Frequency of recurrent spontaneous abortion and its influence on further marital relationship and illness: The Okazaki Cohort Study in Japan

Takahashi

Reprod Medicine & Biology

et al. 2019

Purpose Inversion of chromosome 9 (inv[9]) is considered to be a normal variant, and the inv(9) in patients or husbands with recurrent pregnancy loss (RPL) is believed to be harmless. However, there are few reports concerning the outcomes of pregnancy in patients with RPL when the patient or their partner has inv(9). In this study, we analyzed the outcomes of pregnancy in this patient population. Methods Chromosomal karyotyping was performed for 2006 couples with RPL (two or more consecutive early pregnancy losses including non‐visualized cases) with their informed consent. The frequency of various chromosomal abnormalities in the patient population was then analyzed, and the outcomes of pregnancy in patients with inv(9) were investigated. Results The frequency of inv(9) in the overall population was 2.6% (52/2006). Thus far, 32 patients have conceived repetitively, resulting in live births in 23 cases and early pregnancy losses in nine cases. Four of the nine cases obtained a good outcome in the subsequent pregnancy. Thus, a successful outcome was obtained in 27 of the 32 (84.4%) cases. Conclusions This study suggests that inv(9) has no adverse influence on subsequent pregnancy.

Section: Discussionmentioning

confidence: 91%

The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)

Takahashi

Reprod Medicine & Biology

et al. 2019

J of Obstet and Gynaecol

“…However, many researchers have now revised the definition to two or more pregnancy losses, because of the recent increase in the prevalence of childless couples. The estimated frequencies of three or more and two or more consecutive pregnancy losses are 0.9% and 4.2%, respectively, in the Japanese general population . For the present review, RM is defined as two or more consecutive pregnancy losses.…”

Section: Causes Of Recurrent Miscarriagementioning

confidence: 99%

“…The estimated frequencies of three or more and two or more consecutive pregnancy losses are 0.9% and 4.2%, respectively, in the Japanese general population. 1 For the present review, RM is defined as two or more consecutive pregnancy losses.…”

Section: Causes Of Recurrent Miscarriagementioning

confidence: 99%

Management of recurrent miscarriage

Sugiura‐Ogasawara

Ozaki

Suzumori

2014

Self Cite

Recurrent miscarriage is classically defined as three or more consecutive pregnancy losses. Many researchers have now revised this definition to two or more pregnancy losses because of the recent increase in the prevalence of childless couples. Established causes of recurrent miscarriage are antiphospholipid antibodies, uterine anomalies and abnormal chromosomes in either partner, particularly translocations. Antiphospholipid syndrome is the most important treatable cause of recurrent miscarriage. However, it is not yet established as to what kind of testing should be conducted in patients with recurrent pregnancy loss. Standardization of tests for antiphospholipid antibodies is needed. On the other hand, embryonic aneuploidy is the most frequent cause of recurrent miscarriage. Chromosome analysis of the embryo is important, because it has good predictive value for subsequent live birth. It is not necessary to give any medications for unexplained cases of recurrent miscarriage, and provision of psychological support may be the most important to encourage the couples to continue to conceive until a live birth results.

J of Obstet and Gynaecol

“…Pregnancy loss is among the most common obstetric complications and affects up to 15% of pregnancies. Recurrent pregnancy loss affects 4.2% of pregnancies and results in high medical, emotional, social and economic burdens . Despite its frequency and significant impact on individuals and society, reliable screening markers for risk of pregnancy loss remain insufficient.…”

Section: Introductionmentioning

confidence: 99%

Impact of maternal methylenetetrahydrofolate reductase C677T polymorphism on intervillous and decidual pathology with pregnancy loss

Mehandjiev

Tenno

Nakura

et al. 2018

To our knowledge, this is the first study showing that the MTHFR C677T TT genotype and T allele are associated with severe intervillous and decidual pathologies in patients with pregnancy loss. Differences in pathologic grades of MTHFR C677T TT genotype could support the hypothesis that further periconceptional treatment for pregnancy loss could be customized depending on single nucleotide polymorphisms.