FRI0351 Papulopustular lesions according to age, sex and localization in behcet's syndrome patients compared healthy and diseased controls

Abstract

BackgroundPapulopustular lesions (PPL) are the most common skin lesions in Behçet's syndrome (BS).ObjectivesTo assess whether PPL are different in BS according to localization, age, sex and medications used when compared to rheumatoid arthritis patients (RA) and apparently healthy subjects (HS).Methods209 consecutive BS patients who were routinely followed in our dedicated BS center were studied. Patients with RA (n=146) who were followed up in the rheumatology outpatient clinic of the same unit and HS (n=149) were used as controls. All subjects were clinically evaluated by the same dermatologist and all skin lesions (papules, pustules, comedones, folliculitis, cysts, nodules) on the face, trunk and legs were separately counted. Information regarding the demographic and clinical features of primary disease and medications used were obtained from patients' charts.ResultsSubjects without PPL were excluded before analyses. Demographic features and mean number of PPL according to site of body were summarized in Table-1. Mean number of total PPL were similar between BS and HS and significantly higher than in RA (p<0.001). Mean number of total PPL according to sex were similar in RA and HS but higher in male BS patients compared to female BS patients (p=0.04). When we analyzed the number of PPL according to different body sites, we observed that BS patients had significantly more lesions on the legs when compared to the RA patients and HS (p<0.0001). Number of PPL lesions tend to decrease as the patient ages in BS similar to RA and HS. When leg lesions were analyzed according to age, this difference remained in the age groups 31–50 and >50 but not in the age group ≤30. Corticosteroid use did not impact the results.Table 1BSRAHS N155 (74%)57 (39%)*101 (68%)F/M95/6046/1152/49Mean age (SD)38.6 (10.0)47.5 (13)†34.7 (12.0)N of pts on corticosteroids24 (15 M/9 F) (15%)37 (9 M/28F) (65%)–Mean n of PPL (SD)7.8 (8.0)3.9 (3.8)‡9.7 (9.5)Trunk107 (58F/49M) (70%)36 (28F/8M) (63%)81 (37F/44M) (80%)Face120 (80F/40M) (77%)37 (32F/5M) (65%)84 (50F/34M) (83%)Legs48 (21F/27M)§ (31%)2 (1F/1M) (3.5%)13 (5F/8M) (13%)*p<0.001, †p<0.02, ‡p<0.05, §p<0.0001.ConclusionsBS patients have significantly more PPL on the legs when compared to HS and RA. Number of PPL tend to decrease as the patient ages in BS similar to RA and HS however BS patients still have more PPL on the legs after the age of 50 suggesting that these lesions somehow differ from acne vulgaris, in pathogenesis.Disclosure of InterestNone declared