Frizzled7 as an emerging target for cancer therapy

King, Taj D.; Zhang, Wei; Suto, Mark J.; Li, Yonghe

doi:10.1016/j.cellsig.2011.12.009

Cited by 112 publications

(118 citation statements)

References 81 publications

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“…Recent reports indicate that the Fzd7 receptor undergoes overexpression in various tumors, including HCC. It plays a significant role in biology of stem cells, and in development and progression of malignant tumors [31].…”

Section: Receptors Of Frizzled Familymentioning

confidence: 99%

Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus

Rogacki¹,

Kasprzak²,

Stępiński³

2015

pjp

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Section: Receptors Of Frizzled Familymentioning

confidence: 99%

Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus

Rogacki¹,

Kasprzak²,

Stępiński³

2015

pjp

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“…Yes (116) No Breast cancer (82,117) ; prostate cancer (78) ; melanoma (93) ; colorectal cancer (118) ; gastric cancer (119) ; ovarian cancer (120) …”

Section: Fzd7mentioning

confidence: 99%

WNT5A and Its Receptors in the Bone-Cancer Dialogue

Thiele

Rachner

Rauner

et al. 2016

Journal of Bone and Mineral Research

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Wnt signaling is critical for tumorigenesis and skeletal remodeling. However, its contribution to the formation of metastatic bone lesions remains poorly defined. One major challenge of unraveling its role in cancer progression is the high complexity of Wnt signaling, which includes numerous ligands, receptors, and inhibitors, with intricate biological effects and specific signaling pathways depending on the cellular context. In this perspective, we summarize the role of the noncanonical Wnt ligand WNT5A in the development and metastatic process of osteotropic cancer entities. We focus on its tumor-suppressive function in breast cancer, tumor promoting effects in melanoma, and ambiguous role in prostate cancer, and discuss potential challenges and opportunities that may be associated with targeting Wnt signaling for cancer therapy and treatment of bone metastases.

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“…The highly conserved Wnt/FZD signaling pathway has multiple functions in animal development and cell fate determination and polarization [178]. Deregulation of the Wnt pathway and up-regulation of FZD receptors play important roles in tumorigenesis and CSC maintenance that is observed in a variety of human cancers, including colorectal cancer, hepatocellular carcinoma and triple-negative breast cancer [164,[178][179][180][181].…”

Section: Anti-frizzledmentioning

confidence: 99%

Targeting Human Cancer Stem Cells with Monoclonal Antibodies

Naujokat¹

2012

J Clin Cell Immunol

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Cancer stem cells (CSCs) constitute a distinct subpopulation of tumor cells that exhibit self-renewal and tumor initiation capacity and the ability to give rise to the heterogenous lineages of cancer cells that comprise the tumor. CSCs possess various intrinsic mechanisms of resistance to conventional chemotherapeutics, novel tumor-targeted drugs and radiation therapy, permitting them to survive current cancer therapies and to initiate tumor recurrence and metastasis. Different cell surface and transmembrane proteins expressed by CSCs, including CD44, CD47, EpCAM (CD326), CD123, CD133, GD2, Lgr5, insulin-like growth factor receptor I (IGF-IR), and members of the Notch and Wnt signaling pathways, have been identified and mainly used for the characterization of CSCs in experimental settings. Recently, monoclonal antibodies and antibody constructs such as Triomabs and BiTEs raised against these CSC proteins have shown efficacy against CSCs in human xenograft mice, and some of them have been demonstrated to induce tumor regression in clinical trials.Since current cancer therapies fail to eliminate CSCs, ultimately leading to cancer recurrence and progression, selective targeting of CSCs with mAbs and antibody constructs reviewed herein may represent a novel and promising therapeutic strategy to eradicate cancer.

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Frizzled7 as an emerging target for cancer therapy

Cited by 112 publications

References 81 publications

Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus

Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus

WNT5A and Its Receptors in the Bone-Cancer Dialogue

Targeting Human Cancer Stem Cells with Monoclonal Antibodies

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