Frequency of the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene in patients with migraine with or without aura – a preliminary report

Szczygioł, Dorota; Motta, Ewa; Gołba, Anna; Stęposz, Arkadiusz; Witecka, Joanna; Dębski, Maciej; Błaszkiewicz, Daria; Sieroń, Aleksander

doi:10.5114/ninp.2012.31354

Cited by 10 publications

(6 citation statements)

References 25 publications

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“…8 Many attempts have been made to investigate concentrations of Hcy, as a well-known predictor for cardiovascular disorders, in patients suffering from migraine. 57 Our results seem to agree with a more recently published study in which it has been observed that women who suffer from migraine with T allele of MTHFR gene had significantly higher concentration of Hcy and lesser B12 (309.03 vs 314.36 pmol/L) and B9 levels in their serum samples in comparison with carriers of CC genotype. This hypothesis appeared to be substantiated by findings that found higher concentrations of Hcy in cerebrospinal fluid (CSF) of migraine suffers than controls.…”

Section: Discussionsupporting

confidence: 93%

“…56 A recent study by Szczygioł et al, who evaluated the frequency of C677T variant of MTHFR gene, and Hcy concentrations of 91 migraineurs, showed significantly higher proportion of hyperhomocysteinemia in patients with C677T variant than the others. 57 Our results seem to agree with a more recently published study in which it has been observed that women who suffer from migraine with T allele of MTHFR gene had significantly higher concentration of Hcy and lesser B12 (309.03 vs 314.36 pmol/L) and B9 levels in their serum samples in comparison with carriers of CC genotype. 58 However, due to the very low proportion of patients with aura in the current study we failed to explore vitamin B12 and MMA status in those with and without aura compared to controls.…”

Section: Discussionsupporting

confidence: 93%

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Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case‐Control Study

et al. 2019

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Background Although the exact pathophysiological mechanistic pathways that result in the initiation of migraine attacks remain unclear, there are some proposed mechanisms including neurogenic inflammation, trigeminovascular system activation, vascular dysfunction, and augmented release of nitric oxide (NO) and homocysteine (Hcy). Vitamin B12 is thought to be involved in important pathways that seem to be related to the pathogenesis of migraine including scavenging against NO and prevention of hyperhomocysteinemia. Therefore, the aim of the current study was to evaluate the serum vitamin B12 and methylmalonic acid (MMA) status in a group of migraine patients compared to healthy controls. Methods After the recruitment of cases and controls, demographic data and migraine characteristics (including the number of headache days, severity of headaches, and duration of each attack in hours) were recorded. Serum vitamin B12 and MMA levels were measured using the enzyme‐linked immunosorbent assay technique. Results Seventy migraine patients and 70 healthy subjects were enrolled in this case control study. The serum levels of B12 were found to be significantly lower in migraine patients than in healthy subjects (512 ± 300 vs 667 ± 351 pg/mL, P = .007); whereas migraineurs had higher levels of MMA than controls (1.39 [0.59,4.01] vs 1.01 [0.49,1.45] µg/dL, P = .027). In the fully adjusted multiple regression model, those in the highest vs the lowest serum B12 quartile had 80% decrease in the odds of having migraine ([OR = 0.20, 95% CI = 0.05‐0.73], [P for trend = .008]); while, patients in the highest quartile of MMA had more than 5 times increased risk of having migraine ([OR = 5.44, 95% CI = 1.49‐19.87] [P for trend = .002]). There was no association between serum B12 and MMA levels and headache characteristics. Conclusion Taken together, these findings suggest that participants with lower vitamin B12 and higher MMA levels that considered as lower functional activity of B12 had higher odds of migraine.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case‐Control Study

et al. 2019

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“…Among the excluded studies, 1 study compared TTH patients with HC, 82 1 study compared a group of MA patients with a group of MO plus TTH patients (figures for MO alone were not provided), 83 1 study compared a migraine group (figures for MA and MO were not provided separately), with a HC group and group of TTH patients, but relevant figures were not provided for the HC group, 84 1 study provided relevant figures for PHD patients and patients with cerebral venous sinus thrombosis (figures for MA and MO were not provided separately), 85 4 studies did not provide homocysteine levels according to the subtype of migraine (figures were presented according to the presence or not of white matter lesions, 86,87 according to sex and anthropometric measurements, 88 according to genetic parameters 89 ), 5 studies were uncontrolled (either only patients with MA or only patients with MO were included, absence of a HC group), 90‐94 2 studies (evaluating the same group of patients) determined the presence of hyperhomocysteinemia in patients with MA and MO (comparative statistics and Hcy levels were not available), 95,96 1 study assessed the presence of hyperhomocysteinemia according to genetic parameters, 97 1 study did not present any relevant figures or statistical comparisons between MA and MO patients, 98 4 studies evaluated the presence of migraine according to not‐validated diagnostic criteria (according to self‐reported presence of migraine headache 99‐101 and severe headache 102 ), 2 studies were case series, 103,104 and 4 studies did not provide relevant information 105‐108 …”

