“…The majority of the studies (n = 25) did not clarify their methods of blinding. Selection bias was mainly unclear or low within and across studies, with 13 studies not specifying the method of sequence generation in randomization (29,31,32,34,36,40,42,44,45,47,53,54) and only seven studies reporting allocation concealment methods (27,28,33,38,41,43,46,50,51,59). Only seven studies reported results of pre-specified outcomes (27,28,33,39,41,43,46,50,51,59), whilst the remaining were classified as unclear as they did not publish their protocol or provide details of their trial registration.…”