Frequency of Organophosphate Poisoning and its Outcome in SKBZ AK CMH Muzaffarabad

Ishfaq, Sidra; Nazir, Munazza; Bukhari, Sajid; Ahmed, Naeem; Ubaid, Muhammad Furqan; Farooq, Humza

doi:10.53350/pjmhs211592390

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…OP poisoning is common but rarely fatal and has a good outlook. Early treatment can boost the patient’s chances of survival 5 . OP poisoning can cause different symptoms depending on the receptor affected, the duration of exposure, or the organ system involved 3 .…”

Section: Discussionmentioning

confidence: 99%

Severe acute organophosphate poisoning managed with 2-month prolonged atropine therapy: a case report

Bashyal,

Yadav,

Deo

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and Importance: Organophosphate (OP) poisoning is a common and potentially fatal condition that requires prompt and aggressive treatment with atropine, oximes, and supportive care. We report a rare case of OP poisoning that needed high doses of atropine and intensive care for 60 days. Case Presentation: A 39-year-old male ingested 200 ml of chlorpyrifos, an OP compound, and presented with vomiting and epigastric pain. He received an initial dose of atropine of 60 ml (36 mg, 1 ml=0.6 mg), followed by an infusion of 16 ml/h (9.6 mg/h). He developed hypoxia, cardiac arrest, delirium, fever, and persistent bronchorrhea. He was intubated, resuscitated, and transferred to ICU, where he continued showing signs of OP excess and therefore, he received up to 170 ml/h (102 mg/h) of atropine infusion, along with triple inotropes and sedation. He underwent tracheostomy and gradual weaning of atropine. He recovered completely and was discharged in stable condition. Clinical Discussion: This case demonstrates the need for prolonged monitoring of patients with OP poisoning wherein the patient can develop signs of OP excess even after initial atropinization, the effectiveness of multiple doses of atropine in OP poisoning, and the importance of monitoring for complications associated with a prolonged hospital stay. It also shows the potential need for prolonged atropine therapy and intensive care in OP poisoning. Conclusion: OP poisoning can be life-threatening and requires early and aggressive treatment with atropine, oximes, and supportive care. Clinicians should be aware of the potential need for prolonged atropine therapy in OP poisoning cases to improve the chances of survival.

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Section: Discussionmentioning

confidence: 99%

Severe acute organophosphate poisoning managed with 2-month prolonged atropine therapy: a case report

Bashyal,

Yadav,

Deo

et al. 2023

Annals of Medicine &Amp; Surgery

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Albuterol as an adjuvant in acute anticholinesterase pesticide poisoning: a randomized, placebo-controlled clinical trial

Zein-Elabdeen,

Hassan,

El-Ebiary

et al. 2024

Toxicology Research

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Acute anticholinesterase pesticide poisoning is a serious clinical problem, particularly in developing countries. Atropine is the most acceptable treatment for acute anticholinesterase poisoning. However, it only stops fluid production. Albuterol is a beta-2 receptor agonist that can increase fluid removal and speed the return of effective oxygen exchange. This study aims to evaluate the safety and efficacy of nebulized albuterol as an adjuvant therapy in patients with acute anticholinesterase poisoning. This stratified block randomized, single-blinded, placebo-controlled, parallel-group clinical trial was conducted between November 2020 and October 2021. It enrolled 80 patients with acute anticholinesterase pesticide poisoning who were admitted to Tanta University Poison Control Center. Patients were allocated into two groups (40 patients each). The strata were based on the severity of poisoning (moderate and severe). Patients in group I received 10 mg of nebulized albuterol. Group II received an equivalent volume of nebulized normal saline. Additionally, standard treatment was provided to both groups. Outcomes included oxygenation, mortality, need for endotracheal intubation and mechanical ventilation, hospital stay duration, time to atropinization, and total doses of atropine and oxime. We found insignificant differences in sociodemographics, exposure characteristics, clinical manifestations, or routine laboratory tests between the studied groups. The median values of oxygen saturation by pulse oximetry were 99% in the albuterol moderate toxicity group and 98% in the control moderate toxicity group. Albuterol significantly improved oxygen saturation in moderate intoxicated patients (P = 0.039). Therefore, nebulized albuterol is a safe drug. Moreover, it may improve oxygenation in acute anticholinesterase pesticide poisoning.

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Frequency of Organophosphate Poisoning and its Outcome in SKBZ AK CMH Muzaffarabad

Cited by 2 publications

References 13 publications

Severe acute organophosphate poisoning managed with 2-month prolonged atropine therapy: a case report

Severe acute organophosphate poisoning managed with 2-month prolonged atropine therapy: a case report

Albuterol as an adjuvant in acute anticholinesterase pesticide poisoning: a randomized, placebo-controlled clinical trial

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