj .... [10] Imeni N, Qayami Rad M. In vitro antibacterial effect of ethanolic extract of Calendual officinalis L. against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas ... [11] Poudineh F, Ahani Azari A, Fozouni L. Incidence of multidrug-resistant, extensively ... [12] Sadat SS, Ahani Azari A. Frequency of multidrugresistant, extensively ...…”

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confidence: 99%

Antibacterial Effect of Matricaria chamomilla Alcoholic Extract against Drug-Resistant Isolates of Staphylococcus aureus and Pseudomonas aeruginosa

Azari

Danesh

2021

IEM

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Progress and prospects of nanomaterials against resistant bacteria

Hong²,

Xie

et al. 2022

Journal of Controlled Release

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Frequency of Multidrug-Resistant, Extensively Drug-Resistant, and Pandrug-Resistant Phenotypes among Clinical Isolates of Staphylococcus aureus

Abstract: How to cite this article Sadat S.S., Ahani Azari A. Frequency of Multidrug-Resistant, Extensively Drug-Resistant, and Pandrug-Resistant Phenotypes among Clinical Isolates of Staphylococcus aureus.

Cited by 5 publications

References 15 publications

The Glycopeptide-Susceptibility of Multidrug-Resistant/Extensively Drug-Resistant Staphylococcus aureus in Skin Infections

The Glycopeptide-Susceptibility of Multidrug-Resistant/Extensively Drug-Resistant Staphylococcus aureus in Skin Infections

Antibacterial Effect of Matricaria chamomilla Alcoholic Extract against Drug-Resistant Isolates of Staphylococcus aureus and Pseudomonas aeruginosa

Progress and prospects of nanomaterials against resistant bacteria

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