Lightweight concrete (LWC) has been used successfully in building constructions for many years due to its physical properties and its lightweight with high thermal insulation and durability. Recently, this work was done on a new type of concrete: lightweight self-compacting concrete (LWSCC) that combines the feature of lightweight and self-compacting concrete simultaneously. In this study, light expanded clay aggregate (LECA) was used as coarse aggregate in (LWSCC) mixtures, using nano-silica as a partial replacement of cement with three percent (0.5, 0.75, and 1%) by mass of cement. They were tested to evaluate these values of fresh characteristics through slump flow time and diameter, L-box, and segregation tests. The results of the fresh concrete tests showed a decrease in the workability of the concrete in the mixtures containing nano-silica due to the increase in fine materials in the mixture. The effects of nano-silica on the hardened properties of (LWSCC) such as compressive strength, flexural strength, splitting tensile strength, oven-dry density, and scanning electron microscopy (SEM), have improved. The mixtures containing nano-silica were investigated and compared with the reference mixture, where the results of the tests showed a significant improvement in the mechanical properties by (17.35, 16.27, 11.73, and 3.82%) for each of the compressive strength, flexural strength, splitting tensile strength and oven dry density respectively. In the presence of nano-silica, the replacement percentage of 1% recorded the best results in all tests at 90 days of curing.