1999
DOI: 10.3892/or.6.6.1223
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Frequent allelic loss/imbalance on the long arm of chromosome 21 in oral cancer: evidence for three discrete tumor suppressor gene loci.

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Cited by 22 publications
(18 citation statements)
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“…Putative tumor suppressor gene(s), which may play an important role in oral squamous cell carcinogenesis, are located on the arms of several chromosomes. Our previous studies of LOH at 21p for primary oral SCCs showed allele loss in 44% of informative cases 21) . Recent studies have indicated that the chromosome 3p arm in frequently altered in patients with several types of malignant tumors, including nasopharyngeal cancer 14) , ovarian cancer 2) and oral cancer 7,13) .…”
Section: Discussionmentioning
confidence: 90%
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“…Putative tumor suppressor gene(s), which may play an important role in oral squamous cell carcinogenesis, are located on the arms of several chromosomes. Our previous studies of LOH at 21p for primary oral SCCs showed allele loss in 44% of informative cases 21) . Recent studies have indicated that the chromosome 3p arm in frequently altered in patients with several types of malignant tumors, including nasopharyngeal cancer 14) , ovarian cancer 2) and oral cancer 7,13) .…”
Section: Discussionmentioning
confidence: 90%
“…Despite the clinical relevance, very little is known about the molecular basis of tongue SCC, compared to other human malignancies 21) . Inactivation of tumor suppressor genes and activation of oncogenes have been considered to play important roles in the multi-step process of human tumorigenesis.…”
Section: Introductionmentioning
confidence: 99%
“…A homozygous deletion of the gene was found in a human non-small cell lung cancer cell line, suggesting that the gene is a candidate TSG (Kohno et al, 1998). In our previous study, frequent allelic loss was identified on chromosome arm 21q21 that includes the ANA gene locus in primary OSCCs (Yamamoto et al, 1999). Thus, we hypothesized that loss of function of the ANA gene could contribute to the tumorigenesis of OSCC.…”
Section: Discussionmentioning
confidence: 99%
“…These observations suggest that more than one TSG specific to several types of human malignancies may exist on 21q. In our previous study, 3 potential TSG loci were identified on 21q in OSCCs (Yamamoto et al, 1999). Of them, the most frequently deleted region was identified on 21q11.1, which is near the ANA gene locus.…”
Section: Discussionmentioning
confidence: 99%
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