Frequent downregulation of DMBT1 and galectin‐3 in epithelial skin cancer

Mollenhauer, Jan; Deichmann, Martin; Helmke, Burkhard; Müller, Hanna; Kollender, Gaby; Holmskov, Uffe; Ligtenberg, Toon; Krebs, Inge; Wiemann, Stefan; Bantel-Schaal, Ursula; Madsen, Jens; Bikker, Floris J.; Klauck, Sabine M.; Otto, Herwart F.; Moldenhauer, G; Poustka, Annemarie

doi:10.1002/ijc.11072

Cited by 45 publications

(49 citation statements)

References 25 publications

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“…17 CDCP1 contains three CUB domains, which are thought to play biological roles by mediating protein-protein interaction, in various molecules such as galectins, DMBT1, 18 sperm adhesine, 19 neuropilin, 20 and proteases including Bmp1/ C-proteinase, Tolloid, and MASP. 7 Recently, it is reported that some type of CUB domain binds to fibronectin and modulates interaction of the other matrix components.…”

Section: Discussionmentioning

confidence: 99%

CUB-Domain-Containing Protein 1 Regulates Peritoneal Dissemination of Gastric Scirrhous Carcinoma

Uekita¹,

Tanaka²,

Takigahira³

et al. 2008

The American Journal of Pathology

102

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CUB-domain-containing protein 1 (CDCP1) is a type-I transmembrane protein that is highly expressed in colon, breast, and lung cancers. We recently revealed that CDCP1 is associated with and phosphorylated by Src family kinases and is involved in the regulation of anchorage independence of certain lung cancer cell lines. In this study, we examined whether CDCP1 is involved in the regulation of tumor progression of scirrhous gastric cancer, which is a diffusely infiltrative carcinoma with high invasion potential. Expression and phosphorylation levels of CDCP1 correlated with the invasive potential of scirrhous gastric cancers. Reduction of CDCP1 expression by siRNA suppressed migration, invasion, and anchorage independence without affecting the proliferation of highly invasive scirrhous gastric cancer cells. However, CDCP1 overexpression promoted gastric cancer cell migration with low potential of invasion. Loss of CDCP1 suppressed invasion and dissemination of cancer cells that were orthotopically implanted in the gastric wall of nude mice. Expression and phosphorylation of CDCP1 were also detected in cancer cells of surgically resected tissues of human scirrhous gastric cancer by immunohistochemical analysis. Our results suggest that CDCP1 promotes invasion and peritoneal dissemination of cancer cells through the regulation of cell migration and anchorage independence. Therefore, it is both a potential prognostic and therapeutic target in certain types of gastrointestinal cancers, and suppression of its phosphorylation might be a useful strategy for modulating cancer metastasis. (Am J Pathol

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Section: Discussionmentioning

confidence: 99%

CUB-Domain-Containing Protein 1 Regulates Peritoneal Dissemination of Gastric Scirrhous Carcinoma

Uekita¹,

Tanaka²,

Takigahira³

et al. 2008

The American Journal of Pathology

102

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“…There is a large body of literature supporting an association of DMBT1 with cancer (2,5,23,26,35,37). However, other studies have failed to provide a link between DMBT1 and cancer (20,40,41).…”

Section: Discussionmentioning

confidence: 99%

“…DMBT1 gene expression in humans is strong in lung [weaker in mouse (12)]; at weak levels in brain (21,37); at strong levels in salivary glands (16,29,42); and at weak levels in mammary gland, uterus, testis, and prostate (21). In addition to these tissues, the protein has been detected in human tear fluid (48), sweat glands, hair follicles and epidermis (35), liver (47), alveolar macrophages (21), pancreatic juice (18), bile (28), and airway submucosal gland secretions (49). In general, the gene is expressed most strongly in epithelia and is usually observed on the apical cell surface or in luminal exocrine secretions.…”

mentioning

confidence: 99%

Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system

Lisle

Xu²,

Roe³

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…DMBT1 is expressed mainly by mucosal epithelia and glands, in particular in the respiratory tract [4,5,7]. In adults, research interest in DMBT1 was stimulated by the finding of its possible role in tumour suppression [7,8].…”

Section: Introductionmentioning

confidence: 99%

Respiratory Deleted in Malignant Brain Tumours 1 (DMBT1) levels increase during lung maturation and infection

Müller

End

Weiß

et al. 2007

Clinical and Experimental Immunology

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SummaryDeleted in Malignant Brain Tumours 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds and aggregates various bacteria and viruses in vitro. Studies in adults have shown that DMBT1 is expressed mainly by mucosal epithelia and glands, in particular within the respiratory tract, and plays a role in innate immune defence. We hypothesized that respiratory DMBT1 levels may be influenced by various developmental and clinical factors such as maturity, age and bacterial infection. DMBT1 levels were studied in 205 tracheal aspirate samples of 82 ventilated preterm and fullterm infants by enzyme-linked immunosorbent assay. Possible effects of various clinical parameters were tested by multiple regression analysis. DMBT1 levels increased significantly with lung maturity (P < 0·0001 for both gestational and postnatal age) and in small-for-gestational-age infants (P = 0·0179). An increase of respiratory DMBT1 levels was detected in neonatal infections (P < 0·0001). These results were supported by Western blotting. Immunohistochemical analyses of archived newborn lung sections (n = 17) demonstrated high concentrations of DMBT1 in lungs of neonates with bacterial infections. Our data show that preterm infants are able to up-regulate DMBT1 in infection as an unspecific immune reaction.

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Frequent downregulation of DMBT1 and galectin‐3 in epithelial skin cancer

Cited by 45 publications

References 25 publications

CUB-Domain-Containing Protein 1 Regulates Peritoneal Dissemination of Gastric Scirrhous Carcinoma

CUB-Domain-Containing Protein 1 Regulates Peritoneal Dissemination of Gastric Scirrhous Carcinoma

Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system

Respiratory Deleted in Malignant Brain Tumours 1 (DMBT1) levels increase during lung maturation and infection

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