Frequent <i>human parvovirus <scp>B19</scp></i><scp>DNA</scp> occurrence and high seroprevalence in haemophilic patients from a non‐metropolitan blood centre, Brazil

Slavov, Svetoslav Nanev; Kashima, Simone; Rocha–Junior, Maurício Cristiano; Oliveira, Léa Campos de; Silva-Pinto, Ana Cristina; Yamamoto, Aparecida Yulie; Covas, Dimas Tadeu

doi:10.1111/tme.12113

Cited by 9 publications

(6 citation statements)

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“…The virus can also be transmitted via blood or pooled-blood products, from a pregnant mother to her fetus, and possibly even from tattooing (230). Higher seroprevalences than those among controls have been detected among patients receiving blood products and women having experienced abortions but not in people with tattoos (218,231,232).…”

Section: Epidemiology Virus Prevalence and Transmissionmentioning

confidence: 99%

“…The timing of viremia before rash symptoms, high viral load, persistence, and resistance of this nonenveloped virus to most virus inactivation procedures used in the manufacturing of blood products create a risk of transmission through blood or blood products such as plasma, blood cells, and clotting factors (251)(252)(253)(254)(255)(256)(257)(258)(259)(260)(261)(262)(263)(264) as well as through bone marrow and solid-organ transplantations (265)(266)(267)(268)(269)(270). Comparisons of subjects with and those without blood transfusions have revealed a significantly higher seropositivity rate in individuals who have received blood transfusions (218,231). Even if symptomatic transfusion-transmitted B19V infections are generally rare (259,271), among eight patients with transfusion-transmitted B19V infection, five became ill with anemia, pure red blood cell aplasia (PRCA), or pancytopenia, all of whom had an underlying hematological disorder, whereas recipients without such disorders exhibited only moderate symptoms (264).…”

Section: Epidemiology Virus Prevalence and Transmissionmentioning

confidence: 99%

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Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Section: Epidemiology Virus Prevalence and Transmissionmentioning

confidence: 99%

Section: Epidemiology Virus Prevalence and Transmissionmentioning

confidence: 99%

Human Parvoviruses

2017

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“…A similar work in South Africa revealed an 8% prevalence of B19V infection among 26 patients with hemophilia [ 8 ], which is a lower rate than that of the current study; however, the sample size in the South African study was very small. Slavov in Brazil demonstrated that active infection of B19V was as high as 35.7% among 28 patients [ 25 ]. This difference in reported rates of B19V viremia may be partly related to sample size and also to other risk factors in some populations, such as coinfection with HCV, which was 10.7% in the study by Slavov.…”

Section: Discussionmentioning

confidence: 99%

Human parvovirus B19 and parvovirus 4 among Iranian patients with hemophilia

et al. 2017

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BackgroundHuman parvovirus B19 (B19V) is one of the smallest DNA viruses and shows great resistance to most disinfectants. Therefore, it is one of the common contaminant pathogens present in blood and plasma products. Parvovirus 4 (PARV4) is a newly identified parvovirus, which is also prevalent in parenteral transmission. In this study, we aimed to evaluate the prevalence of B19V and PARV4 DNA among patients with hemophilia in Birjand County in eastern Iran.MethodsThis was a cross-sectional epidemiological study comprising nearly all people with hemophilia in this region. Whole blood samples were taken after patient registration and sent for plasma isolation. After nucleic acid extraction, B19V was detected with real-time polymerase chain reaction, PARV4 DNA was then detected using sensitive semi-nested PCR.ResultsIn total, there were 86 patients with hemophilia, with mean age 28.5±1.5 years. Of these, 90.7% were men and 9.3% women; 84.9% had hemophilia A and 7.0% had hemophilia B. We found 11 patients (12.8%) were positive for B19V DNA and 8 were positive (9.3%) for PARV4 DNA. The prevalence of B19V was higher in middle-aged groups rather than younger people, whereas PARV4 infection was more common in younger patients (P <0.05).ConclusionThere was a high prevalence of B19V and PARV4 infection in this high-risk group of patients with hemophilia. Due to the clinical significance of the B19 virus, imposing more precautionary measures for serum and blood products is recommended.

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“…B19V DNA prevalence varying from 0.2 to 1.9% has been reported among blood donors, and the concentrations determined are frequently <10 4 viral genome UI/ml [18,19]. However, individuals with higher viral loads have also been detected [2,19,20,21,22,23].…”

Section: Introductionmentioning

confidence: 99%

Human parvovirus B19 frequency among blood donors after an epidemic outbreak: relevance of the epidemiological scenario for transfusion medicine

Adamo

Blanco

Viale

et al. 2020

Heliyon

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A retrospective, cross-sectional study was conducted to determine the frequency of human parvovirus B19 (B19V) infected individuals, viral loads and immunity among blood donors from Argentina, in a post-epidemic outbreak period. B19V DNA and specific IgG were tested in minimum study samples of donors attending a blood bank at C ordoba, Argentina, in 2014. Anti-B19V IgM and viral loads were determined in B19V-positive plasma samples. Seven of 731 samples (0.96%) resulted positive, corresponding to individuals aged 32-53 years, four of them repeat donnors and three first-time donors. Viral loads were <10 3 IU/mL. None had IgM and 6/7 had IgG, one of them at a high level (in the range of 100-200 IU/ml, and the remaining 5 at low to medium level, 5-50 IU/ml). Thus one case was classified as acute infection (DNAþ/IgM-/IgG-) and six as potentially persistent infections (DNAþ/IgM-/IgGþ). No coinfections with other pathogens of mandatory control in the pre-transfusion screening were detected. Prevalence of IgG was 77.9% (279/358). This study provides the first data of B19V prevalence in blood donors in Argentina, demonstrating high rates of acute and persistent B19V infections and high prevalence of anti-B19V IgG in a post-epidemic period. Further research is needed to elucidate mechanisms/factors for B19V persistence as well as follow-up of recipients in the context of haemo-surveillance programs, contributing to the knowledge of B19V and blood transfusion safety.

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Frequent human parvovirus B19DNA occurrence and high seroprevalence in haemophilic patients from a non‐metropolitan blood centre, Brazil

Cited by 9 publications

References 8 publications

Human Parvoviruses

Human Parvoviruses

Human parvovirus B19 and parvovirus 4 among Iranian patients with hemophilia

Human parvovirus B19 frequency among blood donors after an epidemic outbreak: relevance of the epidemiological scenario for transfusion medicine

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