Simple yet ultrasensitive and accurate quantification
of a variety
of analytical targets by virtue of a universal sensing device holds
promise to revolutionize environmental monitoring, medical diagnostics,
and food safety. Here, we propose a novel optical surface plasmon
resonance (SPR) system in which the frequency-shifted light of different
polarizations returned the laser cavity to stimulate laser heterodyne
feedback interferometry (LHFI), hence amplifying the reflectivity
change caused by the refractive index (RI) variations on the gold-coated
SPR chip surface. In addition, the s-polarized light
was further used as the reference to compensate the noise of the LHFI-amplified
SPR system, resulting in nearly 3 orders of magnitude enhancement
of RI resolution (5.9 × 10–8 RIU) over the
original SPR system (2.0 × 10–5 RIU). By exploiting
nucleic acids, antibodies, and receptors as recognition materials,
a variety of micropollutants were detected with ultralow detection
limits, ranging from a toxic metal ion (Hg2+, 70 ng/L)
to a group of commonly occurring biotoxin (microcystins, 3.9 ng microcystin-LR/L)
and a class of environmental endocrine disruptors (estrogens, 0.7
ng 17β-estradiol/L). This sensing platform exhibits several
distinct characteristics, including dual improvement of sensitivity
and stability and common-path optical construction without needing
optical alignment, demonstrating a promising avenue toward environmental
monitoring.