Frequency of vitamin D insufficiency in healthy children between 1 and 16 years of age in Turkey

Akman, Alkım Öden; Tümer, Leyla; Hasanoğlu, Alev; İlhan, Mustafa; Çayci, Banu

doi:10.1111/j.1442-200x.2011.03486.x

Cited by 52 publications

(22 citation statements)

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“…In neonates, the lowest rate reported was 53.3% (95% CI: 46.6-66.8) in a study performed in Istanbul by Ozdemir et al [7], and the highest rate was 93% (95% CI: 89.2-95.5) in a study conducted in Izmir by Halicioglu et al [8]. In children, the lowest rate was determined to be 8% (95% CI: 6-10) in a study in Ankara investigated by Akman et al [19], and the highest rate was reported as 82% (95% CI: 79.1-84.6) in a study in Trabzon conducted by Karaguzel et al [15] In adults, the lowest rate determined was 34%, observed in a study in İstanbul performed by Buyukuslu et al [29], and the highest rate was 91%, reported by Bozkurt et al in a study carried out in Ankara (Fig. 2-7).…”

Section: Resultsmentioning

confidence: 95%

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Vitamin D deficiency status in Turkey: A meta-analysis

Alpdemir¹

2019

Int J Med Biochem

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INTERNATIONAL JOURNAL OF MEDICAL BIOCHEMISTRY Meta Analysis Vitamin D deficiency status in Turkey: A meta-analysis V itamin D is a steroid hormone that has a major role in bone mineralization through the regulation of calcium and phosphorus metabolism. The main sources of vitamin D are cutaneous synthesis and the ingestion of food, especially fish oil, eggs, and liver [1]. The most common forms of vitamin D absorption are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D3 is synthesized in the skin through sunlight exposure. This inactive form of vitamin D3 is then metabolized to the prohormone form, 25-hydroxyvitamin (OH)D3, in the liver. The biologically effective form, 1.25(OH)D3, is produced in the kidneys and has a half-life of approximately 2 to 3 weeks, while the circulating half-life of 1.25(OH)D is only 4 to 6 hours. Therefore , 25(OH)D3 is generally considered a measure of vitamin D status [1]. Vitamin D has a substantial function in the maintenance of bone health. A deficiency of vitamin D has been associated with the increased risk of a number of chronic conditions, including cardiovascular disease, diabetes, hypertension, some cancers, autoimmune diseases, neuropsychiatric disorders, metabolic disorders and infectious diseases associated with decreased immunity [2, 3]. The deficiency of vitamin D is a significant problem of public health in both the developed world and developing countries, with a reported prevalence of 30% to 80% of children and adults worldwide [4, 5]. There is not currently enough infor-Objectives: Vitamin D deficiency is a significant public health problem in both developed and developing countries, with a reported worldwide prevalence of 30% to 80% among children and adults. The purpose of this study was to examine vitamin D deficiency/insufficiency in Turkey based on a review of the existing research. Methods: PubMed, DergiPark, The Scientific and Technological Research Council of Turkey (TUBITAK), Google Scholar, Google, and Scopus search engines were queried. The keywords of Turkey, vitamin D, serum 25-hydroxyvitamin D, 25(OH)D3, 25(OH) vitamin D, deficiency/insufficiency of vitamin D, and prevalence were used in the screening process. The review included prospective and retrospective research studies with healthy individuals of various communities. The Newcastle-Ottawa Quality Assessment Scale was used to assess the risk of bias of the included studies. Results: A total of 40 studies with a sample size of 111.582 were included in the meta-analysis. The prevalence of vitamin D deficiency was estimated at 63% (95% confidence interval [CI]: 58.9-66.6) for the overall population. It was observed that vitamin D deficiency has been reported as 86.6% (95% CI: 70.2-94.6) for infants, 76% (95% CI: 65.2-84.3) for pregnant women, 39.8% (95% CI: 38-41.6) for children, and 63.5% (95% CI: 58.8-67.9) for adults. The prevalence of vitamin D deficiency among women and men was identified as 64.7% (95% CI: 57.5-71.2) and 39.5% (95% CI: 31.0-48.7), respectively. Conclusion...

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Section: Resultsmentioning

confidence: 95%

“…In a study performed on adolescent girls in Turkey, Hatun et al [14] found a rate of deficiency of vitamin D of [18]. Akman et al [19] found that there was vitamin D deficiency and inadequacy of 8% and 25.5%, respectively, in healthy children aged 1-16. Table 3 displays the results obtained from studies of adults.…”

