Frequency of portal and systemic bacteremia in acute appendicitis

Jurić, Ivo; Primorac, Dragan; Zagar, Z; Biocic, Mihovil; Pavić, Siniša; Furlan, Dubravko; Budimir, Dražen; Janković, Stipan; Hodzic, Petar Kresimir; Alfirević, Darko; Alujević, Antonio; Titlić, Marina

doi:10.1046/j.1442-200x.2001.01360.x

Cited by 30 publications

(24 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These inflammatory agents may also alter the hepatic blood flow and normal physiological flow of the bile causing hyperbilirubinemia. [3][4][5][6][7][8] Few other studies have compared various inflammatory agents with total bilirubin as a predictive marker of perforation of appendix.…”

mentioning

confidence: 99%

Role of serum bilirubin as a marker of acute gangrenous appendicitis

2012

View full text Add to dashboard Cite

Background: This study has compared the difference in serum bilirubin between patients with gangrenous and non-gangrenous appendicitis. Methods: A prospective analytical study of, 141 patients who underwent appendectomy, from March 2010 to March 2011 in Manipal Teaching Hospital, Pokhara, Nepal was carried out. Clinico-demographic data, Alvarado’s score, total serum bilirubin, total leucocyte count and histopathological report of all the cases were collected in a prestructured proforma. Comparison between gangrenous and non-gangrenous appendicitis groups was carried out using independent sample t test, Chisquare test, and direct logistic regression. The data was analyzed using SPSS 11.6 software. Result: Around 43% (61 out of 141) patients had gangrenous appendicitis and statistically significant difference was found between the two groups in total Alvarado’s score, total count and total bilirubin level. The effect size as indicated by eta square statistics was large for total bilirubin (eta squared=0.39) as compared to total Alvarado’s score (0.09) and total leucocyte count (0.05). Direct logistic regression model showed serum total bilirubin as the only independent variable to make a unique statistically significant contribution in predicting gangrenous appendicitis. Conclusion: Pre-operative assessment of serum total bilirubin can serve as an important maker of acute gangrenous appendicitis. DOI: http://dx.doi.org/10.3126/njms.v1i2.6606 Nepal Journal of Medical Sciences. 2012;1(2): 89-92

show abstract

mentioning

confidence: 99%

Role of serum bilirubin as a marker of acute gangrenous appendicitis

2012

View full text Add to dashboard Cite

show abstract

“…The rate of blood culture positivity in acute appendicitis is actually low. A prospective study revealed that systemic bacteraemia was 0% at 30 min before surgery and 6% during surgery 6. Furthermore, blood cultures became positive in only 10% of cases of acute appendicitis with perforation, and an extremely low percentage in appendicitis without perforation 7.…”

Section: Discussionmentioning

confidence: 99%

Hidden diagnosis behind viral infection: the danger of anchoring bias

et al. 2018

View full text Add to dashboard Cite

Anchoring bias is one of the most common diagnostic biases that may lead to closed-minded thinking and could result in unnecessary tests, inappropriate patient management and even misdiagnosis. A 4-year-old boy was brought to the emergency department because of shaking chills. On the basis of bilateral swollen preauricular areas, high level of serum amylase and the prevalence of mumps, he initially received a diagnosis of mumps in spite of the shaking chills. However, blood culture turned out to be positive for two different kinds of bacteria. The patient finally received a diagnosis of polymicrobial bacteraemia resulting from suppurative appendicitis. We must consider and rule out bacteraemia in the differential diagnosis for patients who present with shaking chills, even in the presence of symptoms or information consistent with a more common viral infection such as mumps. In addition, intra-abdominal infection should be ruled out in the presence of polymicrobial enterobacteriaceae bacteraemia.

show abstract

“…It is also known that in appendicitis, bacteria can traverse the intact appendiceal wall prior to perforation and the number of bacteria that do this, increase when there is more inflammation and tissue damage present [6]. There is a high rate of portal bacteraemia (45%) seen in patients with confirmed appendicitis but due to the liver being an effective barrier in preventing bacteria entering the systemic circulation, only 7% have systemic bacteraemia [7].…”

Section: Discussionmentioning

confidence: 99%

Pseudomonas aeruginosa bacteraemia in an adult with cystic fibrosis and acute appendicitis

Gilchrist¹,

Doherty

Govan

et al. 2011

Journal of Cystic Fibrosis

View full text Add to dashboard Cite

Despite their high bacterial load, bacteraemia is rare in patients with cystic fibrosis (CF). We report an adult with CF who developed Pseudomonas aeruginosa bacteraemia during an episode of acute appendicitis. The Pseudomonas aeruginosa isolated from the blood culture was confirmed by molecular typing to be the same transmissible strain responsible for the patient's chronic pulmonary infection. We hypothesise that this patient's bacteraemia was caused by Pseudomonas aerunginosa in swallowed sputum, crossing the inflamed appendiceal wall and entering the blood stream.

show abstract

Frequency of portal and systemic bacteremia in acute appendicitis

Cited by 30 publications

References 7 publications

Role of serum bilirubin as a marker of acute gangrenous appendicitis

Role of serum bilirubin as a marker of acute gangrenous appendicitis

Hidden diagnosis behind viral infection: the danger of anchoring bias

Pseudomonas aeruginosa bacteraemia in an adult with cystic fibrosis and acute appendicitis

Contact Info

Product

Resources

About