1986
DOI: 10.1084/jem.164.1.211
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Friend virus-specific cytotoxic T lymphocytes recognize both gag and env gene-encoded specificities.

Abstract: We have constructed a series of "synthetic" target cell lines for an analysis of the specificity of anti-Friend virus (FV) CTL. Our results show that murine H-2 genes and individual retroviral genes can be stable expressed in Fisher rat embryo (FRE) cells, and that their products have the potential to form target structures recognized by mouse CTL. Cells expressing H-2Db and either the env or gag genes of one component of FV, helper Friend murine leukemia virus (FMuLV), were lysed by anti-FV CTL and by CTL gen… Show more

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Cited by 47 publications
(34 citation statements)
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“…systems, and a limited analysis of the intrahepatic (3)(4)(5) and PBL (6) response to HBV-encoded antigens, it appears that HBV-specific helper and CTL responses may play an important pathogenetic role in this disease. Since the viral nucleocapsid protein is an important target of the CTL response to other viruses (7)(8)(9)(10)(11), we have begun to examine the HLA class I-restricted CTL response to the hepatitis B nucleocapsid core antigen (HBcASg) in patients with acute and chronic viral hepatitis, type B.…”
Section: Discussionmentioning
confidence: 99%
“…systems, and a limited analysis of the intrahepatic (3)(4)(5) and PBL (6) response to HBV-encoded antigens, it appears that HBV-specific helper and CTL responses may play an important pathogenetic role in this disease. Since the viral nucleocapsid protein is an important target of the CTL response to other viruses (7)(8)(9)(10)(11), we have begun to examine the HLA class I-restricted CTL response to the hepatitis B nucleocapsid core antigen (HBcASg) in patients with acute and chronic viral hepatitis, type B.…”
Section: Discussionmentioning
confidence: 99%
“…Alterations of the viral genome that result in the abrogation of viral expression might permit tumor cells to elude immune surveillance, as already suggested in the case of other nondefective transforming retroviruses (12,14,20,38). Alternatively, these alterations might be required to generate LTR-derived structures which act as transcription activators and are responsible for growth stimulation or differentiation of the tumor cells.…”
Section: Discussionmentioning
confidence: 99%
“…Antigenic targets for the virus are less well defined although sites involved in complementmediated lysis, antibody-dependent cellular cytotoxicity of virus-infected cells (McCarty & Grant, 1983;Grant et al, 1980a) and neutralization (Osterhaus et al, 1989;deNoronha et al, 1983;Grant et al, 1980b) have been mapped to the gp70 and pI5E envelope proteins Nunberg et al, 1984;Nick et al, 1990). Studies with analogous viruses would also suggest that both the core gag and env protein can act as important immunological targets for cytotoxic T cells (Tc) (Holt et al, 1986;van der Hoorn et al, t985;Flyer et al, 1983;Manjunath et al, 1986;Martin & Rouse, 1990). This cytotoxicity would presumably be mediated through an endogenously processed antigen (Germain, 1986) which would arise most effectively through viral replication.…”
Section: Discussionmentioning
confidence: 99%
“…Whole virus vaccine preparations will obviously contain gag and there are reports of gag-specific antibody in FeLV-recovered animals (Lutz et al, 1980). The immune response(s) that this protein induces is not known although gag proteins from other retroviruses act as a target for Tc (Holt et al, 1986;van der Hoorn et al, 1985;Flyer et al, 1983, Manjunath et al, 1986. Its inclusion in any FeLV vaccine will thus broaden the immune response and if this is through the induction of Tc then it is possible that this response could be more effective against antigenically heterogeneous viruses because of the likelihood that the T cell response will be cross-reactive (Zweerink et al, 1977;Rosenthal & Zinkernagel, 1980;Jeggo & Wardley, 1982).…”
Section: Discussionmentioning
confidence: 99%