Friend or foe: Lactate in neurodegenerative diseases

Wang, Ming-Yu; Zhou, Yang; Li, Wen-Lian; Zhu, Ling-Qiang; Liu, Dan

doi:10.1016/j.arr.2024.102452

Ageing Research Reviews

2024

DOI: 10.1016/j.arr.2024.102452

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Friend or foe: Lactate in neurodegenerative diseases

Ming-Yu Wang,

Yang Zhou,

Wen-Lian Li

et al.

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2024

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Lactylation of tau in human Alzheimer's disease brains

Zhang,

Liu,

Rekowski

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONAggregation of hyperphosphorylated tau (tauopathy) is associated with cognitive impairment in patients with Alzheimer's disease (AD). In AD, a metabolic shift due to the Warburg effect results in increased lactate production. Lactate can induce a post‐translational modification (PTM) on proteins that conjugates lactyl groups to lysine (K) residues, which is known as lactylation.METHODSWe analyzed lactylation of tau in control and AD brain tissue and conducted cell‐based assays. In addition, we used in vitro assays to determine whether p300 catalyzed tau lactylation.RESULTSQuantitative proteomics detected that tau lactylation was elevated in AD brains, with K residue at position 331 (K331) being a prominent site. Lactate induced tau lactylation, which increased tau phosphorylation and cleavage and reduced ubiquitination. Inhibition of lactate production lowered tau lactylation; p300 catalyzed tau lactylation.DISCUSSIONOur findings suggest that tau lactylation links metabolic dysregulation with tauopathy and could serve as a novel diagnostic and therapeutic target.Highlights Elevated tau lactylation, particularly at K331, is evident in in human AD brain samples. Lactate induces tau lactylation, enhancing phosphorylation and cleavage while inhibiting ubiquitination. The acetyl‐transferase p300 catalyzes tau lactylation, with K331 being the most prominent site.

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Lactylation of tau in human Alzheimer's disease brains

Zhang,

Liu,

Rekowski

et al. 2024

Alzheimer's & Dementia

View full text Add to dashboard Cite

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Friend or foe: Lactate in neurodegenerative diseases

Cited by 1 publication

References 179 publications

Lactylation of tau in human Alzheimer's disease brains

Lactylation of tau in human Alzheimer's disease brains

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