Frequent DNA methylation of MiR‐129‐2 and its potential clinical implication in hepatocellular carcinoma

Lu, Chang-Yi; Lin, Kai-Yuan; Tien, Meng-Tsung; Wu, Chih Chiang; Uen, Yih-Huei; Tseng, Tzu‐Ling

doi:10.1002/gcc.22059

Cited by 52 publications

(42 citation statements)

References 19 publications

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“…miR-129 down-regulation is tightly associated with disease stages and progression, and its down-regulation is attributed to hypermethylation of its promoter (Yu et al, 2013). Similar down-regulation in miR-129 was also observed in hepatocellular carcinoma (Lu et al, 2013;Chen, et al, 2013). These results suggest that miR-129 plays a crucial role in tumorigenesis.…”

Section: Introductionsupporting

confidence: 54%

miR-129b suppresses cell proliferation in the human lung cancer cell lines A549 and H1299

Zheng¹,

Qi²,

Liu³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Lung cancer is one of the most prevalent malignant tumors, and is one of the primary causes of cancer-associated deaths. In 2002, an estimated 1.18 million lung cancer-associated deaths were recorded, accounting for 18% of cancer-related deaths and 2% of total mortality. Despite the great progress that has been made in lung cancer therapies, the mechanisms underlying lung cancer formation and development remain largely unknown. Meanwhile, the microRNA miR-129 has been shown to be involved in the formation of many types of cancer. Therefore, this study aims to investigate whether miR129b could suppress proliferation of lung cancer cell lines. NSCLC tissue samples were collected from the Department of Respiratory Medicine between April 2013 and December 2015. Ten normal health individuals were recruited as controls. Lung cancer cell lines A549 and H1299 were used to examine the suppressive effects of miR129b. Quantitative real-time PCR was used to detect miR129b expression. The MTT assay was used to analyze cell proliferation. Results indicated that miR129b is down-regulated in lung cancer cell lines and NSCLC tissues. Furthermore, overexpression of miR-129b inhibited proliferation of lung cancer cells. In conclusion, miR-129b suppresses lung cancer cell proliferation, and can be a potential therapeutic target for treatment of lung cancers.

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Section: Introductionsupporting

confidence: 54%

miR-129b suppresses cell proliferation in the human lung cancer cell lines A549 and H1299

Zheng¹,

Qi²,

Liu³

et al. 2016

Genet. Mol. Res.

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show abstract

“…One investigation showed that miR-129-2 was frequently hypermethylated in HCC cells and clinical samples, offering a potential methylation marker for HCC diagnosis [10]. Another study identified the down-regulated expression of miR-129-2 in HCC tissues in a manner reversely correlated with the level of miR-129-2 methylation.…”

Section: Dna Methylation and Mir-129 Expressionmentioning

confidence: 99%

“…Human miR-129-1 is among the seven miRNAs recognized in genomic regions near FRA7H, one of the fragile sites in chromosome 7q32 which is frequently deleted in some solid tumors [9]. MiR-129 family members are generally recognized as tumor suppressors with decreased expression in different tumors [10][11][12][13][14][15][16]. However, accumulating evidence indicates that miR-129 could play a dual role in tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

Gao¹,

Feng²,

Han³

et al. 2016

Cell Physiol Biochem

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Emerging evidence has shown that microRNAs (miRNAs) play essential roles in regulating human cancers development and progression. However, the underlying mechanisms remain to be further explored. MiRNAs are a class of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs that moderate gene expression primarily at post-transcriptional level. There is a growing body of literature that recognizes the importance of microRNA (miR)-129 during the development of cancers. Aberrant expression of miR-129 has been detected in various types of human cancers and the validated target genes are involved in cancer-related biological processes such as DNA methylation, cell proliferation, apoptosis, cell cycle, and metastasis. In this review, we summarized the roles of miR-129 family members and their target genes in tumorigenesis and clinical treatment of human cancers, highlighting the potential roles of miR-129 as biomarkers for cancer diagnosis and prognosis, and promising tools for cancer treatment.

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“…For this reason, its potential utility as an early diagnostic marker for HCC was studied Lu et al, 2013).…”

Section: Mir-129-2mentioning

confidence: 99%

HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

Bronte

Fanale

et al. 2016

Critical Reviews in Oncology/Hematology

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Frequent DNA methylation of MiR‐129‐2 and its potential clinical implication in hepatocellular carcinoma

Cited by 52 publications

References 19 publications

miR-129b suppresses cell proliferation in the human lung cancer cell lines A549 and H1299

miR-129b suppresses cell proliferation in the human lung cancer cell lines A549 and H1299

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

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