Friction-limited cell motility in confluent monolayer tissue

Christensen, Amalie; West, Ann-Katrine Vrans; Wullkopf, Lena; Erler, Janine T.; Oddershede, Lene B.; Mathiesen, Joachim

doi:10.1088/1478-3975/aacedc

Cited by 8 publications

(10 citation statements)

References 50 publications

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“…The effects of RAS induction were modeled on the basis of experimental data (Materials and Methods). The model emulated the dynamics of discrete focal contact points between cells of the monolayer and the substrate matrix by means of a viscoelastic solid friction law ( 44 ). Decreased adhesion between RAS -transformed bilayers and the underlying substrate matrix (Fig.…”

Section: Resultsmentioning

confidence: 99%

OncogenicRASinstructs morphological transformation of human epithelia via differential tissue mechanics

et al. 2021

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The loss of epithelial homeostasis and the disruption of normal tissue morphology are hallmarks of tumor development. Here, we ask how the uniform activation oncogene RAS affects the morphology and tissue mechanics in a normal epithelium. We found that inducible induction of HRAS in confined epithelial monolayers on soft substrates drives a morphological transformation of a 2D monolayer into a compact 3D cell aggregate. This transformation was initiated by the loss of monolayer integrity and formation of two distinct cell layers with differential cell-cell junctions, cell-substrate adhesion, and tensional states. Computational modeling revealed how adhesion and active peripheral tension induces inherent mechanical instability in the system, which drives the 2D-to-3D morphological transformation. Consistent with this, removal of epithelial tension through the inhibition of actomyosin contractility halted the process. These findings reveal the mechanisms by which oncogene activation within an epithelium can induce mechanical instability to drive morphological tissue transformation.

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Section: Resultsmentioning

confidence: 99%

OncogenicRASinstructs morphological transformation of human epithelia via differential tissue mechanics

et al. 2021

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“…Another pending task is to link the molecular mechanisms of actin polymerization and cell-substrate adhesion with the actual self-propulsion and friction forces included in models of collective cell migration. In particular, the most appropriate type of cell-substrate friction is still unclear [172], largely due to the lack of experimental evidence.…”

Section: Discussionmentioning

confidence: 99%

Physical Models of Collective Cell Migration

Alert

Trepat

2020

Annu. Rev. Condens. Matter Phys.

307

269

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Collective cell migration is a key driver of embryonic development, wound healing, and some types of cancer invasion. Here we provide a physical perspective of the mechanisms underlying collective cell migration. We begin with a catalogue of the cell-cell and cell-substrate interactions that govern cell migration, which we classify into positional and orientational interactions. We then review the physical models that have been developed to explain how these interactions give rise to collective cellular movement. These models span the sub-cellular to the supracellular scales, and they include lattice models, phase fields models, active network models, particle models, and continuum models. For each type of model, we discuss its formulation, its limitations, and the main emergent phenomena that it has successfully explained. These phenomena include flocking and fluid-solid transitions, as well as wetting, fingering, and mechanical waves in spreading epithelial monolayers. We close by outlining remaining challenges and future directions in the physics of collective cell migration.

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“…Friction in tendon repair was shown equally important [515]. Tribology at cellular levels: The effect of friction on cell behaviors was investigated in a number of studies [516,517]. The surface treatment of biomaterials was also found to be important for cell adhesion [518].…”

Section: Tribology In Other Areasmentioning

confidence: 99%

A review of recent advances in tribology

et al. 2020

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The reach of tribology has expanded in diverse fields and tribology related research activities have seen immense growth during the last decade. This review takes stock of the recent advances in research pertaining to different aspects of tribology within the last 2 to 3 years. Different aspects of tribology that have been reviewed including lubrication, wear and surface engineering, biotribology, high temperature tribology, and computational tribology. This review attempts to highlight recent research and also presents future outlook pertaining to these aspects. It may however be noted that there are limitations of this review. One of the most important of these is that tribology being a highly multidisciplinary field, the research results are widely spread across various disciplines and there can be omissions because of this. Secondly, the topics dealt with in the field of tribology include only some of the salient topics (such as lubrication, wear, surface engineering, biotribology, high temperature tribology, and computational tribology) but there are many more aspects of tribology that have not been covered in this review. Despite these limitations it is hoped that such a review will bring the most recent salient research in focus and will be beneficial for the growing community of tribology researchers.

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Friction-limited cell motility in confluent monolayer tissue

Cited by 8 publications

References 50 publications

OncogenicRASinstructs morphological transformation of human epithelia via differential tissue mechanics

OncogenicRASinstructs morphological transformation of human epithelia via differential tissue mechanics

Physical Models of Collective Cell Migration

A review of recent advances in tribology

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