Fresh Osteochondral Allograft Transplantation in Osteochondritis Dissecans in the Knee Joint

Sarsisa, Tommaso Roberti Di; Fiore, Michele; Coco, V.; Govoni, Marco; Vivarelli, Leonardo; Rani, Nicola; Piccolo, Nicolandrea Del

doi:10.3390/life11111205

Cited by 13 publications

(11 citation statements)

References 78 publications

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“… 70 , 71 Patient-reported outcomes in this cohort are similar to the general OCA population in that knee outcome scores, such as Knee Injury and Osteoarthritis Outcome Score and IKDC, all improve postoperatively. 72 Importantly, satisfaction in this treatment group is generally high, with recent studies reporting average satisfaction rates ranging from 81% to 95%. 70 , 71 While the early data supporting OCA for the treatment of OCD are promising, studies examining longer term survival in this population are needed since the average age of patients in some studies undergoing OCA transplantations for OCD is just 23.9 years.…”

Section: Graft Survivorship and Patient Outcomesmentioning

confidence: 86%

Section: Graft Survivorship and Patient Outcomesmentioning

confidence: 99%

“…70,71 While the early data supporting OCA for the treatment of OCD are promising, studies examining longer term survival in this population are needed since the average age of patients in some studies undergoing OCA transplantations for OCD is just 23.9 years. 72 Current methods for cartilage repair other than OCA include subchondral marrow stimulation, ACI, and OAT. When these procedures fail, OCA has been shown to be an acceptable salvage procedure, with 91% graft survival at 3.5 years, 82% at 10 years, and 74.9% at 15 years for salvage cases.…”

Section: Graft Survivorship and Patient Outcomesmentioning

confidence: 99%

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Osteochondral Allografts in Knee Surgery: Narrative Review of Evidence to Date

Lai¹,

Bohlen²,

Fackler³

et al. 2022

ORR

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Knee articular cartilage defects can result in significant pain and loss of function in active patients. Osteochondral allograft (OCA) transplantation offers a single-stage solution to address large chondral and osteochondral defects by resurfacing focal cartilage defects with mature hyaline cartilage. To date, OCA transplantation of the knee has demonstrated excellent clinical outcomes and long-term survivorship. However, significant variability still exists among clinicians with regard to parameters for graft acceptance, surgical technique, and rehabilitation. Technologies to optimize graft viability during storage, improve osseous integration of the allograft, and shorten recovery timelines after surgery continue to evolve. The purpose of this review is to examine the latest evidence on treatment indications, graft storage and surgical technique, patient outcomes and survivorship, and rehabilitation after surgery.

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Section: Graft Survivorship and Patient Outcomesmentioning

confidence: 86%

Section: Graft Survivorship and Patient Outcomesmentioning

confidence: 99%

Section: Graft Survivorship and Patient Outcomesmentioning

confidence: 99%

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Osteochondral Allografts in Knee Surgery: Narrative Review of Evidence to Date

Lai¹,

Bohlen²,

Fackler³

et al. 2022

ORR

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“…When refixation is not possible along with fragment removal, other techniques such as microfracture of the subchondral bone (MF) and autologous chondrocyte implantation (ACI) can also be used [ 18 , 19 ]. The microfracture of the subchondral bone is made in order to harvest bone marrow mesenchymal stem cells to reconstruct the cartilage defect.…”

Section: General Presentation Of the Knee Osteochondral Fracturesmentioning

confidence: 99%

Treatment of Knee Osteochondral Fractures

et al. 2022

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Osteochondral lesions (OCLs) that are frequently encountered in skeletally immature and adult patients are more common than once thought, and their incidence rate is rising. These lesions can appear in many synovial joints of the body, such as the shoulder, elbow, hip, and ankle, occurring most often in the knee. The term osteochondral lesion includes a vast spectrum of pathologies such as osteochondritis dissecans, osteochondral defects, osteochondral fractures, and osteonecrosis of the subchondral bone. When considering this, the term osteochondral fracture is preserved only for an osteochondral defect that combines disruption of the articular cartilage and subchondral bone. These fractures commonly occur after sports practice and are associated with acute lateral patellar dislocations. Many of these lesions are initially diagnosed by plain radiographs; however, a computed tomography (CT) scan or magnetic resonance imaging (MRI) can add significant value to the diagnosis and treatment. Treatment methods may vary depending on the location and size of the fracture, fragment instability, and skeletal maturity. The paper reports a 14-year-old boy case with an osteochondral fracture due to sports trauma. The medical approach involved an arthrotomy of the knee, drainage of the hematoma, two Kirschner wires (K-wires) for temporary fixation to restructure anatomic alignment, and a titanium Herbert screw fixing the fracture permanently. The patient had a favorable postoperative outcome with no residual pain, adequate knee stability, and a normal range of motion. The mobility of the knee was fully recovered.

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“…The scoping review of Di Sarsina et al was aimed at analysing the clinical outcomes and failure rates of fresh osteochondral allograft transplantations (FOCA) in patients affected by Osteochondritis Dissecans (OCD) [ 15 ]. OCD affects a wide spectrum of patients, but it is most prevalent in adolescents and young adults.…”

mentioning

confidence: 99%