Frequent Presence of Helicobacter pylori Infection in Chronic Urticaria

Radenhausen, Jörg-Dieter Sc Michael

doi:10.1080/000155500750012522

Cited by 11 publications

(3 citation statements)

References 10 publications

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“…9,11,15,16,37,40-43 As we also found, accompanying CIndU rates were comparable between these two groups. 11 Infection with HP has been reported to be associated with a chronic increase in circulating inflammatory markers, especially CRP, which was also higher in HP-positive patients in our study compared to HP-negative patients. 44 In previously published studies, CU disease activity was evaluated with UAS.…”

Section: Discussionsupporting

confidence: 52%

“…42,48 This result can be explained by the fact that the HP infection is mainly associated with low socioeconomic status and poor hygiene conditions, whereas high hygiene standards are a risk factor for the development of allergic conditions.49 However, in our study, there was no difference between the two groups regarding atopic disorders or total IgE elevation, the latter of which was found to be similar in another study. 11 Autoimmune CSU (type 2b autoimmunity) is one of the most prevalent CSU endotypes and is characterized by circulating autoantibodies against IgE (IgG anti-IgE) and/or the α subunit of the high-affinity IgE receptor (IgG anti-FcɛRI).50 Autoimmune CSU is frequently associated with other autoimmune disorders, elevated anti-TPO levels, and lower total IgE levels. 50, 51 The present clinical assessment of patients exhibiting autoimmune antibodies involves the use of ASST.…”

Section: Discussionmentioning

confidence: 99%

“…1, 7 Multiple studies have found a positive link between the presence of HP and the development of CU, and the commencement of HP eradication therapy has been shown to be beneficial in reducing symptoms in certain patients. [8][9][10][11][12][13] On the other hand, a number of additional studies have been unable to establish a statistically significant correlation between HP infection and CSU, and the complete eradication of HP has not consistently resulted in the resolution of CSU in all individuals. [14][15][16] Also, a recent meta-analysis reported that CSU patients who received antibiotic therapy for the eradication of HP demonstrated a notably higher rate of CSU remission, regardless of whether HP eradication was achieved or not.…”

Section: Introductionmentioning

confidence: 99%

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Reappraisal of the role of Helicobacter pylori in chronic spontaneous urticaria

ÖRNEK ÖZDEMİR,

ÖZGÜR

2023

J Health Sci Med / JHSM

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Aims: Chronic spontaneous urticaria (CSU) is one of the most prevalent skin disorders. Helicobacter pylori (HP) infection has been linked to CSU, and HP eradication therapy has been questioned as a viable treatment option. However, studies have produced contradictory results. In addition, recent studies suggest that gastritis, rather than HP bacteria, may be responsible for CSU symptoms. Herein, we aimed to ascertain the prevalence of HP infection in CSU, explore associations between HP infection, gastritis, and CSU severity or treatment response in CSU, and investigate the impact of HP eradication therapy on the CSU course. Methods: We retrospectively analyzed CSU patients who were investigated for HP infection. Patient characteristics, in-clinic urticaria activity scores (ic-UAS) and urticaria control test (UCT) scores, and CSU treatment responses were compared across different patient groups. Results: The study included 325 CSU patients, of whom 57.2% were HP-positive and 60.9% had gastritis. The mean baseline ic-UAS showed no difference between HP-positive and HP-negative patients (2.55±2 vs 2.45±1.98, p>0.05) or between patients with and without gastritis (2.33±2 vs 2.51±2, p>0.05). HP-positive patients had higher rates of elevated CRP levels (45% vs 29.9%, p=0.023) and ASST positivity (54.8% vs 29.8%, p0.05). Conclusion: Over half of CSU patients have been found to be infected with HP. However, the HP bacterium itself, the eradication of HP, or gastritis have no significant effect on CSU severity or treatment response.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reappraisal of the role of Helicobacter pylori in chronic spontaneous urticaria

ÖRNEK ÖZDEMİR,

ÖZGÜR

2023

J Health Sci Med / JHSM

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Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria

Mini¹,

Figura²,

D’Ambrosio³

et al. 2005

Proteomics

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Rosacea and chronic urticaria are two common skin disorders existing in idiopathic forms. A role of Helicobacter pylori bacterium infection in the aetiopathogenesis of rosacea or chronic urticaria has been suggested although still controversial. The aim of the present study was to establish a relationship between H. pylori infection and rosacea chronic urticaria by means of an immunoproteomic investigation. We analyzed immunoglobulin A (IgA)-, IgG-, and IgE-mediated immune-responses against H. pylori antigens and we identified some bacterial immunoresponsive proteins. A general IgA- and IgE-mediated immune response against antioxidative bacterial proteins was observed. A correlation between the bacterial occurrence and skin diseases pathogenesis is discussed.

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Dermatologische Perspektiven im 21. Jahrhundert

Orfanos

2002

Hautarzt

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During the last decades dermatology has been profoundly transformed from its descriptive origin into an important part of modern medicine and biosciences. Areas of interest and expertise in the future will likely be focused on major topics on clinical dermatology (psoriasis, atopic dermatitis, skin infections including those sexually transmitted), dermatologic oncology (squamous cell carcinoma, malignant melanoma), gene technology in biopharmacy and dermatopharmacology, and also the areas dealing with the aging of the skin and its appendages (dermatologic endocrinology, cosmetic dermatology). Increasing knowledge in dermatology is not only relevant for treating skin disease but also for helping our patients to maintain healthy and appealing skin, thus improving their requirements for beautification and their quality of life. While this is an important aim, it should not become our main task. Overall, the perspectives for dermatology are promising; in the end, its further development will depend on how modern societies will recognize its significance and reward its efforts.

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Frequent Presence of Helicobacter pylori Infection in Chronic Urticaria

Cited by 11 publications

References 10 publications

Reappraisal of the role of Helicobacter pylori in chronic spontaneous urticaria

Reappraisal of the role of Helicobacter pylori in chronic spontaneous urticaria

Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria

Dermatologische Perspektiven im 21. Jahrhundert

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