Frequency of vacA, cagA and babA2 virulence markers in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis

Paniagua, Gloria Luz; Monroy, Eric; Rodríguez, Ricardo Zamora; Arroniz, Salvador; Rodríguez, C.; Cortés, José Luis; Camacho, Ausencio; Negrete, Erasmo; Vaca, Sergio

doi:10.1186/1476-0711-8-14

Cited by 46 publications

(50 citation statements)

References 44 publications

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“…A statistically significant association was observed between cagA, cagE, vacA genes and babA2 (p<0.05) ( Table 3), but other authors did not find any association between these pathogenicity genes in the samples they investigated 23,32,33 . Our data, however, supports the relationship between the genes cagA, cagE, vacA and babA2 that was described in previous reports [34][35][36][37] .…”

Section: Discussionmentioning

confidence: 84%

cagE as a biomarker of the pathogenicity of Helicobacter pylori

Ramis

Vianna

Silva

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction:Helicobacter pylori infection is associated with gastro-duodenal diseases. Genes related to pathogenicity have been described for H. pylori and some of them appear to be associated with more severe clinical outcomes of the infection. The present study investigates the role of cagE as a pathogenicity biomarker of H. pylori compare it to cagA, vacA, iceA and babA2 genes and correlate with endoscopic diagnoses. Methods: Were collected biopsy samples of 144 dyspeptic patients at the Hospital of the Federal University of Rio Grande, Rio Grande do Sul, Brazil. After collection, the samples were sent for histological examination, DNA extraction and detection of all putative pathogenicity genes by PCR. Results: Of the 144 patients undergoing endoscopy, 57 (39.6%) presented H. pylori by histological examination and PCR by detection of the ureA gene. Based on the endoscopic diagnoses, 45.6% (26/57) of the patients had erosive gastritis, while 54.4% (31/57) had enanthematous gastritis. The genes cagA, cagE, vacAs1/m1, vacAs1/m2 and iceA1 were related to erosive gastritis, while the genes vacAs2/m2, iceA2 and babA2 were associated to enanthematous gastritis. We found a statistically significant association between the presence of cagE and the endoscopic diagnosis. However, we detect no statistically significant association between the endoscopic diagnosis and the presence of cagA, vacA, iceA and babA2, although a biological association has been suggested. Conclusions: Thus, cagE could be a risk biomarker for gastric lesions and may contribute to a better evaluation of the H. pylori pathogenic potential and to the prognosis of infection evolution in the gastric mucosa.

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Section: Discussionmentioning

confidence: 84%

cagE as a biomarker of the pathogenicity of Helicobacter pylori

Ramis

Vianna

Silva

et al. 2013

Rev. Soc. Bras. Med. Trop.

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show abstract

“…On the contrary, Paniagua, et al 2009 [54] reported that no statistically significant association was observed between vacA s1, cagA and babA2 virulence markers and Abdullah, et al 2013[43] reported that babA2 positive strains were significantly more likely to be cagA positive and they did not find a significant association between cagA status and vacA s2, vacA m1, vacA m2 subtypes. As regards the relationship between H. pylori virulence factors and endoscopic findings, cagA positive isolates had the highest frequency, followed by vacA s1a and vacA m2 while babA2 positive isolates had the least frequency in most patients with PUD, NUD, gastritis and duodenitis.…”

Section: )[32]mentioning

confidence: 99%

Clinical Relevance of the cagA,vacA and babA2 Virulence Factors ofHelicobacter pylori in Egyptian Patients with Gastroduodenal Diseases.

Toukhy¹,

Saeed²,

Emara³

2016

IJAR

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“…2017; 10(12):e60947. (13,14). Numerous documents revealed that H. pylori expression babA are related to more severe mucosal cellular inflammation and increased risk of clinical outcome diseases like active gastritis, peptic ulcer, and gastric cancer (15).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Helicobacter pylori Virulence Related Genes (hpa and babA2) in Iranian Patients with Gastrointestinal Disorders

Heidari

Nezhad

Noroozi

et al. 2017

Jundishapur J Microbiol

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Background: The clinical result severity of Helicobacter pylori infection is determined by a combination of environmental factors, host genetic background, and H. pylori virulence factors. A number of genes containing vacA, iceA, babA2, cagA, cagE, hsp60-70, and hpa have been identified to enhance H. pylori pathogenicity by encoding virulent proteins. The babA and hpa proteins are considered 2 major adhesion molecules, and thus they are key agents in the initial step of H. pylori invasion. Objectives: This study aimed at investigating the existence of babA2 and hpa virulence factors of H. pylori in Iranian patients with gastrointestinal complications. The relationship between these agents and clinical results was also investigated. Methods: A total of 80 positive biopsies out of 156 samples were studied to determine babA2 and hpa gene frequency by PCR. The positive biopsies were collected from patients suffering from gastric cancer (n =18), peptic ulcer (n = 26), and gastritis (n =36). Results:The babA2+ strains were found in 51 (64%) patients and the hpa+ strains in 57 (71%) patients were associated with sex (P = 0.02). However, the frequency of these factors was not significant between gastric disease groups (P > 0.05). Conclusions: Our results revealed different frequency of these virulence factors in Iran, which emphasized the effects of geographical influences. Also, it was found that male patients had higher rate of hpa than females, highlighting the gender specific factors.

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Frequency of vacA, cagA and babA2 virulence markers in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis

Cited by 46 publications

References 44 publications

cagE as a biomarker of the pathogenicity of Helicobacter pylori

cagE as a biomarker of the pathogenicity of Helicobacter pylori

Clinical Relevance of the cagA,vacA and babA2 Virulence Factors ofHelicobacter pylori in Egyptian Patients with Gastroduodenal Diseases.

The Prevalence of Helicobacter pylori Virulence Related Genes (hpa and babA2) in Iranian Patients with Gastrointestinal Disorders

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