Frequency of Thrombocytopenia in Patient With Malaria Presented to Khyber Teaching Hospital Peshawar, Pakistan

Abstract

Background: Malaria is a fatal infectious disease which is associated with numerous complications and has a profound effects on the blood indices. Thrombocytopenia is frequently reported among the patients with malaria though it is not an indication of the severity of the disease.
 
 Objective: 
 The aim of the current study is to observe the hematological changes particularly the incidence of thrombocytopenia among the patients with malaria presented to the Khyber Teaching Hospital, Peshawar.
 Methodology: 
 A descriptive cross-sectional study was conducted at the Medicine Department of Khyber Teaching Hospital, Peshawar from August 2018 to February 2019. A total of 95 malaria parasite (MP) positive cases were included in the study. The patients’ demographic details and the hematological variables were recorded. Data was analyzed using SPSS Version 20.0.
 Results: 
 Among 95 MP positive patients, 88 had Plasmodium vivax infection while 7 patients were suffering from Plasmodium falciparum malaria. Moreover, 89 (93.6%) were found to have thrombocytopenia with majority having grade 1 thrombocytopenia (52.6%). while leukopenia was seen among 29.5% of the cases and only 5.3% presented with leukocytosis. The level of Hb
 was normal in majority of the cases and only 27.4% had Hb<11.5g/dl.
 
 Conclusion: 
 Thrombocytopenia is a common hematological finding among the patients suffering from malaria. Our study findings favor the diagnostic implications of thrombocytopenia as an indicator of acute malaria.

Frequency of Thrombocytopenia in Malaria Patient at Tertiary Care Hospital

“…Amongst patients with thrombocytopenia, grade 1 thrombocytopenia was observed in 50% patients, grade 2 in 25.33% patients, grade 3 in 15.33% patients while grade 4 thrombocytopenia was observed in 9.33% patients. In accordance with our study, another study reported almost similar results 19 . The precise cause of malarial thrombocytopenia is uncertain.…”

“…An earlier study done by MUHAMMAD ASIF et al reported that p.vivax malaria is more common in Pakistan as compared to p. falciparum 18 . Another study carried out by Hamza Ali Khan et al observed similar results and reported that p.vivax malaria was present amongst 92.7% patients while p. falciparum was observed only in 7.3% patients 19 . In the current study, the overall frequency of thrombocytopenia amongst 150 patients with malaria was 90% (n=135).…”

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“…One or more attacks of acute tonsillitis per year is common in children of primary school age. 7 Tonsils undergo involution at puberty, but this can be hampered if the tonsillar tissues and cells are not permanently damaged. Children who experience acute tonsillitis with adequate treatment are at lower risk of experiencing enlarged tonsils compared to patients who experience recurrent tonsillitis or chronic tonsillitis.…”

“…Tarasov and Morozov also conducted health checks on children and adults, found a total of 190-230 ENT diseases per 1,000 population, and 38.4% of them suffered from chronic tonsillitis. 7,8 World Health Organization In 2013, the number of cases of chronic tonsillitis was estimated at 287,000 children under 15 years. 9 Research conducted at Sarawak Hospital in Malaysia in the period July 2003 to June 2004, out of 657 patients with chronic tonsillitis, 342 men (52%) were found and 315 women (48%).…”

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