Section: Children and Adolescentsmentioning

confidence: 99%

Vitamin D deficiency status in Turkey: A meta-analysis

Alpdemir¹

2019

Int J Med Biochem

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“…Because vitamin D has a positive influence on calcium balance for building bone and attaining peak bone mass, vitamin D deficiency or insufficiency can contribute to BMD deficit [22]. The prevalence of 25-hydroxyvitamin D (25-OH-D) insufficiency is reported to be 14-49% in the general population and was reported to be between 33.5% and 40% in healthy Turkish children and adolescents in two recent studies [23,24,25,26]. In a recent study of 484 childhood cancer survivors, 17.6% of whom had leukemia, Choudhary et al reported a prevalence of 29% of 25-OH-D insufficiency, and the risk factors for 25-OH-D insufficiency were race, pubertal status, and seasonality [27].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Endocrine Late Complications in Childhood Acute Lymphoblastic Leukemia Survivors: A Report of a Single-Center Experience and Review of the Literature

Bayram¹,

Yaralı²,

Fettah³

et al. 2017

Tjh

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Objective:Improvement in long-term survival in patients with acute lymphoblastic leukemia (ALL) in childhood has led to the need for monitorization of treatment-related morbidity and mortality. In the current study, we aimed to evaluate endocrine side effects of treatment in ALL survivors who were in remission for at least 2 years.Materials and Methods:Sixty patients diagnosed with ALL, who were in remission for at least 2 years, were cross-sectionally evaluated for long-term endocrine complications.Results:The median age of the patients at the time of diagnosis, at the time of chemotherapy completion, and at the time of the study was 5 years (minimum-maximum: 1.7-13), 8 years (minimum-maximum: 4.25-16), and 11.7 years (minimum-maximum: 7-22), respectively, and median follow-up time was 4 years (minimum-maximum: 2-10.1). At least one complication was observed in 81.6% of patients. Vitamin D insufficiency/deficiency (46.6%), overweight/obesity (33.3%), and dyslipidemia (23.3%) were the three most frequent endocrine complications. Other complications seen in our patients were hyperparathyroidism secondary to vitamin D deficiency (15%), insulin resistance (11.7%), hypertension (8.3%), short stature (6.7%), thyroid function abnormality (5%), precocious puberty (3.3%), and decreased bone mineral density (1.7%). There were no statistically significant correlations between endocrine complications and age, sex, and radiotherapy, except vitamin D insufficiency/deficiency, which was significantly more frequent in pubertal ALL survivors compared to prepubertal ALL survivors (57.5% and 25%, respectively, p=0.011).Conclusion:A high frequency of endocrine complications was observed in the current study. The high frequency of late effects necessitates long-term surveillance of this population to better understand the incidence of late-occurring events and the defining of high-risk features that can facilitate developing intervention strategies for early detection and prevention.

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“…Prevalence studies on vitamin D deficiency and/or insufficiency in the Turkish population, especially among prepubertal children over 3 years of age, are relatively scarce (9). The aim of this study was to determine the frequency of deficiency and insufficiency of vitamin D in a sample of Turkish children and adolescents and to investigate the factors associated with low vitamin D status.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency in Children and Adolescents

Andıran

Çelik²,

Akça³

et al. 2012

jcrpe

163

114

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Objective Vitamin D deficiency is an important health problem in both developed and developing countries. Recent reports on the extraskeletal effects of vitamin D have led to increased interest in prevalence studies on states of deficiency/insufficiency of vitamin D. The aim of this study was to determine the frequency of vitamin D deficiency and insufficiency in children and adolescents residing in Ankara, Turkey and to investigate the factors associated with low vitamin D status. Methods: A total of 440 children and adolescents aged between 0 and 16 years were enrolled in this study. The subjects were divided into three groups according to their vitamin D status (deficiency ≤15 ng/mL; insufficiency: 15-20 ng/mL; sufficiency ≥20 ng/mL) and also according to their age (preschool<5 years; middle childhood: 5-10 years; adolescence: 11-16 years). Results: Overall, 40% of the subjects were found to have 25 hydroxy vitamin D [25(OH)D] levels of less than 20 ng/mL. The levels indicated a deficiency state in 110 subjects (25%) and insufficiency - in 66 (15%). The rate of vitamin D deficiency was higher in girls, regardless of age. 25(OH)D levels correlated negatively with age (r=-0.48, p<0.001), body mass index (BMI) (r=-0.20, p=0.001) and intact parathyroid hormone (iPTH) level (r=-0.31, p=0.001). A positive correlation was observed between 25(OH)D and serum ferritin levels (r=0.15, p=0.004). Conclusions: The high frequency of vitamin D deficiency in childhood (especially among adolescent girls) indicates a need for supplementation and nutritional support. Conflict of interest:None declared.

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Frequency of vitamin D insufficiency in healthy children between 1 and 16 years of age in Turkey

Cited by 52 publications

References 47 publications

Vitamin D deficiency status in Turkey: A meta-analysis

Vitamin D deficiency status in Turkey: A meta-analysis

Evaluation of Endocrine Late Complications in Childhood Acute Lymphoblastic Leukemia Survivors: A Report of a Single-Center Experience and Review of the Literature

Vitamin D Deficiency in Children and Adolescents

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