Friend or foe? Effect of oral resveratrol on cisplatin ototoxicity

Olgun, Yüksel; Kırkım, Günay; Kolatan, Efsun; Kıray, Müge; Bağrıyanık, Alper; Olgun, Aybüke; Kızmazoğlu, Deniz; Ellıdokuz, Hülya; Serbetcioglu, Bulent; Altun, Zekiye; Aktaş, Safiye; Yılmaz, Osman; Günerı, Enis Alpin

doi:10.1002/lary.24323

Cited by 32 publications

(31 citation statements)

References 23 publications

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“…In DPOAE evaluation, we used the frequency range of 1-8 kHz. Although we cannot relate the rat ototoxicity to the high-frequency ototoxic effects in human ototoxicity, the deterioration was particularly detected in 6 and 8 kHz in rats (Olgun et al 2014). …”

Section: Discussionmentioning

confidence: 82%

“…Some natural antioxidants, such as Vitamin E, Gingko Biloba, pomegranate and resveratrol (Yazici et al 2012;Olgun et al 2014), block the ototoxic effect of cisplatin. The otoprotective effect of resveratrol was observed only in low doses; otherwise, it enhanced the ototoxic impact of cisplatin in higher doses (Olgun et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…The otoprotective effect of resveratrol was observed only in low doses; otherwise, it enhanced the ototoxic impact of cisplatin in higher doses (Olgun et al 2014). However, there is no FDA-approved product for the treatment of cisplatin ototoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Pycnogenol V R inhibited apoptosis in various studies by suppressing ROS and caspase-3 activation (Siler-Marsiglio et al 2004). Cisplatin increases caspase-3 and ROS within the cochlea (Cho et al 2014;Olgun et al 2014). Pycnogenol V R may prevent the ototoxicity by suppressing ROS and caspase-3 activation.…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of Pycnogenol on cisplatin-induced ototoxicity in rats

Eryılmaz

Eliyatkın

Demirci

et al. 2016

Pharmaceutical Biology

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Context: PycnogenolV R , which is French maritime pine bark extract, is a potent antioxidant. It is used in medical conditions caused by oxidative stress. Cisplatin (cis-diamminedichloroplatinum II) is an antineoplastic agent. However, its serious side effects such as ototoxicity limit its usage. Objective: Antioxidants can be used to prevent ototoxicity. We investigated the effect of Pycnogenol V R on cisplatin-induced ototoxicity. Materials and methods: Rats were randomly assigned to four groups of five. Distortion product-evoked otoacoustic emissions (DPOAE) test was performed for each rat. The experimental groups were as follows: Control Group, Pycnogenol V R Group: 10 mg/kg Pycnogenol V R intraperitoneally for 7 days, Cisplatin Group: intraperitoneally 15 mg/kg single injection of cisplatin on the fifth day, Cisplatin þ Pycnogenol V R Group: intraperitoneally 10 mg/kg Pycnogenol V R treatment for 7 days, additionally on the fifth day, 15 mg/kg single injection of cisplatin was given. On the eighth day, DPOAE was re-performed and rats were sacrificed. Apoptosis was evaluated histopathologically. Results: Mean percentage of apoptotic cells was 1.5, 3, 30 and 11% in organ of Corti and 2, 2, 40, 15% in spiral ganglion neurons in Control Group, Pycnogenol V R Group, Cisplatin Group and Cisplatin þ Pycnogenol V R Group, respectively. Cisplatin Group and Cisplatin þ Pycnogenol V R Group were significantly different when compared to Control Group histopathologically both in organ of Corti and spiral ganglion neuron (p <0.001, p ¼ 0.019, p ¼ 0.001, p ¼ 0.015). DPOAE results showed that Cisplatin þ Pycnogenol V R Group was significantly different when compared to Cisplatin Group at 3, 6 and 8 kHz (p < 0.05). Conclusion: Pycnogenol protected against cisplatin ototoxicity. Also, pycnogenol is not ototoxic. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Protective effect of Pycnogenol on cisplatin-induced ototoxicity in rats

Eryılmaz

Eliyatkın

Demirci

et al. 2016

Pharmaceutical Biology

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“…Apoptosis-related gene expression analysis was done with the standard 84 array genes of Mouse apoptosis (SABiosciences; Valencia, USA) by real-time PCR as previously published [16] . …”

Section: Analysis Of Apoptosis-related Gene Expressionsmentioning

confidence: 99%

Protective Effect of Korean Red Ginseng on Cisplatin Ototoxicity: Is It Effective Enough?

