Fresh Frozen Plasma Contains Viable Progenitor Cells – Should We Irradiate?

Bernvil, S.S.; Abdulatiff, M.; Al‐Sedairy, Sultan T.; Sasich, F.; Sheth, Kirtikant V.

doi:10.1111/j.1423-0410.1994.tb01283.x

Cited by 27 publications

(2 citation statements)

References 3 publications

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“…However, several studies have shown significant numbers of WBCs contaminating plasma units (1 ¥ 10 6 -3 ¥ 10 6 WBCs per unit) before freeze, although only a small percentage of viable WBCs remain after the freeze-thaw process. [136][137][138][139] Destruction of WBCs during freeze-thaw can release bioactive mediators which may mediate FNHTR. 140 In 2010, the rate of FNHTRs reported to SHOT for plasma was 0.9 per 100,000 units.…”

Section: Wbc-associated Risksmentioning

confidence: 99%

Adverse effects of plasma transfusion

Pandey¹,

Vyas²

2012

Transfusion

303

251

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Plasma utilization has increased over the last two decades, and there is a growing concern that many plasma transfusions are inappropriate. Plasma transfusion is not without risk, and certain complications are more likely with plasma than other blood components. Clinical and laboratory investigations of the patients suffering reactions following infusion of fresh frozen plasma (FFP) define the etiology and pathogenesis of the panoply of adverse effects. We review here the pathogenesis, diagnosis, and management of the risks associated with plasma transfusion. Risks commonly associated with FFP include: (1) transfusion related acute lung injury; (2) transfusion associated circulatory overload, and (3) allergic/anaphylactic reactions. Other less common risks include (1) transmission of infections, (2) febrile non-hemolytic transfusion reactions, (3) RBC allo-immunization, and (4) hemolytic transfusion reactions. The affect of pathogen inactivation/reduction methods on these risks are also discussed. Fortunately, a majority of the adverse effects are not lethal and are adequately treated in clinical practice.

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Section: Wbc-associated Risksmentioning

confidence: 99%

Adverse effects of plasma transfusion

Pandey¹,

Vyas²

2012

Transfusion

303

251

View full text Add to dashboard Cite

show abstract

“…Despite freezing and thawing, fresh-frozen plasma (FFP) contains substantial numbers of intact and viable cells, some of which are still able to proliferate [2,[7][8][9]. The demonstration of viable WBC in thawed FFP has prompted some institutions to irradiate FFP to avoid transfusion-associated graft versus host disease (GvHD) in immunocompromised patients [10].…”

Section: Introductionmentioning

confidence: 99%