1995
DOI: 10.1002/j.1460-2075.1995.tb07111.x
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Frequent use of the same tertiary motif by self-folding RNAs.

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Cited by 339 publications
(376 citation statements)
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“…This lag was not observed with the parent ligase (13). A similar phenomenon was encountered with the Group II intron and was attributed to a Mg 2+ -induced conformation change (14). Rates were determined using the part of the curve that best fit eq 1.…”
Section: Methodsmentioning
confidence: 57%
“…This lag was not observed with the parent ligase (13). A similar phenomenon was encountered with the Group II intron and was attributed to a Mg 2+ -induced conformation change (14). Rates were determined using the part of the curve that best fit eq 1.…”
Section: Methodsmentioning
confidence: 57%
“…Additionally, a GAAA tetraloop in P5abc docks into its tetraloop receptor by both cross-helical base stacking and extensive hydrogen bonding. Similar GAAA tetraloop/tetraloop receptor interactions are thought to occur in other large RNAs including group I and group II introns and ribosomal RNA (5). Thus, the P4-P6 domain crystal structure provides a basis for examining the formation and stability of tertiary interactions that characterize helix packing in RNA.…”
mentioning
confidence: 75%
“…The tetraloop/tetraloop receptor motif is perhaps the most famous RNA motif. It was first identified by phylogeny in group I and II introns by Michel, Westhof, and colleagues and observed for the first time in the seminal crystal structure of the P4-P6 domain of the Tetrahymena group I intron, in which this motif reinforces the side-by-side packing architecture of RNA helices [84][85][86]. This motif and others are ubiquitous in the ribosome and other structured RNAs [87][88][89][90][91].…”
Section: Simple Forces Underlying the Complex Behavior Of Rnamentioning
confidence: 99%