Frequency of seafood intake in pregnancy as a determinant of birth weight: evidence for a dose dependent relationship.

Olsen, S F; Grandjean, Philippe; Weihe, Pál; Viderø, T

doi:10.1136/jech.47.6.436

Cited by 112 publications

(94 citation statements)

References 7 publications

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“…The Excess condition in our rats did not have significant effects on birth weights, gestational length or other birthing variables; whereas several human studies showed such effects in infants born to women who consumed the highest amounts of seafood [17][18]30,[32][33]38,45]. Thus, our Excess condition in the rat was less toxic than the high dose condition in humans.…”

Section: Comments On Dosingcontrasting

confidence: 57%

Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother

Church

Jen

Stafferton

et al. 2007

Neurotoxicology and Teratology

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Consumption of the nutrients omega-3 fatty acids (ω-3 FA) during pregnancy and lactation is considered beneficial to fetal and infant development. It may also reduce the incidence and severity of preterm births by prolonging gestational length. However several recent human and animal studies have reported that over-supplementation with ω-3 FA, especially in the form of fish oil, can have adverse effects on fetal and infant development and the auditory brainstem response (ABR). Our goal was to assess further the effects of ω-3 FA excess and deficiency during pregnancy and lactation on the offspring's auditory acuity as evidenced by their ABR thresholds. Female Wistar rats were given diets that were either deficient, adequate (control) or excess in ω-3 FA from day 1 of pregnancy through lactation. The offspring were ABR-tested at the postnatal age of 24 days. The rat pups in the Excess treatment condition had significantly elevated (worse) ABR thresholds, postnatal growth restriction, and a trend for increased postnatal mortality in comparison to the Control group. The Deficient group was intermediate. In conclusion, excess or deficient amounts of ω-3 FA during pregnancy and lactation in the laboratory rat adversely affected the offspring's auditory acuity. Postnatal thriving was also adversely affected. Consuming or administering large or inadequate amounts of ω-3 FA during pregnancy and lactation seems inadvisable because of the potential for adverse effects on infant development.

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Section: Comments On Dosingcontrasting

confidence: 57%

Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother

Church

Jen

Stafferton

et al. 2007

Neurotoxicology and Teratology

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“…The prevalence of small for gestational age (SGA) in the Norwegian Mother and Child Cohort Study (MoBa) is 6?6 % and the prevalence of low birth weight (,2500 g) is about 4?6 % in the MoBa cohort and 0?7 % in children born at term (.37 weeks of gestation) (19,20) . Positive associations between seafood consumption during pregnancy, and in particular lean seafood, and birth weight and SGA have been found in several studies, including the present cohort, while a few studies report inverse associations (21,22) . These inverse associations are often connected to the presence of environmental toxicants like polychlorinated biphenyls (PCB) and Hg (23,24) .…”

mentioning

confidence: 85%

Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study

Vejrup

Brantsæter

Knutsen

et al. 2013

Public Health Nutr.

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Objective: To examine the association between calculated maternal dietary exposure to Hg in pregnancy and infant birth weight in the Norwegian Mother and Child Cohort Study (MoBa). Design: Exposure was calculated with use of a constructed database of Hg in food items and reported dietary intake during pregnancy. Multivariable regression models were used to explore the association between maternal Hg exposure and infant birth weight, and to model associations with small-for-gestational-age offspring. Setting: The study is based on data from MoBa. Subjects: The study sample consisted of 62 941 women who answered a validated FFQ which covered the habitual diet during the first five months of pregnancy. Results: Median exposure to Hg was 0?15 mg/kg body weight per week and the contribution from seafood intake was 88 % of total Hg exposure. Women in the highest quintile compared with the lowest quintile of Hg exposure delivered offspring with 34 g lower birth weight (95 % CI 246 g, 222 g) and had an increased risk of giving birth to small-for-gestational-age offspring, adjusted OR 5 1?19 (95 % CI 1?08, 1?30). Although seafood intake was positively associated with increased birth weight, stratified analyses showed negative associations between Hg exposure and birth weight within strata of seafood intake. Conclusions: Although seafood intake in pregnancy is positively associated with birth weight, Hg exposure is negatively associated with birth weight. Seafood consumption during pregnancy should not be avoided, but clarification is needed to identify at what level of Hg exposure this risk might exceed the benefits of seafood.

