Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients

Mini review article. Human herpesvirus-6 and the etiology of multiple sclerosis: a literature review

“…Sotelo et al [36] and Hon et al [37] reported HHV-6 DNA absent, Fredj et al [38] in 2.0%, Hay and Tenser, [35] in 14%, and Mameli et al [39] in 21.4% of healthy controls. lvarez-Lafuente et al [31], Alvarez-Lafuenteet al [40], and Chapenko et al [30] reported higher prevalence rates, 30.4%, 21.6%, and 28.7% respectively, while Ablashi et al [41] reported HHV-6 DNA in PBMCs from 60.0% of healthy controls. These reports show that HHV-6 may establish latency also in healthy subjects and with rather a wide prevalence range, 0% to 60.0% depending on the study population.…”

Human Herpesvirus 6 Infection as a Trigger of Multiple Sclerosis

“…20,[24][25][26] One of those studies considered mean antibody titers, 20 and another reported only that the IgG titers of MS patients were higher than those of controls without providing absolute values. 24 The remaining 7 studies were classified as lower quality (C), mostly because of a failure to define and provide details about the study patients with MS. [21][22][23]27,[29][30][31] According to the CTF classification, 18 of the 18 studies were classified as quality II-1.…”

“…[21][22][23]27,31,32 All of the IgM studies were classified as quality II-1 on the basis of the CTF criteria.…”

“…Nine studies had severe methodological issues, were classified as C quality, and found no statistically significant difference between MS patients and controls 22,23,[29][30][31][32] (Ablashi et al, 22 Friedman et al, 32 and Taus et al 23 on both CSF IgG and IgM correlations).…”

“…61 The remaining 9 studies presented significant methodological problems and were classified as C quality. 22,30,46,54,[63][64][65][66]69 All the aforementioned studies were classified as II-1 studies by the CTF classification criteria.…”