Frequency of Red Cell Alloantibodies in Pregnant Females of Navsari District: An Experience that Favours Inclusion of Screening for Irregular Erythrocyte Antibody in Routine Antenatal Testing Profile

Kahar, Manoj A

doi:10.1007/s13224-017-0984-5

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…The distribution of maternal alloimmunization varies in different populations in different countries. The alloimmunization rate in this study was 9.8%, with that among the D − participants being 24.4%, which is much higher than reported by Das et al 4 (2.27%), Sahoo et al 12 (3.6%), and Kahar 13 (1.02%) in studies conducted in India and Europe, where the prevalence was in the range of 0.5-2.57%. The higher rate of alloimmunization in this study could be due to the variations in the population ethnicity.…”

Section: Discussioncontrasting

confidence: 66%

Alloimmunization to Rh Antigen (D, C, E, C, E) Among Pregnant Women Attending Antenatal Care in South Western Uganda

Mbalibulha¹,

Natukunda²,

Okwi³

et al. 2022

JBM

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Introduction Maternal red cell alloimmunization to Rh antigen in pregnant women occurs when the immune system is sensitized by foreign red blood cell surface antigens, in this case fetal red blood cells, inducing an immune response. Various antigens of blood group systems may cause alloimmunization, especially the Rh, Kel, Fy, JK, and MNS systems. This study aimed to determine alloimmunization to the different frequencies of Rh antigen among pregnant women in South Western Uganda. Methods A total of 1369 pregnant women consented and were recruited into a cross-sectional study during their regular antenatal visits during the period August 2020 to July 2021. Samples (4 mL) of anticoagulated and coagulated blood were obtained, and Rh blood grouping including Rh antigen and the indirect antiglobulin test (IAT) was carried out using the agglutination technology of the LISS ID-Card technique in the Ortho Biovue ID-Micro Typing System. Results Out of 1369 participants recruited to the study, 78 (5.7%) were D − , 1291 were D + , and 134 (9.8%) had alloantibodies. Among those with alloantibodies, 115 (85.8%) were D + and 19 (14.2%) D − . The percentage alloimmunization according to the Rh antigens was highest in e (9.72%), c (2.48%), C (2.34%) and E (0.94%) antigens. With the ABO system, alloimmunization was highest in blood group B (10.7%), followed by A (10.6%), O (9.2%) and then AB (7.1%). Alloimmunization was more prevalent in D − (24%) than in D + participants (8.9%). Rhesus antigen e was the most prevalent antigen (99.8%), followed by c. The alloimmunization rate of 9.8% among these participants is high, and appears in both D + and D − women. The other Rhesus antigens are seen to cause alloimmunization, with antigen e causing the highest prevalence. In conclusion, there is a need to identify antibodies and study the outcome for clinical significance, especially in D + women, to facilitate proper pregnancy management.

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Section: Discussioncontrasting

confidence: 66%

Alloimmunization to Rh Antigen (D, C, E, C, E) Among Pregnant Women Attending Antenatal Care in South Western Uganda

Mbalibulha¹,

Natukunda²,

Okwi³

et al. 2022

JBM

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“…The largest number of cases was associated with anti-D with a frequency of 86.4%, as evidenced by the eluate test, which is justified by the fact that the D antigen is highly immunogenic, and it is the most associated to triggering the disease 3 . Scientifical studies confirm that anti-D is still the most frequent and is the main cause of HDN, being responsible for 80% to 90% of cases 5,6 .…”

Section: Discussionmentioning

confidence: 98%

Frequency of red blood cells antibodies in possible cases of hemolytic disease of the newborn laboratory evidenced at Hemopa

Coutinho,

Carvalho,

Carvalho

et al. 2022

Pará Research Medical Journal

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Purpose: To describe the frequency of red blood cells antibodies possibly related to Hemolytic Disease of the Newborn cases reported laboratory evidenced at Fundação Centro de Hemoterapia e Hematologia do Pará. Methods: This is a descriptive, cross-sectional study, based on the analysis of immuno-hematological reports of newborns filed at the Immunohematology Laboratory of the Fundação Centro de Hemoterapia e Hematologia do Pará , released between January 2015 and December 2019. The obtained data are related to ABO/Rh(D) typing; Direct Antiglobulin test; Irregular Antibodies test; Eluate, which were transcribed to Microsoft Excel sheets for later descriptive analysis. The study was approved by the Research Ethics Committee of the Fundação Pública Estadual do Hospital das Clínicas Gaspar Vianna, under the legal opinion #3,435,869. Results: A total of 37 reports were analyzed, laboratory evidence showed 34 cases of positive Direct Antiglobulin Test, of these, 22 presented positive eluate test. The highest frequency of described cases was related to anti-D antibody (19/22; 86.4%), followed by anti-c (1/22; 4.5%) and clinically significant antibody associations (2/22; 9.1%). Conclusion: The most frequent alloantibody evidenced was anti-D, however, other red blood cells alloantibodies observed drew attention and were considered relevant scientific evidence regarding the subject.

