Fricke-Xylenol orange-Gelatin gel characterization with dual wavelength cone-beam optical CT scanner for applications in stereotactic and dynamic radiotherapy

Rousseau, Alice; Stien, C.; Bordy, Jean-Marc; Blidéanu, V.

doi:10.1016/j.ejmp.2022.03.008

Cited by 13 publications

(7 citation statements)

References 25 publications

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“…Moreover, the addition of the metallic-ion indicator like as Xylenol Orange (XO) 7,8 to the Fricke gel dosimeters makes these materials suitable for being analyzed by 3D-optical CT scanners. 9,10 Besides the great advantages, some limits, such as the spatial and temporal instability of the dosimetric information, make this kind of dosimeter still inadequate for routine applications in the clinical environment. Various FG dosimeters are discussed in the literature based on different polymeric matrices and readout approaches in order to overcome these limits.…”

Section: Introductionmentioning

confidence: 99%

“…A 3D spatial dose-information is achievable within the gel volume, and it can be captured and retrieved by Magnetic Resonance Imaging (MRI), , since the two iron ions influence differently the nuclear relaxation times of the protons in the molecules surrounding them. Moreover, the addition of the metallic-ion indicator like as Xylenol Orange (XO) , to the Fricke gel dosimeters makes these materials suitable for being analyzed by 3D-optical CT scanners. , …”

Section: Introductionmentioning

confidence: 99%

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Dosimetric Double Network Hydrogel Based on Poly(vinyl-alcohol)/Phenylalanine-Derivatives with Enhanced Mechanical Properties

Locarno

Gallo

Arosio

et al. 2023

ACS Appl. Polym. Mater.

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An innovative double network hydrogel based on poly(vinyl-alcohol) (PVA) cross-linked with glutaraldehyde (GTA) was obtained by the addition of self-assembling phenylalanine (Phe) derivatives with the aim to achieve improved mechanical-elastic properties exploitable to produce 3D dosimeters. The self-assembling ability in fibrous structures of Phe derivatives (FmocPhe-OH, A; FmocPhe-Phe-OMe, P) even within the PVA gel was proved by AFM and SEM imaging. The proposed matrices containing A and P were completely characterized from the physical-chemical point of view in order to deeply understand how the two molecules influenced the hydrogel properties. Mechanical tests proved that the addition of the Phe derivatives produce higher stiffness, toughness, and stretchability of the hydrogels. In particular, these properties appear in the peptide P matrix and could be appropriately tailored by regulating the concentration of the added molecule. Preliminary dosimetric studies were also performed by infusing the studied hydrogels with Fricke solution. The P type has been demonstrated to be suitable for dosimetric applications by avoiding any effect on the dose response of the hydrogel. This work presents an unconventional material that is able to provide clinicians and medical physicists with effective and reliable 3D dosimetric measurements for the development of anthropomorphic phantoms that mimic mechanical properties and the radiological response of human tissues.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dosimetric Double Network Hydrogel Based on Poly(vinyl-alcohol)/Phenylalanine-Derivatives with Enhanced Mechanical Properties

Locarno

Gallo

Arosio

et al. 2023

ACS Appl. Polym. Mater.

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“…The MDD values range between 1.12 Gy and 1.52 Gy for the batches from 1 to 3 and reach 2.31 Gy and 2.04 Gy respectively for batches 4 and 5 as the signal-to-noise ratio was higher for these ones. This method has been largely used for characterizing and comparing polymer gel dosimeters [45][46][47][48][49] and some authors also used it for Fricke gel dosimeters analysis [11,[50][51][52]. They reported D 95% D values, for low irradiation doses, smaller than those obtained with EDBreast gel (table 3).…”