Section: Resultsmentioning

confidence: 99%

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

et al. 2020

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Background Migraine, especially migraine with aura (MA), has been linked to increased risk for ischemic cerebrovascular disease. The possible role of elevated serum homocysteine (Hcy, a cause of thrombophilia) in migraine has been demonstrated by several studies. Objective The present study aims to review and meta‐analyze data from studies investigating the difference of serum Hcy and Hcy lowering vitamins between migraine patients and healthy controls (HC), as well as between patients with MA and migraine without aura (MO). Methods Literature search involved MEDLINE, Embase, CENTRAL, Google Scholar, and trial registries. The Newcastle‐Ottawa Scale was used to evaluate the quality of the retrieved studies. Standardized mean differences (SMDs) and 95% confidence intervals (95%CIs) were calculated. Funnel‐plots were utilized for the evaluation of publication bias. Results Overall, 29 (28 case‐control and 1 cross‐sectional) studies were retrieved. Meta‐analysis was indicative of higher Hcy concentration in migraine patients vs HC overall [adults and children: 16 studies, I2 = 81%, SMD = 0.41, 95%CI = (0.20, 0.61)]. Hcy was consistently elevated in adults with migraine [adults: 12 studies, I2 = 76%, SMD = 0.35, 95%CI = (0.15, 0.54); children: 1 study, SMD = 0.37, 95%CI = (−0.05, 0.79)]. Subgroup analyses reproduced the results for both adults with MA [7 studies, I2 = 83%, SMD = 0.37, 95%CI = (0.03, 0.71)] and MO [5 studies, I2 = 84%, SMD = 0.46, 95%CI = (0.03, 0.89)]. Figures for serum folate were lower in the overall comparison of migraine patients with HC [adults and children: 11 studies, I2 = 87%, SMD = −0.36, 95%CI = (−0.68, −0.05); adults: 8 studies, I2 = 6%, SMD = −0.11, 95%CI = (−0.22, 0.01); children: 1 study, SMD = −0.71, 95%CI = (−1.14, −0.29); MA adults: 4 studies, I2 = 44%, SMD = −0.16, 95%CI = (−0.35, 0.04); MO adults: 4 studies, I2 = 47%, SMD = −0.17, 95%CI = (−0.44, 0.10)]. Serum vitamin B12 levels were not different between migraine patients and HC [adults and children: 11 studies, I2 = 88%, SMD = −0.24, 95%CI = (−0.57, 0.09); adults: 8 studies, I2 = 57%, SMD = −0.10, 95%CI = (−0.28, 0.08); children: 1 study, SMD = 0.29, 95%CI = (−0.13, 0.71); MA adults: 4 studies, I2 = 63%, SMD = −0.14, 95%CI = (−0.48, 0.20); MO adults: 4 studies, I2 = 59%, SMD = −0.15, 95%CI = (−0.45, 0.15)]. Serum Hcy was lower in MO than MA [adults and children: 10 studies, I2 = 39%, SMD = 0.30, 95%CI = (0.14, 0.46), adults: 6 studies, I2 = 29%, SMD = 0.21, 95%CI = (0.09, 0.36), children: 1 study, SMD = 0.51, 95%CI = (0.22, 0.80)]. Serum folate and vitamin B12 did not differ between MA and MO. Conclusions Our results suggest that there is a possible link between migraine, mainly MA, and elevated serum Hcy.

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“…Stwierdza siê tak¿e wystêpowanie wariantu C677T genu MTHFR (gen reduktazy metylotetrahydrofolianu), który jest kojarzony ze zwiêkszonym stê¿eniem we krwi homocysteiny, bêd¹cej potencjalnym czynnikiem ryzyka pojawienia siê migreny. Homozygoty wariantu C677T genu MTHFR wystêpo-wa³y natomiast czêoeciej u chorych na migrenê z aur¹ i dro¿nym otworem owalnym, bêd¹cym kolejnym przypuszczalnym czynnikiem przyczyniaj¹cym siê do rozwoju bólów migrenowych [24,25].…”

Section: A a B B S S T T R R A A C C T Tunclassified

Czy wskaźnik masy ciała i stężenie lipidów w surowicy wpływają na częstość występowania i przebieg migreny?

Chorążka

Janoska

Świć

et al. 2013

Neurologia i Neurochirurgia Polska

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Migraine is a well-known condition for many medical specializations. Some authors evaluate the potential impact of the abnormal body mass index (BMI) and abnormal lipid profile on the vulnerability to migraine and its severity. Regarding the fact that these factors have the inseparable connection with the risk of cardiovascular diseases, some papers bring the hypotheses of the probable role of migraine in the progression of such conditions. Some research suggests a link between abnormal BMI and a risk of migraine and its more severe course. When it comes to a lipid panel in migraine, the most frequent abnormalities are elevated levels of total cholesterol and low-density lipoprotein cholesterol which may contribute to the increased risk of migraine. High-density lipoprotein and triglycerides levels were not contributory in most of the papers. We present the latest views on the mentioned problems focusing on differences in results of the particular works.

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Frequency of the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene in patients with migraine with or without aura – a preliminary report

Cited by 10 publications

References 25 publications

Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case‐Control Study

Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case‐Control Study

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

Czy wskaźnik masy ciała i stężenie lipidów w surowicy wpływają na częstość występowania i przebieg migreny?

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