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“…This finding indicates that the difference determined for heavy smokers in the east-and westcoast cohorts originated not only from a long median time to pregnancy for heavy-smoking women in the eastcoast cohort, but also from a relatively short median time to pregnancy for heavy-smoking women from the westcoast cohort. Several studies have found a positive correlation between the consumption of noncontaminated fish during pregnancy on one hand and birthweight and duration of pregnancy on the other (27,28), but other reproductive outcomes have not been investigated. Thus whether a high intake of noncontaminated fatty fish is a positive factor for fertility can only be a matter of speculation.…”

Section: Discussionmentioning

confidence: 99%

Time to pregnancy and infertility among women with a high intake of fish contaminated with persistent organochlorine compounds

Axmon¹,

Rylander²,

Strömberg³

et al. 2000

Scand J Work Environ Health

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Time to pregnancy and infertility among women with a high intake of fish contaminated with persistent organochlorine compounds by Axmon A, Rylander L, Strömberg U, Hagmar LThe following article refers to this text: 2002;28(2):0 Key terms: contamination; fertility; fish; infertility; PCP; persistent organochlorine compound; polychlorinated biphenyl; polychlorinated dibenzo-p-dioxin; polychlorinated dibenzofuran; time to pregnancy; woman This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/10901111 Scand J Work Environ Health 2000;26(3): 199-206 Time to pregnancy and infertility among women with a high intake of fish contaminated with persistent organochlorine compounds by Anna Axmon, MSc,' Lars Rylander, DrMedSc,' Ulf Stromberg, PhD,' Lars Hagmar, MD1 Axmon A, Rylander L, Stromberg U, Hagmar L. Time to pregnancy and infertility among women with a high intake of fish contaminated with persistent organochlorine compounds. Scand J Work Environ Health 2000;26(3):199-206. Objectives The purpose of this study was to assess the effect of persistent organochlorine compounds through the dietary intake of fatty fish from the Baltic Sea on human fertility. Methods Information on time to pregnancy, subfertility, and infertility was collected retrospectively by selfadministered questionnaires in 2 cohorts of fishermen's wives from the Swedish east (by the Baltic Sea) and west coasts. In addition to cohort affiliation, current fish consumption and growing up in a fishing village were used as proxies for exposure within the eastcoast cohort. Results A decreased success (ie, pregnancy) rate and a tendency towards increased subfertility was found for heavy smokers (210 cigaretteslday) in the eastcoast cohort as compared with the westcoast cohort [success rate ratio 0.66, 95% confidence interval (95% CI) 0.49-0.89; subfertility odds ratio 1.64, 95% CI 0.91-2.91). However, internal analyses within the eastcoast cohort did not show that growing up in a fishing village or high current fish consumption decreased the success rate. Eastcoast cohort affiliation showed an increased risk for infertility (odds ratio 2.49,95% CI 1.05-5.92). C O~C~U S~O~S The present data give some support for a negative association between exposure to persistent organochlorine compounds and fertility among heavy smokers. However, when the proxy exposure measures are also considered, the findings are not consistent. Better individual exposure assessments should be used before more firm conclusions are drawn.Key terms fertility, polychlorinated biphenyls, polychlorinated dibenzofurans, polychlorinated dibenzo-pdioxins.For the general Swedish population, the consumption of fatty fish from the Baltic Sea is an important source of exposure to persistent organochlorine compounds such as polychlorinated biphenyls (PCB) and dioxins (1, 2). Eastcoast fishermen and their wives have been a relatively highly exposed group; they have reported doubled fish consumption on an average when compared with the general population ( 2 4 ) . Among these fishermen, higher b...

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Frequency of seafood intake in pregnancy as a determinant of birth weight: evidence for a dose dependent relationship.

Cited by 112 publications

References 7 publications

Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother

Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother

Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study

Time to pregnancy and infertility among women with a high intake of fish contaminated with persistent organochlorine compounds

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