This work presents the application of a combined approach to investigate the friction losses in a modern four-cylinder passenger-car diesel engine. The approach connects the results from engine friction measurements using the indication method and the results from journal-bearing simulations. The utilization of the method enables a subassembly-resolved friction loss analysis that yields the losses of the piston group, crankshaft journal bearings, and valve train (including the timing drive and crankshaft seals). The engine and engine subassembly friction losses are investigated over the full speed and load range, covering more than 120 engine operation points at different engine media supply temperatures ranging from 70 to 110 ∘ C. The subsequently decreasing lubricant viscosity due to higher engine media supply temperatures allow for the identification of friction reduction potentials as well as possible risks due to an onset of mixed lubrication. Furthermore, additional strip-tests have been conducted to determine the friction losses of the crankshaft radial lip seals, the timing drive, and the crankshaft journal bearings, thus enabling a verification of the calculated journal-bearing friction losses with measurement results. For the investigated diesel engine, a friction reduction potential of up to 21% could be determined when increasing the engine media supply temperature from 70 to 110 ∘ C, at engine speeds higher than n = 1500 rpm and part load operating conditions. At low engine speeds and high load operations, the friction loss reduction potential is considerably decreased and below 8%, indicating mixed lubrication regimes at the piston group and valve train.