Frequency response analysis for MSMPR crystallizer with modulated feed flow rate: A method for studying secondary nucleation mechanism

Bal, Vivekananda

doi:10.1016/j.jcrysgro.2021.126426

Cited by 1 publication

(1 citation statement)

References 41 publications

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“…Though stirring helps reduce thermal and concentration gradients, it also causes particle breakage [5,6]. Additionally, non-ideal mixing behavior results in residence time distributions that widen crystal size distribution [7,8]. MSMPR is unable to resolve the problems associated with batch crystallizers like, non-uniform temperature control and localized shear regions [9].…”

Section: Introductionmentioning

confidence: 99%

Cooling Crystallization of Paracetamol in a Slug-Flow Crystallizer with Silicone Oil as Continuous Phase

Nandan

Parambil

2023

Crystals

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Continuous tubular crystallizers that can provide high yield and better control of crystal size would be of great interest to the industrial crystallization process. However, most continuous crystallizer designs face challenges either due to surface fouling or crystal breakage. In this paper, we explore the ability of slug-flow cooling crystallizers to continuously generate acetaminophen crystals using silicone oil as the continuous phase. Each slug acts as a crystallizer, and the crystals formed inside the dispersed phase avoid encrustation. Three crystallizer configurations were studied at a wide range of supersaturation and flow rates. It was found that a narrow crystal size distribution can be achieved at high flow rates and high supersaturation. Additionally, the average crystal size and the crystallization yield increased with supersaturation and residence time. The configuration of the tubular crystallizer was found to influence the crystallization yield by affecting the internal mixing in the slugs. With further studies, slug-flow cooling crystallizer can be developed for continuous crystallization of crystals with a narrow size distribution, polymorphic purity, and good yield.

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