Frequency of the canine leucocyte adhesion deficiency (CLAD) mutation among Irish red setters in Germany

Pfeiffer, I.; Brenig, Bertram

doi:10.1111/j.1439-0388.2005.00500.x

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…The mutation was found in all ten countries included in the study (Kijas et al, 2000). Other studies estimated mutant allele frequencies between 7.6% and 13.0% in the USA (Foureman et al, 2002), 7.6% in Australia (Jobling et al, 2003) and 11.0% in Germany (Pfeiffer and Brenig, 2005). The frequency of the CLAD-mutation in the Belgian population has apparently been reduced to near zero during the last 15 years, which is proof of the efficiency of using DNA-testing to decrease genetic disorders.…”

Section: Irish Settermentioning

confidence: 58%

Frequentieschatting van ziekteveroorzakende mutaties in de Belgische populatie van enkele hondenrassen: Deel 2: retrievers en andere rastypes

Beckers¹,

Poucke²,

Ronsyn³

et al. 2016

Vlaams Diergeneeskundig Tijdschrift

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A Belgian population of ten breeds with a low to moderately low genetic diversity or which are relatively popular in Belgium, i.e. Bichon frise, Bloodhound, Bouvier des Flandres, Boxer, Cavalier King Charles spaniel, Irish setter, Papillon, Rottweiler, Golden retriever and Labrador retriever, was genotyped for all potentially relevant disease-causing variants known at the start of the study. In this way, the frequency was estimated for 26 variants in order to improve breeding advice. Disorders with a frequency high enough to recommend routine genotyping in breeding programs are (1) degenerative myelopathy for the Bloodhound, (2) arrhythmogenic right ventricular cardiomyopathy and degenerative myelopathy for Boxers, (3) episodic falling syndrome and macrothrombocytopenia for the Cavalier King Charles spaniel, (4) progressive retinal atrophy rod cone dysplasia 4 for the Irish setter (5) Golden retriever progressive retinal atrophy 1 for the Golden retriever and (6) exercise induced collapse and progressive rod-cone degeneration for the Labrador retriever. To the authors’ knowledge, in this study, the presence of a causal mutation for a short tail in the Bouvier des Flandres is described for the first time.

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Section: Irish Settermentioning

confidence: 58%

Frequentieschatting van ziekteveroorzakende mutaties in de Belgische populatie van enkele hondenrassen: Deel 2: retrievers en andere rastypes

Beckers¹,

Poucke²,

Ronsyn³

et al. 2016

Vlaams Diergeneeskundig Tijdschrift

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“…Furthermore, variations in the circulating lymphocyte subpopulations [42], and polymorphisms in cytokine genes involved in the regulation of Th1/Th2 balance, such as interleukin-10 [43], could contribute to non-responding. Finally, primary immunodeficiency syndromes can be responsible for non-responding, such as canine leucocyte adhesion deficiency, e. g., in Setters [44][45][46][47]. It is unknown whether humoral non-responders have also impaired cellular immune responses, and thus generally a higher risk for acquiring disease.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Neutralizing Antibodies to Canine Distemper Virus and Response to Vaccination in Client-Owned Adult Healthy Dogs

Bergmann¹,

Freisl²,

Zablotski³

et al. 2021

Viruses

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Re-vaccinations against canine distemper virus (CDV) are commonly performed in 3-year intervals. The study’s aims were to determine anti-CDV antibodies in healthy adult dogs within 28 days of vaccination against CDV, and to evaluate factors associated with the presence of pre-vaccination antibodies and with the antibody response to vaccination. Ninety-seven dogs, not vaccinated within 1 year before enrollment, were vaccinated with a modified live CDV vaccine. A measurement of the antibodies was performed before vaccination (day 0), on day 7, and 28 after the vaccination by virus neutralization. A response to vaccination was defined as a ≥4-fold titer increase by day 28. Fisher’s exact test was used to determine factors associated with a lack of antibodies and vaccination response. In total, 94.8% of the dogs (92/97; CI 95%: 88.2–98.1) had antibodies (≥10) prior to vaccination. A response to vaccination was not observed in any dog. Five dogs were considered humoral non-responders; these dogs neither had detectable antibodies before, nor developed antibodies after vaccination. Young age (<2 years) was significantly associated with a lack of pre-vaccination antibodies (p = 0.018; OR: 26.825; 95% CI: 1.216–1763.417). In conclusion, necessity of re-vaccination in adult healthy dogs should be debated and regular vaccinations should be replaced by antibody detection.

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“…From a clinical standpoint, knowledge of the frequency of the mutated allele is valuable for establishing the relative importance of the disease among similar syndromes. 8 Since, to the authors' knowledge, these data are not available, a study was undertaken to ascertain the frequency of the allele responsible for CNM as well as to estimate the prevalence of the disease using a convenience-sample population of Labrador Retrievers examined for unrelated complaints at the Veterinary Clinical Department of the University of Bologna (Ozzano dell'Emilia, Bologna, Italy) or at a commercial laboratory over a period of 8 years known to be affected with CNM. Nucleic acids were purified using a commercial extraction kit, a following the manufacturer's instructions with minimal modifications.…”

mentioning

confidence: 99%

Frequency of the Allelic Variant of the PTPLA Gene Responsible for Centronuclear Myopathy in Labrador Retriever Dogs as Assessed in Italy

et al. 2011

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Abstract. Centronuclear myopathy (CNM) is an autosomal recessive hereditary disease affecting Labrador Retriever dogs. The disease is characterized by muscle lesions, typically encompassing reduction in the number and atrophy of type II fibers, and is caused by a short interspersed repeat element insertion in exon 2 of the protein tyrosine phosphatase-like member A. The actual allele frequency is unknown; a study was undertaken to ascertain it using a convenience-sample population composed of 217 Labrador Retrievers. In addition to 3 subjects already diagnosed with CNM, used as positive controls for polymerase chain reaction, only 2 unrelated dogs were heterozygous wild-type/mutation (wild-type/mut). Thus, the frequency of the CNM allele observed in the present study was 1.8% and 0.47% when including and excluding the 3 mut/ mut homozygous cases, respectively. Based on the Hardy-Weinberg exact test (P 5 1.00), the genotype frequency without the CNM-affected dogs was in agreement with the Hardy-Weinberg equilibrium. Assuming the Hardy-Weinberg equilibrium law, the expected frequency of the homozygous mutated genotype was calculated to be approximately 0.00005, which corresponds to 1 case of CNM out of 20,000 dogs. In conclusion, the present study indicates that the CNM allele is present but rare in a convenience sample of Labrador Retrievers in Italy.

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Frequency of the canine leucocyte adhesion deficiency (CLAD) mutation among Irish red setters in Germany

Cited by 9 publications

References 9 publications

Frequentieschatting van ziekteveroorzakende mutaties in de Belgische populatie van enkele hondenrassen: Deel 2: retrievers en andere rastypes

Frequentieschatting van ziekteveroorzakende mutaties in de Belgische populatie van enkele hondenrassen: Deel 2: retrievers en andere rastypes

Prevalence of Neutralizing Antibodies to Canine Distemper Virus and Response to Vaccination in Client-Owned Adult Healthy Dogs

Frequency of the Allelic Variant of the PTPLA Gene Responsible for Centronuclear Myopathy in Labrador Retriever Dogs as Assessed in Italy

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