Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe

Gaëte, Stanie; Auguste, Aviane; Bhakkan, Bernard; Péruvien, Jessica; Herrmann-Storck, Cécile; Socrier, Y; Diédhiou, Abdoulaye; Deloumeaux, Jacqueline

doi:10.1186/s12885-021-07940-3

Cited by 11 publications

(9 citation statements)

References 30 publications

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“…Associations between cervical lesions and infection with HR-HPV other than genotypes 16 or 18 are also notable in the study by Gaete et al [ 29 ] on 213 samples of cervical pathology with a diagnosis of dysplasia or cancer in which 31 is found to be the number one genotype at 47%, followed by genotypes 33 , 16 , 44 , and 28 .…”

Section: Discussionmentioning

confidence: 80%

High-risk HPV prevalence and vaccination coverage among Indigenous women in the Colombian Amazon: Implications for cervical cancer prevention. Cross-sectional study

Sarmiento-Medina,

de Amaya,

Villamizar-Gómez

et al. 2024

PLoS ONE

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Cervical cancer, primarily caused by Human Papillomavirus (HPV) transmission through sexual contact, necessitates comprehensive strategies to combat its impact on women’s health. Yet, certain underserved populations, such as low socioeconomic and ethnic minority groups, encounter barriers in accessing timely interventions and early diagnosis. This cross-sectional study was conducted with the aim of assessing HPV prevalence, genotype distribution, and co-infections among 280 adult women residing in a Colombian Indigenous Reserve within the Amazon region. The research adhered to a community-centric approach that respected cultural norms, native languages, and Indigenous authorities’ permission. The study revealed an overall HPV infection prevalence of 31.1% (n = 87, 95% CI 25.7–36.8), with 22.5% (n = 63, 95% CI 17.7–27.8) of women infected by at least one high-risk HPV genotype and 15.0% (n = 42, 95% CI 11–19.7) infected by at least one LR genotype. These results align with the findings of other Colombian studies. Notable high-frequency genotypes included 16, 52, 66, 56, and 68, with the most common combinations being [66–52] and [66–58]. The study also assessed the prevalence of HPV vaccination, revealing a rate of 22.9%, lower than the national average. In vaccinated women, the prevalence of genotypes 16 and 18 was significantly reduced, as anticipated. Importantly, it was observed that 57.1% of all high-risk HPV infections could have been prevented with the use of the nonavalent vaccine. These findings underscore the critical need to enhance adherence to early cervical cancer detection and monitor positive cases to evaluate high-risk HPV persistence. Efforts should be directed toward continuing vaccination coverage against high-risk HPV 16 and 18 with the quadrivalent vaccine, while also striving to make the nonavalent vaccine accessible for inclusion in large-scale public health programs. Additionally, the study did not identify a specific pattern of co-infection. The study emphasizes the significance of adopting a locally tailored epidemiological approach to guide and promote cervical cancer prevention efforts in Indigenous communities.

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Section: Discussionmentioning

confidence: 80%

High-risk HPV prevalence and vaccination coverage among Indigenous women in the Colombian Amazon: Implications for cervical cancer prevention. Cross-sectional study

Sarmiento-Medina,

de Amaya,

Villamizar-Gómez

et al. 2024

PLoS ONE

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“…In one of our previous studies, we found that HPV detected in cervical swabs is high-risk, while low-risk HPV is mainly found in vaginal and rectal swabs, and multiple subtypes of infection are common (33). Some studies have found that HPV44 is one of the common types in tumor tissues of cervical cancer patients (51), frequently detected in human intestines (52,53). Women might not be mainly high-risk types in the early stage of HPV infection, and several low-risk types of HPV might also play an important role in early infection.…”

Section: Discussionmentioning

confidence: 83%

Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection

Dong,

Luo,

Liu

et al. 2023

Preprint

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Background Previous studies have shown that changes in the microbial community of the female urogenital tract are associated with Human papillomavirus (HPV) infection. However, research on this association was mostly focused on a single site, and there are currently few joint studies on HPV infection and multiple sites in the female urogenital tract. Methods We selected 102 healthy women from Yunnan Province as the research object, collected cervical exfoliation fluid, vaginal, urethral, and rectal swabs for microbial community analysis, and measured bacterial load, and related cytokine content. The link between HPV, microbiota, and inflammation was comprehensively evaluated using bioinformatics methods. Findings: The impact of HPV infection on the microbial composition of different parts varies. We have identified several signature bacterial genera that respond to HPV infection in several detection sites, such as Corynebacterium, Lactobacillus, Campylobacter, and Cutibacterium have been detected in multiple sites, reflecting their potential significance in cross body HPV infection responses. There was a solid microbial interaction network between the cervix, vagina, and urethra. The interrelationships between inflammatory factors and different bacterial genera might also affect the immune system's response to HPV infection. Interpretation: It might be an effective strategy to prevent and treat HPV infection by simultaneously understanding the correlation between the microbial changes in multiple parts of the female genitourinary tract and rectum and HPV infection, and controlling the microbial network related to HPV infection in different parts.

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“…In one of our previous studies, we found that HPV detected in cervical swabs is high-risk, while low-risk HPV is mainly found in vaginal and rectal swabs, and multiple subtypes of infection are common [ 38 ]. Some studies have found that HPV44 is one of the common types in tumor tissues of cervical cancer patients [ 56 ], frequently detected in human intestines [ 57 , 58 ]. Studies have shown that HPV81 is detected in the majority of women with cervical cytological abnormalities and is associated with precancerous and cancerous lesions [ 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection

Dong,

Luo,

Liu

et al. 2024

J Transl Med

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Background Previous studies have shown that changes in the microbial community of the female urogenital tract are associated with Human papillomavirus (HPV) infection. However, research on this association was mostly focused on a single site, and there are currently few joint studies on HPV infection and multiple sites in the female urogenital tract. Methods We selected 102 healthy women from Yunnan Province as the research object, collected cervical exfoliation fluid, vaginal, urethral, and rectal swabs for microbial community analysis, and measured bacterial load, and related cytokine content. The link between HPV, microbiota, and inflammation was comprehensively evaluated using bioinformatics methods. Findings The impact of HPV infection on the microbial composition of different parts varies. We have identified several signature bacterial genera that respond to HPV infection in several detection sites, such as Corynebacterium, Lactobacillus, Campylobacter, and Cutibacterium have been detected in multiple sites, reflecting their potential significance in cross body sites HPV infection responses. There was a solid microbial interaction network between the cervix, vagina, and urethra. The interrelationships between inflammatory factors and different bacterial genera might also affect the immune system's response to HPV infection. Interpretation It might be an effective strategy to prevent and treat HPV infection by simultaneously understanding the correlation between the microbial changes in multiple parts of the female urogenital tract and rectum and HPV infection, and controlling the microbial network related to HPV infection in different parts.

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Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe

Cited by 11 publications

References 30 publications

High-risk HPV prevalence and vaccination coverage among Indigenous women in the Colombian Amazon: Implications for cervical cancer prevention. Cross-sectional study

High-risk HPV prevalence and vaccination coverage among Indigenous women in the Colombian Amazon: Implications for cervical cancer prevention. Cross-sectional study

Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection

Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection

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