Contemporary global work comprises a wide and growing array of different modes of international work configurations. In this article, we offer a multidimensional framework for conceptual (theoretical and practical) underpinning of these different modes. Building on the extant literature and the Delphi approach, seven dimensions emerged: (i) time of exposure; (ii) intensity of international contact through work; (iii) breadth of interaction; (iv) legal context; (v) international work instigator; (vi) extent of cultural gap between an individual's country-of-origin and the context in which the international work takes place; and (vii) key cultural-related requirements of one's job/role. To these dimensions, we add individual and organizational contextual variables, e.g. diversity and occupational patterns, as well as career systems with a particular focus on the importance of globally orientated work. Furthermore, we list the major modes of global careers and draw a global career glossary. Both the multidimensional framework and the glossary should facilitate scholars and managers to systematize, analyse, manage and further develop their expatriation and repatriation career strategies, policies and practices.