2013
DOI: 10.1111/jth.12351
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Fresh frozen plasma: the most commonly prescribed hemostatic agent

Abstract: Summary Although fresh frozen plasma (FFP) is one of the most commonly prescribed therapies in clinical practice throughout the world today, there is little medical evidence available supporting its use. Recent guidelines have called for limiting FFP transfusions. Despite this, FFP use does not seem to be decreasing. The reasons for this are likely to be multifactorial, and may be based on ideas regarding medical practices dating back to Galen and Hippocrates. A review of the history of the development of FFP … Show more

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Cited by 34 publications
(35 citation statements)
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“…We differ with Blatt and White's assessment that the (A)PTT with kaolin developed by Proctor and Rapaport [3] was a simple refinement of the PTT test published by Langdell et al [4]. The (A)PTT test developed by Proctor and Rapaport was significantly different from that of the PTT test of Langdell et al [4].…”
contrasting
confidence: 77%
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“…We differ with Blatt and White's assessment that the (A)PTT with kaolin developed by Proctor and Rapaport [3] was a simple refinement of the PTT test published by Langdell et al [4]. The (A)PTT test developed by Proctor and Rapaport was significantly different from that of the PTT test of Langdell et al [4].…”
contrasting
confidence: 77%
“…The (A)PTT test developed by Proctor and Rapaport was significantly different from that of the PTT test of Langdell et al [4]. The latter showed that while high concentrations of crude tissue extracts clotted normal and hemophilic plasmas with the same clotting times, tissue extracts diluted 100 to 1000 times or more consistently clotted the normal plasma more rapidly than the hemophilic plasma.…”
mentioning
confidence: 86%
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