Frequently subnormal semen profiles of normal volunteers recruited over 17 years

Lemcke, B.; Behre, Hermann M.; Nieschlag, Eberhard

doi:10.1046/j.1365-2605.1997.00045.x

Cited by 44 publications

(30 citation statements)

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“…Whereas several studies reported an agedependent decrease in the sperm concentration [7,[21][22][23][24][25], others were not able to confirm such findings [9,20,26,27]. In the present study, the sperm concentration was found to be significantly higher in group IV than in groups II and III and significantly higher in group I than in group II.…”

Section: Discussioncontrasting

confidence: 87%

“…In fact, motility was reported to decrease by 0.7% per year of age [21]. Several studies reported a significant decrease in the sperm motility with advancing age [16,23,[25][26][27], whereas others found an increase in the sperm motility with age [31,32]. Several studies on infertile groups, however, revealed no significant evidence of deteriorating sperm motility with advancing age [33,34].…”

Section: Discussionmentioning

confidence: 99%

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The possible effect of age on sperm velocities and morphological defects

El-Garem¹,

Eid²

2014

Human Andrology

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PurposeTo investigate the effect of age on sperm velocities and morphology in a sample of Egyptian males. Patients and methodsIn a prospective study, 634 healthy Egyptian volunteers were divided according to their age into four groups: group I, aged 20-29 years (n = 205); group II, aged 30-39 years (n = 213); group III, aged 40-49 years (n = 124); and group IV, aged 50-59 years (n = 92). Semen samples were collected and analyzed according to the WHO 2010 criteria. For each age group, the sperm volume, the concentration, the progressive and total motility, the sperm morphology, the teratozoospermia index, the curvilinear velocity (VCL), the straight-line velocity (VSL), the average path velocity (VAP), and the linearity were determined. Serum levels of reproductive hormones were also determined. ResultsThe study revealed a significant decrease in the sperm motility (Po0.001), the progressive motility (Po0.001), the morphology (P = 0.003), sperm velocities (VCL, VSL, VAP) (Po0.001), and linearity (Po0.001) in older age groups compared with younger age groups. There was a significant negative correlation between the age and the semen volume (Po0.001), the progressive motility (P = 0.001), the percent of morphologically normal sperms (P = 0.023), VCL (Po0.001), VSL (P = 0.003), and VAP (P = 0.002). We also detected a significant correlation between the age and the presence of coiled tails (Po0.001) and tails with smooth hairpin bends (P = 0.023) and a sharply bent neck (P = 0.015). Age was not found to negatively influence sperm head abnormalities. Conclusion It is possible that advancing age negatively influences the semen volume and the sperm morphology, motility, and velocities, which may be reflected in the reproductive potential of aging men.

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

The possible effect of age on sperm velocities and morphological defects

El-Garem¹,

Eid²

2014

Human Andrology

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“…In contrast, other studies have illustrated an increase in concentration of 0.3%-3.3% per year of age [24][25][26][27] while another subset of reports details no association with paternal age. 14,18,28,29 The difficulty in analyzing concentration data, however, is the concomitant change in semen volume that may occur with APA.…”

Section: Effect Of Paternal Age On Semen Qualitymentioning

confidence: 99%

The effects of advanced paternal age on fertility

Kovac¹,

Addai²,

Smith³

et al. 2013

Asian J Androl

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Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.

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“…[8][9][10][11] On the other hand, fertile men may also be investigated for infertility and subsequently treated as a result of their low semen quality. 12,13 To establish evidence-based reference values, the WHO 2010 manual describes the values obtained in eight countries from 1953 men who became fathers with a time to pregnancy of less than 12 months. Therefore, this is a population of fertile men whose spouses were of high or normal fecundity and who established a pregnancy in f12 months.…”

Section: The Semen Analysis (Who 2010)mentioning

confidence: 99%

Semen analysis and sperm function testing

Franken¹,

Oehninger²

2011

Asian J Androl

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Despite controversy regarding the clinical value of semen analysis, male fertility investigation still relies on a standardized analysis of the semen parameters. This is especially true for infertility clinics in both developing and developed countries. Other optional tests or sophisticated technologies have not been widely applied. The current review addresses important changes in the analysis of semen as described in the new World Health Organization (WHO) manual for semen analysis. The most important change in the manual is the use of evidence-based publications as references to determine cutoff values for normality. Apart from the above mentioned changes, the initial evaluation and handling methods remain, in most instances, the same as in previous editions. Furthermore, the review evaluates the importance of quality control in andrology with emphasis on the evaluation of sperm morphology. WHO sperm morphology training programmes for Sub-Saharan countries were initiated at Tygerberg Hospital in 1995. The external quality control programme has ensured that the majority of participants have maintained their morphological reading skills acquired during initial training. This review reports on current sperm functional tests, such as the induced acrosome reaction, and sperm-zona pellucida binding assays, as well as the impact of sperm quality in terms of DNA integrity, and the relationship of sperm function tests to sperm morphology.

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Frequently subnormal semen profiles of normal volunteers recruited over 17 years

Cited by 44 publications

References 0 publications

The possible effect of age on sperm velocities and morphological defects

The possible effect of age on sperm velocities and morphological defects

The effects of advanced paternal age on fertility

Semen analysis and sperm function testing

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