Frequency of Recipient-Derived Chimerism and Relationship With Acute Rejection and HLA Tissue Typing in Transplanted Livers

Bilezikçi, Banu; Şahin, Feride İffet; Uyar, P.; Yılmaz, Zerrin; Demirhan, Beyhan; Turan, M; Arat, Z.; Haberal, Mehmet

doi:10.1016/j.transproceed.2005.12.059

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…24 In liver allograft parenchyma, cells of recipient origin cannot always be considered functional, in that they may show inflammatory cell profile. 26 This finding has been confirmed by Bilezikçi et al, 58 who found no significant association between RC and clinicopathological outcomes.…”

Section: Discussionmentioning

confidence: 57%

Effect of Reverse Chimerism on Rejection in Clinical Transplantation

Bolado

Landín

2013

Annals of Plastic Surgery

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Chimerism may enable allografts to survive when immunosuppressive therapy is administered at low levels or is even absent. Reverse chimerism (RC) is focused on intragraft chimerism that repopulates the allograft with cells of recipient origin. We aimed to identify and analyze current clinical evidence on RC and the presence of endothelial RC and tissue-specific RC. A total of 33 clinical reports on cardiac, kidney, liver, and lung transplants published between 1972 and 2012 that focused on RC were included in a systematic review. Liver allografts presented with the highest percentage of endothelial RC and lung allografts by far the lowest. Tissue-specific RC was present in most of the recipients, but at very low levels. There were also cardiac and kidney allografts with chimerism, but the functionality of the cells of recipient origin was questionable. We were unable to determine whether RC was a trigger for or a result of acute rejection. Further clinical research should focus on outcomes to evaluate the clinical relevance of this form of chimerism in transplantation.

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Section: Discussionmentioning

confidence: 57%

Effect of Reverse Chimerism on Rejection in Clinical Transplantation

Bolado

Landín

2013

Annals of Plastic Surgery

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Prospective analysis between the therapy of immunosuppressive medication and allogeneic microchimerism after liver transplantation

Araújo

Leonardi

et al. 2009

Transplant Immunology

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Bladder Wall Transplantation—Long-Term Survival of Cells: Implications for Bioengineering and Clinical Application

Tanaka

Thangappan

Eandi

et al. 2010

Tissue Engineering Part A

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Current bioengineered bladder wall substitutes include acellular scaffolds and grafts seeded with autologous cells. The transplanted cells on a seeded graft may regenerate and/or be replaced by cells of the patient's bladder. This may or may not be advantageous depending upon the underlying pathology. A theoretically perfect bioengineered graft would be intact bladder wall. To determine if such a graft is feasible and to study the cellular changes, we transplanted full-thickness bladder grafts from male inbred rats onto bladders of female syngeneic rats. Bladders were harvested at 1, 3, 6, 12, and 16 months after surgery and evaluated for histologic changes. Cell origin (male donor vs. female host) was determined with fluorescent in situ hybridization with unique probes for rat X and Y chromosomes. Urothelial hyperplasia, inflammation, and increased stromal thickness subsided down to control values by 6 months after surgery. At 16 months, graft muscle demonstrated persistence of male cells. On the other hand, graft urothelium was partially replaced by female host cells with a pattern suggestive of a hematogenous route rather than ingrowth from the host bladder. Bladder wall transplantation is feasible. The slow replacement of the transplanted urothelium and persistence of muscle may imply the same fate for engineered grafts.

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Frequency of Recipient-Derived Chimerism and Relationship With Acute Rejection and HLA Tissue Typing in Transplanted Livers

Cited by 4 publications

References 13 publications

Effect of Reverse Chimerism on Rejection in Clinical Transplantation

Effect of Reverse Chimerism on Rejection in Clinical Transplantation

Prospective analysis between the therapy of immunosuppressive medication and allogeneic microchimerism after liver transplantation

Bladder Wall Transplantation—Long-Term Survival of Cells: Implications for Bioengineering and Clinical Application

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