2016
DOI: 10.1136/annrheumdis-2016-eular.6006
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FRI0030 Anti-TNF-α Antibody Targeted To Inflamed Synovial Tissue for The Treatment of Rheumatoid Arthritis

Abstract: BackgroundTNF-α neutralizing molecules represent one of the most efficient therapeutic approaches to control inflammation in rheumatoid arthritis (RA). The widespread distribution in the body induces the inhibition of TNF-α in all the tissues, requesting the use of high dose of this expensive drug. Another problem that has not yet been solved in the management of RA patients is how to reduce and possibly avoid the side effects, particularly the increased risk of common and opportunistic infections, which may b… Show more

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“…Tumor and liver sections of 30µm were cut from frozen organs with a cryostat at -20°C, and treated as previously described (32). Slices were firstly fixed with PFA 4% for 20 min and rehydrated for 5 min with PBS at room temperature.…”
Section: Confocal Microscopy Of Tissuesmentioning
confidence: 99%
“…Tumor and liver sections of 30µm were cut from frozen organs with a cryostat at -20°C, and treated as previously described (32). Slices were firstly fixed with PFA 4% for 20 min and rehydrated for 5 min with PBS at room temperature.…”
Section: Confocal Microscopy Of Tissuesmentioning
confidence: 99%