Section: Dose Resolution and Minimum Detectable Dosementioning

confidence: 99%

Preliminary dosimetric characterization of EDBreast gel

Stien

Rousseau

Bordy

et al. 2023

Biomed. Phys. Eng. Express

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Purpose: EDBreast gel is an alternative Fricke gel dosimeter, read by Magnetic Resonance Imaging, in which sucrose is added to lower diffusion effects. This paper aims at determining the dosimetric characteristics of this dosimeter.Methods: The characterization has been performed in high energy photon beams. The dose-response of the gel has been evaluated as well as its detection limit, its fading effects, the reproducibility of its response and its stability over time. Its energy and dose-rate dependence has been investigated, and the overall dose uncertainty budget established. Once characterized, the dosimetry method has been applied to a simple reference irradiation case in a 6 MV photon beam, with the measurement of the lateral dose profile of a 2 x 2 cm² field. The results have been compared with microDiamond measurements.Results: In addition to its low diffusivity, the gel presents a high sensitivity, no dose-rate dependence considering TPR(20-10) values ranging from 0.66 to 0.79 and an energy response comparable to ionization chambers. However, its non-linear dose-response induces a high uncertainty on the measured dose (8 % (k=1) at 20 Gy) and reproducibility issues. The profile measurements displayed discrepancies compared to the microDiamond due to diffusion effects. The appropriate spatial resolution was estimated using the diffusion coefficient. Conclusion: EDBreast gel dosimeter presents interesting characteristics for applications in clinics, but the linearity of its dose-response should be improved to lower the uncertainties and to enhance the reproducibility.

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“…As an example, Fricke gel dosimeters utilize radiation‐induced oxidation. The products corresponding to the absorbed dose are retained in the gel matrix, and the spatial dose distribution can be obtained by examining the distribution of these products with a 3D scanner such as a magnetic resonance imager 14–16 or optical computed tomography system 17,18 …”

Section: Introductionmentioning

confidence: 99%

“…The products corresponding to the absorbed dose are retained in the gel matrix, and the spatial dose distribution can be obtained by examining the distribution of these products with a 3D scanner such as a magnetic resonance imager [14][15][16] or optical computed tomography system. 17,18 Several types of gel dosimeters have been developed for the evaluation of dose distributions in heavy-ion beam radiotherapy, but with limited success. [19][20][21][22] For example, sensitivity also decreases under proton-ion beam irradiation that is not so high LET, and necessitating a correction.…”

Section: Introductionmentioning

confidence: 99%

Radio‐fluorogenic nanoclay gel dosimeters with reduced linear energy transfer dependence for carbon‐ion beam radiotherapy

et al. 2022

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Purpose The precise assessment of the dose distribution of high linear energy transfer (LET) radiation remains a challenge, because the signal of most dosimeters will be saturated due to the high ionization density. Such measurements are particularly important for heavy‐ion beam cancer therapy. On this basis, the present work examined the high LET effect associated with three‐dimensional gel dosimetry based on radiation‐induced chemical reactions. The purpose of this study was to create an ion beam radio‐fluorogenic gel dosimeter with a reduced effect of LET. Methods Nanoclay radio‐fluorogenic gel (NC‐RFG) dosimeters were prepared, typically containing 100 μM dihydrorhodamine 123 (DHR123) and 2.0 wt% nanoclay together with catalytic additives promoting Fenton or Fenton‐like reactions. The radiological properties of NC‐RFG dosimeters having different compositions in response to a carbon‐ion beam were investigated using a fluorescence gel scanner. Results An NC‐RFG dosimeter capable of generating a fluorescence intensity distribution reflecting the carbon‐ion beam dose profile was obtained. It was clarified that the reduction of the unfavorable LET dependence results from an acceleration of the reactions between DHR123 and H2O2, which is a molecular radiolysis product. The effects of varying the preparation conditions on the radiological properties of these gels were also examined. The optimum H2O2 catalyst was determined to include 1 mM Fe3+ ions, and the addition of 100 mM pyridine was also found to increase the sensitivity. Conclusions This technique allows the first‐ever evaluation of the depth–dose profile of a carbon‐ion beam at typical therapeutic levels of several Gy without LET effect.

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Fricke-Xylenol orange-Gelatin gel characterization with dual wavelength cone-beam optical CT scanner for applications in stereotactic and dynamic radiotherapy

Cited by 13 publications

References 25 publications

Dosimetric Double Network Hydrogel Based on Poly(vinyl-alcohol)/Phenylalanine-Derivatives with Enhanced Mechanical Properties

Dosimetric Double Network Hydrogel Based on Poly(vinyl-alcohol)/Phenylalanine-Derivatives with Enhanced Mechanical Properties

Preliminary dosimetric characterization of EDBreast gel

Radio‐fluorogenic nanoclay gel dosimeters with reduced linear energy transfer dependence for carbon‐ion beam radiotherapy

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