Frequent Sugar-Sweetened Beverage Consumption and the Onset of Cardiometabolic Diseases: Cause for Concern?

Deshpande, Gaurang; Mapanga, Rudo F.; Essop, M. Faadiel

doi:10.1210/js.2017-00262

Cited by 50 publications

(33 citation statements)

References 65 publications

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“…The South African Adult PURE cohort study showed an association between higher consumption of added sugars and sucrose-sweetened beverages with increased non-communicable disease risk factors [69]. The role of SSBs in driving obesity and its associated complications has been supported in a recent review [70]. A lack of association between bread intake and BMI observed in this study is not congruent with other studies [47,71].…”

Section: Discussioncontrasting

confidence: 71%

Determinants of body mass index by gender in the Dikgale Health and Demographic Surveillance System site, South Africa

Mashinya

Alberts

Cook

et al. 2018

Global Health Action

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Background: The study was conducted in the Dikgale Health and Demographic Surveillance System (DHDSS) site where we have observed increasing obesity levels, particularly in women, despite evidence of high physical activity (PA) and a relatively low daily energy intake. Objective: This study aimed to assess the socio-demographic, behavioural and biological determinants of body mass index (BMI) in adult residents permanently residing in the DHDSS. Methods: A cross-sectional study was conducted in which socio-demographic, behavioural and biological characteristics from 1143 participants (aged 40–60 years) were collected using a paper questionnaire and standard anthropometric measures. Human immunodeficiency virus (HIV) testing was performed on all participants except those who indicated that they had tested positive. Chi-square and Mann-Whitney tests were used to analyze categorical and continuous variables, respectively, while hierarchical multivariate regression was used to analyze predictors of BMI. Results: The median age of women and men was 51 (46–56) and 50 (45–55) years, respectively. The prevalence of overweight-obesity was 76% in women and 21% in men. A significant negative association of BMI with HIV and smoking and a significant positive association with socio-economic status (SES) was observed in both sexes. In women, BMI was negatively associated with sleep duration (p = 0.015) and age (p = 0.012), but positively associated with sugar-sweetened beverages (SSBs) (p = 0.08). In men, BMI was negatively associated with alcohol use (p = 0.016) and positively associated with being married (p < 0.001). PA was not associated with BMI in either sexes. Full models explained 9.2% and 20% of the variance in BMI in women and men, respectively. Conclusion: BMI in DHDSS adults is not associated with physical inactivity but is associated wealth, marital status, sleep, smoking, alcohol use, and HIV status. Future studies should explore the contribution of nutrition, stunting, psycho-social and genetic factors to overweight and obesity in DHDSS.

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Section: Discussioncontrasting

confidence: 71%

Determinants of body mass index by gender in the Dikgale Health and Demographic Surveillance System site, South Africa

Mashinya

Alberts

Cook

et al. 2018

Global Health Action

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“…24,25 Directly targeting SSB consumption in the clinical setting may have the potential to impact the prevention of cardiometabolic disease. 26 In a rural practice with higher numbers of children, given the higher risk of obesity, identification of SSB consumption and targeted interventions may be even more imperative.…”

Section: Discussionmentioning

confidence: 99%

Sugar-Sweetened Beverage Intake in a Rural Family Medicine Clinic

2019

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Background: Sugar-sweetened beverages (SSBs) are a major source of calories, and are associated with adverse health outcomes. Because the majority of studies are undertaken in urban areas, the rural intake of SSB presents a significant gap in current knowledge. The objective of our study was to assess SSB intake in a rural primary care clinic. Methods: The Beverage Intake Questionnaire is a 15-item self-reported questionnaire and has been extensively validated to assess habitual SSB consumption. The survey was administered to adult primary care clinic patients presenting for routine care over a 6-week period at a clinic in a rural central Nebraska community (population < 1,000). Results: Survey participants (n ‫؍‬ 121) were primarily white with an average age of 61 years (SD ‫؍‬ 18.0) and an average body mass index (BMI) of 29.9 kg/m 2 (SD ‫؍‬ 7.5). Participants consumed an average of 1.05 SSBs per day (SD ‫؍‬ 1.3), and 33.5% of respondents consumed one or more SSBs per day. The average daily caloric intake from SSBs was 153 Kilocalories (Kcals) compared the national average intake of 145 Kcals. The most commonly consumed caloric beverages, based on Kilocalories consumed, were 100% juice and regular soda. SSB consumption was not related to with BMI. Discussion: In a rural primary care clinic, the daily consumption of SSB by patients was found to be a noteworthy source of calories, with no significant difference in consumption across BMI categories. Mitigation of SSB consumption by rural primary care clinicians is imperative for optimizing health.

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“…Moreover, their prevalence rapidly increased over the past few decades and they continue to rise, especially in low-and middle-income countries. Here, excess sugar-sweetened beverage (SSB) intake is emerging as a crucial mediator of such pathology [2] as it is linked with hyperglycemia, dyslipidemia, hyperinsulinemia, and weight gain [3,4]. In support, increased SSB intake is associated with suboptimal lifestyle choices (reduced physical activity, poor dietary choices) [5] and the development of insulin resistance and T2DM [6,7].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Sugar-Sweetened Beverage Consumption on the Liver: A Proteomics-Based Analysis

et al. 2020

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Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this study aimed to obtain greater mechanistic insights. Male Wistar rats (~200 g) were gavaged with a local SSB every day for a period of six months while the control group was gavaged with an iso-volumetric amount of water. Experimental dosages were calculated according to the surface area-to-volume ratio and were equivalent to 125 mL/day (in human terms). A proteomic analysis was performed on isolated liver samples and thereafter, markers of endoplasmic reticulum (ER) stress, antioxidant/oxidant capacity, calcium regulation, and mitochondrial functionality were assessed. These data show that SSB consumption resulted in (a) the induction of mild hepatic ER stress; (b) altered hepatic mitochondrial dynamics; and (c) perturbed calcium handling across mitochondria-associated ER membranes. Despite significant changes in markers of ER stress, the antioxidant response and calcium handling (proteomics data), the liver is able to initiate adaptive responses to counteract such stressors. However, the mitochondrial data showed increased fission and decreased fusion that may put the organism at risk for developing insulin resistance and T2DM in the longer term.

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Frequent Sugar-Sweetened Beverage Consumption and the Onset of Cardiometabolic Diseases: Cause for Concern?

Cited by 50 publications

References 65 publications

Determinants of body mass index by gender in the Dikgale Health and Demographic Surveillance System site, South Africa

Determinants of body mass index by gender in the Dikgale Health and Demographic Surveillance System site, South Africa

Sugar-Sweetened Beverage Intake in a Rural Family Medicine Clinic

The Impact of Sugar-Sweetened Beverage Consumption on the Liver: A Proteomics-Based Analysis

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