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“…Findings from this study showed that the prevalence of Rh alloimmunization was 17.1%. Results from this study were relatively higher than those from studies conducted in Jimma (14.3%) ( 31 ), western Uganda (3.6%), South Western Uganda (3.9%), and Western Uganda (5.7%) ( 22 , 32 – 34 ), respectively; a systematic review conducted in sub-Saharan Africa (6.7%) ( 32 ), India (4.2%), (6.9%), (10.4%) ( 22 , 33 , 34 ), respectively; and USA (0.74%) ( 35 ). The possible justifications include the use of advanced diagnosis and early booking of ANC, sample size, and socioeconomic characteristics of study participants.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and determinants of RH alloimmunization in Rh-negative women in teaching hospitals of Addis Ababa, Ethiopia: a hospital-based cross-sectional study

Maruta,

Tesfaye,

Birhanu

et al. 2023

Front. Glob. Womens Health

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BackgroundDespite the implementation of immunization with an anti-D antigen for pregnant women, adverse pregnancy outcomes continue to occur in Ethiopia and most Sub-Saharan African countries. Consequently, the woman's obstetric care is compromised, and there is an increase in perinatal morbidity and mortality. In Ethiopia, the burden of the disease is not well understood, and no research has been conducted in the study area. Therefore, this study aims to determine the prevalence and determinants of Rh alloimmunization in Rh-negative women receiving care at Addis Ababa teaching hospitals.MethodsAn institutional-based cross-sectional study was conducted from 5 October 2020 to 5 May 2021, among 328 Rh-negative pregnant women who received antenatal care and delivery services at Teaching Hospitals under Addis Ababa University. Face-to-face interviews were used to gather data using a pre-tested structured questionnaire, and a chart review was performed using a checklist. The data were entered into Epidata version 3.1 and analyzed using SPSS version 22. Multivariable analysis and logistic regression were used to evaluate the predictors, and the results were presented as an adjusted odds ratio (AOR) with a 95% confidence interval. Statistical significance was declared at a p-value < 0.05.ResultsAmong Rh-D negative individuals, 56(17.1%) were alloimunized with 95% CI (15.1%, 19.23%). The prevalence of Rh-D negative was 2.1% with 95% CI (1.56%, 2.76%). Factors such as unemployment [AOR = 2.28, 95% CI: 1.21, 4.28], failure to use anti-D prophylaxis in previous pregnancy [AOR = 2.08, 95% CI: 1.10, 3.92), and the presence of sensitizing events [AOR = 0.52, 95% CI: 0.27, 0.84] were statistically significant with the outcome variables.ConclusionsThis study pointed out that the prevalence of Rh was relatively large and that almost one in every five pregnant women was alloimunized. Factors such as unemployment and failure to use anti-D prophylaxis in a previous pregnancy were found to be associated with outcome variables. Therefore, all stakeholders and concerned entities should prioritize enhancing access and affordability to anti-D prophylaxis to prevent the occurrence of Rh alloimmunization and its associated adverse outcomes.

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Frequency of Red Cell Alloantibodies in Pregnant Females of Navsari District: An Experience that Favours Inclusion of Screening for Irregular Erythrocyte Antibody in Routine Antenatal Testing Profile

Cited by 10 publications

References 21 publications

Alloimmunization to Rh Antigen (D, C, E, C, E) Among Pregnant Women Attending Antenatal Care in South Western Uganda

Alloimmunization to Rh Antigen (D, C, E, C, E) Among Pregnant Women Attending Antenatal Care in South Western Uganda

Frequency of red blood cells antibodies in possible cases of hemolytic disease of the newborn laboratory evidenced at Hemopa

Prevalence and determinants of RH alloimmunization in Rh-negative women in teaching hospitals of Addis Ababa, Ethiopia: a hospital-based cross-sectional study

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