Olgun¹,

Kırkım²,

Altun³

et al. 2016

Int Adv Otol

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1 (HEI-OC1) cell line. Cells were treated with CDDP, KRG, and their combination for 24 h. Cell viability, apoptosis, and the expression of 84 apoptosis-related genes were analyzed. In the second part of the study, 30 Wistar albino rats were divided into five groups. Baseline distortion product otoacoustic emissions (DPOAEs) and auditory brainstem response (ABR) measurements were obtained. In groups I, II, and III, only saline, KRG, and CDDP, respectively, were given. In group IV, 500 mg/kg KRG and in group V, 150 mg/kg of KRG were administered for 10 days. In groups III, IV, and V, 16 mg/kg CDDP injections were administered on day 11. On day 14, final DPOAEs and ABR measurements were completed. The rats were then sacrificed, and their inner ear structures were evaluated by transmission electron microscopy. RESULTS:In the first part of the study, pretreatment with 1 mg/mL KRG protected cells from CDDP ototoxicity. This protection was mainly due to a decline in apoptotic gene expression and an increase in antiapoptotic gene expression. In the in vivo part of the study, we found that both KRG doses had otoprotective effects. This protection was more prominent at the lower dose, especially on the spiral ganglion and the brainstem.CONCLUSION: KRG was shown to be an otoprotective agent against CDDP-induced ototoxicity both in vivo and in vitro.

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The effect of resveratrol on the histologic characteristics of the cochlea in diabetic rats

Erkan¹,

Tuhanioğlu²,

Gürgen

et al. 2018

The Laryngoscope

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Objectives/Hypothesis The aim of this study was to investigate changes in the cochlea and the potential dose‐dependent effects of resveratrol (RSV) against diabetes mellitus (DM) ototoxicity. Study Design Animal model. Methods Twenty‐four male Wistar albino rats were divided into four groups. Baseline distortion product otoacoustic emission (DPOAE) measurements were evaluated. Group I was the control group, group II was made diabetic with single‐dose streptozotocin, and groups III and IV were rendered diabetic as group II and administered 10 and 20 mg RSV, respectively, intraperitoneally for 4 weeks. All animals were sacrificed after repeated DPOAE measurement. Apoptosis was investigated using caspase‐3, Bax (Bcl‐associated X protein), and TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) staining. Results The DPOAE values in the diabetic group were found to be significantly lower compared with the other groups at 5,714 Hz and 8,000 Hz (P < .05). No significant difference in otoacoustic emission was detected in the comparison of the RSV doses (P > .05). The histopathologic investigation using caspase‐3, Bax, and TUNEL staining showed that the mean rank of the diabetic group was significantly higher compared with the RSV10, RSV20, and control groups (DM > RSV10 > RSV20 > control) (P < .05). Conclusions These results imply that RSV administration offered statistically significant protection for the cochleas of rats against diabetes. This protective effect improved histologically with higher doses. Level of Evidence NA Laryngoscope, 129:E1–E6, 2019

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Friend or foe? Effect of oral resveratrol on cisplatin ototoxicity

Abstract: Our results implied that there were noticeable differences between different oral RV doses used for cisplatin ototoxicity. Especially in higher doses, RV was observed to enhance cisplatin ototoxicity.

Cited by 32 publications

References 23 publications

Protective effect of Pycnogenol on cisplatin-induced ototoxicity in rats

Protective effect of Pycnogenol on cisplatin-induced ototoxicity in rats

Protective Effect of Korean Red Ginseng on Cisplatin Ototoxicity: Is It Effective Enough?

The effect of resveratrol on the histologic characteristics of the cochlea in diabetic rats

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