Friction Amyloidosis: A Variant or an Etiologic Factor in Amyloidosis Cutis?

Sivakoti, Sumitra; Yesudian, Patrick

doi:10.1111/j.1365-4362.1993.tb02812.x

Cited by 20 publications

(13 citation statements)

References 9 publications

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“…It seems likely that the mechanism of pigmentation is a response to repeated damage of the basal layer of the epidermis as a result of squeezing the epidermis between the washing brush above and the bone below. Similar pigmentation has been described following chronic rubbing with nylon washing brushes in Japan (2–6), Mexico (7), India (8), and China (9).…”

Section: Discussionsupporting

confidence: 67%

Frictional Dermal Melanosis (Lifa Disease) over Bony Prominences

Sharquie

Al-Dorky

2001

The Journal of Dermatology

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Seventy-one patients (70 females and one male) were studied. Their ages at presentation ranged from 16-43 years with a mean of 24.4 years. The duration of disease varied from three months to ten years with a median of 2.7 years. All patients were slim and had recorded using a washing agent (Lifa) during bathing with vigorous friction. Family history of the same disease was present in 11 (15.5%) patients. The pigmentation was brown-black with a rippled pattern and showed no contrast under Wood's light. The areas commonly affected were clavicles (71.8%), shins (36.6%), upper back (32.4%), Adam's apple (31%), lateral aspects of the arms (31%) and other areas. The histopathology of biopsies from 24 patients showed marked dermal melanosis. Amyloid deposits in the papillary dermis were present in one patient. This clinical and histopathological picture suggests that this common condition is related to frictional melanosis.

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Section: Discussionsupporting

confidence: 67%

Frictional Dermal Melanosis (Lifa Disease) over Bony Prominences

Sharquie

Al-Dorky

2001

The Journal of Dermatology

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“…The objects causing the friction included sponges used during bathing, nylon brushes, plant sticks and leaves, and towels. The possible role of friction in the causation of cutaneous amyloidosis has been reported in several previous reports 1–5,9 . One study of three patients 1 found nylon brushes, plastic objects, towels and fingernails to be the most common objects causing friction.…”

Section: Discussionmentioning

confidence: 87%

“…Furthermore, the limitations of histochemical stains in the detection of amyloid and the usefulness of electron microscopy in the diagnosis of the condition have been recognized 1 . The role of scratching and friction in the causation of this condition has been reported in other studies 3–5 …”

Section: Introductionmentioning

confidence: 95%

Frictional amyloidosis: A study of 10 cases

et al. 2001

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Ten patients with macular amyloidosis were studied with particular reference to the role of friction. All 10 patients had a history of prolonged rubbing over a period of 2-5 years with various objects, such as bath sponges, brushes, towels, plant sticks and leaves. The presence of amyloid was confirmed by histochemical stains in six cases and by electron microscopy in four cases. The study confirms the role of friction in the causation of macular amyloidosis and hence, the term 'frictional amyloidosis' aptly describes the condition. The study also emphasizes the need for electron microscopy in the diagnosis of frictional amyloidosis.

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“…Our patient’s occupation involved bending wires with her thumb, index and middle fingers, which led us to postulate a role for chronic friction or pressure in the localization of her lesions. The role of friction in amyloidosis has previously been explored in lichen amyloidosis, 8–10 suggesting that in at least one third of cases, local friction correlated with the site of amyloid deposits. The occupations or hobbies of the previous two cases of localized acquired cutis laxa were not reported.…”

Section: Discussionmentioning

confidence: 99%

Myeloma‐associated systemic amyloidosis presenting with acquired digital cutis laxa‐like changes

et al. 2002

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A 59-year-old woman presented with a 6-year history of lax skin on the distal fingers of both hands, as well as a recent increase in the size of her tongue. Histopathology of skin from her distal finger showed amyloid deposition and bone marrow biopsy revealed an underlying plasma cell dyscrasia. Initial treatment with cyclophosphamide, vincristine, adriamycin and methylprednisolone has produced a significant reduction in the swelling of both her hands and tongue. Acquired digital cutis laxa-like changes are a rare cutaneous manifestation of systemic amyloidosis.

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Friction Amyloidosis: A Variant or an Etiologic Factor in Amyloidosis Cutis?

Abstract: The role of friction in the causation of lesions that resemble amyloidosis cutis morphologically is discussed.

Cited by 20 publications

References 9 publications

Frictional Dermal Melanosis (Lifa Disease) over Bony Prominences

Frictional Dermal Melanosis (Lifa Disease) over Bony Prominences

Frictional amyloidosis: A study of 10 cases

Myeloma‐associated systemic amyloidosis presenting with acquired digital cutis laxa‐like changes

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