Friedländer bacillus meningitis successfully treated with streptomycin

Ayvazian, L. Fred

doi:10.1016/0002-9343(48)90095-3

Cited by 17 publications

(4 citation statements)

References 10 publications

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“…In general, the clinical features and the CSF findings of the infection are not very different from those of K. pneumoniae meningitis. Previous studies have shown that the incidence of diabetes mellitus is higher in patients with K. pneumoniae meningitis than in the general population [11,12] and diabetes mellitus is a poor prognostic factor in K. pneurnoniae,meningitis [2,13]. In our K. oxytoca meningitis cases, neither of these was found.…”

Section: Discussioncontrasting

confidence: 58%

Klebsiella oxytoca meningitis: Frequent association with neurosurgical procedures

Tang

Chen

1995

Infection

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Klebsiella oxytoca meningitis is a rare condition. Nine patients were diagnosed between 1981 and 1993 at our institution. These accounted for 2.3% of 393 patients with blood and/or cerebrospinal fluid culture-proven bacterial meningitis. K. oxytoca was noted in both community-acquired meningitis and nosocomial meningitis. Eight of the nine cases were patients who had undergone neurosurgical procedures. Four were mixed bacterial meningitis. All K. oxytoca isolates were susceptible to third-generation cephalosporins and all but one to chloramphenicol. Antibiotic therapy was successful in eight patients but failed in one.

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Section: Discussioncontrasting

confidence: 58%

Klebsiella oxytoca meningitis: Frequent association with neurosurgical procedures

Tang

Chen

1995

Infection

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“…In the present study, DM was more commonly seen as an underlying condition for patients with K. pneumoniae meningitis than for patients with nonklebsiella bacterial meningitis (27n7% vs. 7n3%, P 0n001). Previous studies have shown that the incidence of DM in patients with K. pneumoniae meningitis is higher than in the general population [28,29]. Also, diabetic patients were associated with an increased mortality (66n7% vs. 39n2%, P 0n05).…”

Section: Klebsiella Pneumoniae Meningitismentioning

confidence: 81%

Klebsiella meningitis in Taiwan: an overview

et al. 1997

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Klebsiella infection has been considered to be an uncommon cause of meningitis. To determine its incidence and clinical features, we reviewed the microbiologic records of cerebrospinal fluid (CSF) and blood cultures and the medical records of patients with bacterial meningitis admitted between 1981 and 1995. Klebsiella meningitis was diagnosed in 79 patients with 83 episodes. All patients had klebsiella isolated from CSF and/or blood and typical symptoms and signs of acute bacterial meningitis. Of these, 74 were over 16 years of age and 2 of the 5 children were infants. There was an increased prevalence rate of klebsiella meningitis after 1986. Of the 83 episodes, only 9 occurred between 1981 and 1986, accounting for 7.8% of 115 cases with CSF and/or blood culture-proven acute bacterial meningitis, whereas in 1987-95, there were 74 episodes accounting for 17.7% of 419 bacteriologically proven cases. K. pneumoniae accounted for 69 episodes, K. oxytoca, 11 episodes and K. ozaenae, 3 episodes. Male gender, diabetes mellitus and liver cirrhosis were commonly associated with K. pneumoniae meningitis. Neurosurgical procedures were frequently associated with K. oxytoca meningitis. All three patients with K. ozaenae meningitis had a primary disease of the nasopharyngeal pathway. The mortality rate due to K. pneumoniae was 48.5%, K. oxytoca, 10% and K. ozaenae, 0%. In patients with K. pneumoniae meningitis, poor prognostic factors included age over 60 years, diabetes mellitus, bacteremia and severe neurological deficits on the first day of treatment.

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“…Because the number of patients with K. ozaenae meningitis is too small, it is uncertain whether chloramphenicol should be replaced by third-generation cephalosporins in this particular infection. The incidence of diabetes mellitus in patients with K. pneumoniae meningitis is significantly higher than that in the general population [18,19]. A high mortality rate in patients with K. pneumoniae meningitis has been related to diabetes mellitus [20].…”

Section: Discussionmentioning

confidence: 99%

Klebsiella ozaenae meningitis: Report of two cases and review of the literature

Tang

Chen

1994

Infection

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Meningitis is rarely caused by Klebsiella ozaenae, a colonizer of the oral and nasopharyngeal mucosa. We describe two patients with K. ozaenae meningitis. Both patients suffered from a primary disease of the nasopharyngeal pathway; one had nasopharyngeal carcinoma and the other ozena. Review of the English-language literature from 1966 to the present revealed only two cases of K. ozaenae meningitis; pneumonia and hyperglycemia were noted in one patient and otitis media, sinusitis and diabetes mellitus in the other. All these four patients were over 50 years old. Of the four patients, two treated with third-generation cephalosporins recovered whereas one of the two treated with chloramphenicol died. One patient who died had a positive blood culture for K. ozaenae. Blood culture was positive in only one of the three survivors. Whether chloramphenicol should be replaced by a third-generation cephalosporin and whether blood culture indicates a poor prognosis in K. ozaenae meningitis remain to be determined.

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Friedländer bacillus meningitis successfully treated with streptomycin

Cited by 17 publications

References 10 publications

Klebsiella oxytoca meningitis: Frequent association with neurosurgical procedures

Klebsiella oxytoca meningitis: Frequent association with neurosurgical procedures

Klebsiella meningitis in Taiwan: an overview

Klebsiella ozaenae meningitis: Report of two cases and review of the literature

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